Association between arginine catabolism and major depressive disorder

Cao, Bing; Deng, Runze; Wang, Dongfang; Li, Li; Ren, Zhijun; Gao, Xiao

doi:10.1097/md.0000000000021068

Cited by 9 publications

(1 citation statement)

References 27 publications

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“…Metabolic pathways of arginine biosynthesis and arginine and proline metabolism occurred to be important in the PFC of rats exposed to US stress. Arginine, which is a semi-essential amino acid, is the substrate of major physiological processes in CNS, such as the urea cycle and nitric oxide cycle, so any imbalance of arginine can lead to metabolic disorders [58,59]. As has been shown in a large number of studies, there is a connection between imbalance of arginine blood concentration and accumulation of corresponding catabolic substances, NO regulation abnormalities, and the pathophysiology of major depressive disorder [60,61].…”

Section: Discussionmentioning

confidence: 99%

Brain Metabolic Profile after Intranasal vs. Intraperitoneal Clomipramine Treatment in Rats with Ultrasound Model of Depression

Abramova

Zorkina

Syunyakov

et al. 2021

IJMS

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Background: Molecular mechanisms of depression remain unclear. The brain metabolome after antidepressant therapy is poorly understood and had not been performed for different routes of drug administration before the present study. Rats were exposed to chronic ultrasound stress and treated with intranasal and intraperitoneal clomipramine. We then analyzed 28 metabolites in the frontal cortex and hippocampus. Methods: Rats’ behavior was identified in such tests: social interaction, sucrose preference, forced swim, and Morris water maze. Metabolic analysis was performed with liquid chromatography. Results: After ultrasound stress pronounced depressive-like behavior, clomipramine had an equally antidepressant effect after intranasal and intraperitoneal administration on behavior. Ultrasound stress contributed to changes of the metabolomic pathways associated with pathophysiology of depression. Clomipramine affected global metabolome in frontal cortex and hippocampus in a different way that depended on the route of administration. Intranasal route was associated with more significant changes of metabolites composition in the frontal cortex compared to the control and ultrasound groups while the intraperitoneal route corresponded with more profound changes in hippocampal metabolome compared to other groups. Since far metabolic processes in the brain can change in many ways depending on different routes of administration, the antidepressant therapy should also be evaluated from this point of view.

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