Association between arterial hypertension and chronic obstructive pulmonary disease: role of AGT gene polymorphism

Maksiv, Khrystyna; Krynytska, Іnna; Kozak, Kateryna

doi:10.2478/pneum-2019-0036

Cited by 2 publications

(1 citation statement)

References 47 publications

(46 reference statements)

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“…et al, 2019 ). In another study, the presence of Т allele of the AGT gene with increase the risk of AH in patients suffer from COPD ( Marushchak et al, 2019b ).…”

Section: Discussionmentioning

confidence: 99%

Genetic and epigenetic factors of arterial hypertension: a bibliometric- and in-silico-based analyses

Karabaeva,

Vochshenkova,

Zare

et al. 2023

Front. Mol. Biosci.

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Introduction: Arterial hypertension (AH) is a pervasive global health concern with multifaceted origins encompassing both genetic and environmental components. Previous research has firmly established the association between AH and diverse genetic factors. Consequently, scientists have conducted extensive genetic investigations in recent years to unravel the intricate pathophysiology of AH.Methods: In this study, we conducted a comprehensive bibliometric analysis employing VOSviewer software to identify the most noteworthy genetic factors that have been the focal point of numerous investigations within the AH field in recent years. Our analysis revealed genes and microRNAs intricately linked to AH, underscoring their pivotal roles in this condition. Additionally, we performed molecular docking analyses to ascertain microRNAs with the highest binding affinity to these identified genes. Furthermore, we constructed a network to elucidate the in-silico-based functional interactions between the identified microRNAs and genes, shedding light on their potential roles in AH pathogenesis.Results: Notably, this pioneering in silico examination of genetic factors associated with AH promises novel insights into our understanding of this complex condition. Our findings prominently highlight miR-7110-5p, miR-7110-3p, miR-663, miR-328-3p, and miR-140-5p as microRNAs exhibiting a remarkable affinity for target genes. These microRNAs hold promise as valuable diagnostic and therapeutic factors, offering new avenues for the diagnosis and treatment of AH in the foreseeable future.Conclusion: In summary, this research underscores the critical importance of genetic factors in AH and, through in silico analyses, identifies specific microRNAs with significant potential for further investigation and clinical applications in AH management.

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“…et al, 2019 ). In another study, the presence of Т allele of the AGT gene with increase the risk of AH in patients suffer from COPD ( Marushchak et al, 2019b ).…”

Section: Discussionmentioning

confidence: 99%

Genetic and epigenetic factors of arterial hypertension: a bibliometric- and in-silico-based analyses

Karabaeva,

Vochshenkova,

Zare

et al. 2023

Front. Mol. Biosci.

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Quantitative Morphological Aspects of the Study of the Features of the Remodeling of the Hemomicrocirculatory Channel of the Testicles Under the Action of Aluminum Chloride on the Body

Konovalenko,

Kritsak,

Yasinovskyi

et al. 2023

Wiad Lek

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The aim: To conduct a morphometric analysis of the features of the remodeling of vessels of the hemomicrocirculatory channel of the testicles under the action of aluminum chloride on the body. Materials and methods: The testicles of 52 white male Wistar rats were morphologically studied, which were divided into two groups: intact and animals injected with aluminum chloride at a dose of 100 mg/kg. Results: The long-term effect of aluminum chloride on the body led to pronounced changes in the quantitative morphological indicators of the vessels of the hemomicrocirculatory channel of the testes compared to the control ones. The diameter of arterioles of the left testicle decreased by 18.4%, precapillary arterioles by 19.1%, hemocapillaries by 10.1%. The diameter of the postcapillary venules of the left testicle increased by 26.3%, the venules by 26.4%, and the density of microvessels decreased by 30.0%, which indicated the deterioration of its blood supply. The degree of remodeling of microvessels in the right testis was less pronounced. The diameter of arterioles of the right testicle decreased by 17.1%, precapillary arterioles by 18.4 %, and hemocapillaris by 9.1%. The diameter of the postcapillary venules of the right testicle increased by 25.5%, the venules by 27.0%, and the density of microvessels decreased by 25.8%. Conclusions: Long-term action (during the month) of aluminum chloride on the body leads to pronounced remodeling of the vessels of the hemomicrocirculatory channel of the testicles, which is characterized by a pronounced narrowing of its supply (arterioles, precapillary arterioles), exchange (hemocapillaries) links.

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Association between arterial hypertension and chronic obstructive pulmonary disease: role of AGT gene polymorphism

Cited by 2 publications

References 47 publications

Genetic and epigenetic factors of arterial hypertension: a bibliometric- and in-silico-based analyses

Genetic and epigenetic factors of arterial hypertension: a bibliometric- and in-silico-based analyses

Quantitative Morphological Aspects of the Study of the Features of the Remodeling of the Hemomicrocirculatory Channel of the Testicles Under the Action of Aluminum Chloride on the Body

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