Association between aspirin use and the prevalence of nonalcoholic fatty liver disease: a cross-sectional study from the Third National Health and Nutrition Examination Survey

Shen, Huafeng; Shahzad, Ghulamullah; Jawairia, Mahreema; Bostick, Roberd M.; Mustacchia, Paul

doi:10.1111/apt.12944

Cited by 51 publications

(29 citation statements)

References 30 publications

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“…This definition is in accordance with our previous study and previous publications on NAFLD using NHANES dataset 16-18 . Controls were defined as participants with normal liver enzymes and no evidence of chronic liver disease.…”

Section: Methodssupporting

confidence: 89%

“…The pathogenesis of NAFLD and the progression to NASH are complex, involving a combination of lipid oxidation, oxidative stress, inflammatory cells as well as proinflammatory cytokines 1, 16 . Alterations in lipid metabolism drive the polarization of the Kupffer cells into the proinflammatory phenotype; which trigger the recruitment of inflammatory cells and the progression of underlying NAFLD 2 .…”

Section: Discussionmentioning

confidence: 99%

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Histamine H2-Receptor Antagonist Use Is Associated With Lower Prevalence of Nonalcoholic Fatty Liver Disease

Shen

Liangpunsakul

2016

Journal of Clinical Gastroenterology

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Background & Aim Recent basic mechanistic studies found that proton pump inhibitors (PPIs) or histamine antagonists inhibited multiple pathways involved in non-alcoholic fatty liver disease (NAFLD) development. The aim of this study was to investigate an association between PPIs or H1/H2-receptor antagonists (H1RAs/H2RAs) use and NAFLD prevalence in the general US population. Methods We conducted a cross-sectional analysis of data from the National Health and Nutrition Examination Survey, 2001 – 2006. We included 10,398 adults aged 20 – 74 years who had alanine aminotransferase (ALT) data; of those, 2,058 were identified as having NAFLD and 8,340 as controls. PPIs or H1RAs/H2RAs use was defined as use of prescription medications in the preceding month. The length of use was categorized as ≤ 60 days and > 60 days. NAFLD was defined as elevated serum aminotransferases without any indication of other causes of chronic liver disease. Results In the multivariate unconditional logistic regression analysis, H2RAs use was inversely associated with prevalent NAFLD (odds ratio [OR] = 0.43, 95% confidence interval [CI] 0.18 – 0.99), a finding that was primarily limited to men (OR = 0.18, 95% CI 0.04 – 0.79) and those with insulin resistance (OR = 0.22, 95% CI 0.05 – 0.95). However, no significant associations were found between PPIs or H1RAs use and prevalent NAFLD. Conclusion These findings, from the first human study to investigate an association of PPIs or H1RAs/H2RAs use with NAFLD, suggest that H2RAs use may be associated with a lower prevalence of NAFLD, primarily among men with insulin resistance.

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Section: Methodssupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Histamine H2-Receptor Antagonist Use Is Associated With Lower Prevalence of Nonalcoholic Fatty Liver Disease

Shen

Liangpunsakul

2016

Journal of Clinical Gastroenterology

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“…These studies, however, need to be interpreted with caution as the antiplatelet drug cilostizol, demonstrated to have the most marked effect on reducing hepatic steatosis, inflammation, and fibrosis in mice on high‐fat/high‐calorie or choline‐deficient diets, has numerous “nonplatelet” effects. Data regarding antiplatelet therapy and liver disease in humans are generally lacking, but a large recent cross‐sectional analysis suggests that regular aspirin use may be associated with a lower prevalence of NAFLD …”

Section: Disease‐specific Platelet Contributionmentioning

confidence: 99%

Platelets: No longer bystanders in liver disease

et al. 2016

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Growing lines of evidence recognize that platelets play a central role in liver homeostasis and pathobiology. Platelets have important roles at every stage during the continuum of liver injury and healing. These cells contribute to the initiation of liver inflammation by promoting leukocyte recruitment through sinusoidal endothelium. They can activate effector cells, thus amplifying liver damage, and by modifying the hepatic cellular and cytokine milieu drive both hepatoprotective and hepatotoxic processes. Conclusion: In this review we summarize how platelets drive such pleiotropic actions and attempt to reconcile the paradox of platelets being both deleterious and beneficial to liver function; with increasingly novel methods of manipulating platelet function at our disposal, we highlight avenues for future therapeutic intervention in liver disease. (Hepatology 2016;64:1774‐1784)

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“…Aspirin was discovered in 18th century as a treatment for fever, pain, rheumatic fever, and inflammatory diseases. Today, the anti-platelet properties of aspirin have made it a drug of choice for prevention of cardiovascular and cerebrovascular catastrophes, such as stroke and myocardial infarction [4,5]. Human studies suggest aspirin may also affect oxidative stress, vascular inflammation, and insulin sensitivity [6,7].…”

Section: Introductionmentioning

confidence: 99%

Fisher Discrimination of Metabolic Changes in Rats Treated with Aspirin and Ibuprofen

Zhang

Song²,

Jiang³

et al. 2017

Pharmacology

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Background: Aspirin and ibuprofen are the most frequently prescribed non-steroidal anti-inflammatory drugs in the world. However, both are associated with a variety of toxicities. We applied serum metabonomics and Fisher discrimination for the early diagnosis of its toxic reaction in order to help diagnose these toxicities. Methods: A total of 45 rats were randomly divided into Control group, Aspirin group, and Ibuprofen groups. The experiment groups were given intragastric aspirin (15 mg/kg) or ibuprofen (15 mg/kg) for 3 weeks. Liver function tests were performed and blood metabonomics were analyzed by gas chromatography-mass spectrometry. Results: The most important compounds altered were trihydroxybutyric acid and l-alanine in the aspirin group, and acetoacetic acid, l-alanine, and trihydroxybutyric acid in the ibuprofen group. With respect to metabolic profiles, all 3 groups were completely distinct from one another. Fisher discrimination showed that 91.1% of the original grouped cases were correctly classified by the third week. However, only 55.6% of liver function tests were able to classify grouped cases correctly. Conclusion: Trihydroxybutyric acid, l-alanine, and acetoacetic acid were the most significant indicators of altered serum metabolites following intragastric administration of aspirin and ibuprofen in rates. These metabolomic data may be used for classification of aspirin and ibuprofen toxicity.

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Association between aspirin use and the prevalence of nonalcoholic fatty liver disease: a cross-sectional study from the Third National Health and Nutrition Examination Survey

Abstract: SUMMARY BackgroundMany basic mechanistic studies found that aspirin inhibited multiple pathways involved in non-alcoholic fatty liver disease (NAFLD) development.

Cited by 51 publications

References 30 publications

Histamine H2-Receptor Antagonist Use Is Associated With Lower Prevalence of Nonalcoholic Fatty Liver Disease

Histamine H2-Receptor Antagonist Use Is Associated With Lower Prevalence of Nonalcoholic Fatty Liver Disease

Platelets: No longer bystanders in liver disease

Fisher Discrimination of Metabolic Changes in Rats Treated with Aspirin and Ibuprofen

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