Association between asthenia and nutritional status, lean body mass, anemia, psychological status, and tumor mass in patients with advanced breast cancer

Bruera, Éduardo; Brenneis, Carleen; Michaud, M.; Rafter, Jennifer; Magnan, A.; Tennant, Angela; Hanson, John; MacDonald, Raymond

doi:10.1016/0885-3924(89)90023-7

Cited by 64 publications

(48 citation statements)

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“…Step 1 other studies which have found a positive relationship between these two constructs in patients with cancer (Bruera et al, 1989;Morant et al, 1993;Smets et al, 1996). The discrepancy may partly be explained by the nature of our patient sample.…”

Section: Patients Controlsmentioning

confidence: 52%

“…Bruera and coworkers (Bruera et al, 1989) failed to find any such association in patients with advanced breast cancer, but concluded that this was probably due to their studying a relatively well nourished group of patients. In our study, despite a high prevalence of cachexia we were still unable to find an association between fatigue and nutritional status.…”

Section: Discussionmentioning

confidence: 95%

“…However no study has yet demonstrated that these changes in muscle function are associated with increases in subjective fatigue. In the general population fatigue is frequently associated with psychological morbidity (Pawlikowska et al, 1994;Lawrie and Pelosi, 1995) and a similar association has been found in cancer patients receiving chemotherapy or radiotherapy (Bruera et al, 1989;Blesch et al, 1991;Morant, 1996;Smets et al, 1996). Other putative causes of cancer-related-fatigue include anaemia, biochemical abnormalities, the severity of other symptoms and non-specific 'stress'.…”

mentioning

confidence: 97%

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Fatigue in advanced cancer: a prospective controlled cross-sectional study

et al. 1999

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Summary Uncontrolled studies have reported that fatigue is a common symptom among patients with advanced cancer. It is also a frequent complaint among the general population. Simply asking cancer patients whether or not they feel fatigued does not distinguish between the 'background' level of this symptom in the community and any 'excess' arising as a result of illness. The aim of this study was to determine the prevalence of fatigue among palliative care inpatients in comparison with a control group of age and sex-matched volunteers without cancer. In addition, the correlates of fatigue were investigated. The prevalence of 'severe subjective fatigue' (defined as fatigue greater than that experienced by 95% of the control group) was found to be 75%. Patients were malnourished, had diminished muscle function and were suffering from a number of physical and mental symptoms. The severity of fatigue was unrelated to age, sex, diagnosis, presence or site of metastases, anaemia, dose of opioid or steroid, any of the haematological or biochemical indices (except urea), nutritional status, voluntary muscle function, or mood. A multivariate analysis found that fatigue severity was significantly associated with pain and dypnoea scores in the patients, and with the symptoms of anxiety and depression in the controls. The authors conclude that subjective fatigue is both prevalent and severe among patients with advanced cancer. The causes of this symptom remain obscure. Further work is required in order to determine if the associations reported between fatigue and pain and between fatigue and dyspnoea are causal or coincidental.Keywords: fatigue; asthenia; neoplasms; palliative care; quality of life 1479British Journal of Cancer (1999) 79(9/10), 1479-1486 © 1999 Cancer Research Campaign Article no. bjoc.1998 Received SUBJECTS AND METHODSInpatients with advanced cancer were recruited from three palliative care units between April 1996 and January 1997. Radiotherapy or chemotherapy within the previous 4 weeks, clinically apparent confusion, poor English language skills, disability or pain affecting the non-dominant hand or an estimated prognosis of less than 2 weeks were all exclusion criteria. The principal investigator visited each of the participating units weekly and approached all patients identified as being eligible to enter the study. In the absence of the principal investigator, due to holidays or illness, recruitment was suspended. Thus, although the patient group did not represent a consecutive series of eligible patients (i.e. it was a convenience sample), there is no reason to suspect a systematic bias in patient selection. Control subjects were age and sex-matched volunteers without cancer. They were recruited from the 'League of Friends' at the respective units and were subjected to the same inclusion and exclusion criteria as the patients. The protocol was approved by the relevant Scientific and Ethics Committees.After informed consent had been obtained, the patients were asked to undergo a number of assessme...

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Section: Patients Controlsmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 95%

mentioning

confidence: 97%

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Fatigue in advanced cancer: a prospective controlled cross-sectional study

et al. 1999

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“…Some study refuting the association between anemia & fatigue [17][18][19] and some stating that there is a positive association [10] .…”

Section: Anemia and Cancer Relate Fatigue-is The Association Significmentioning

confidence: 99%

Cancer related fatigue-Analysing its causes to find the road map to its treatment- in the Indian scenario

.C¹

2017

JMSCR

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“…305 Poorly controlled pain or inadequately assessed fatigue contribute to psychological distress and impairment of physical and social functioning. 158,[306][307][308][309] Patients with metastatic disease have a significantly greater unmet need for assistance with physical aspects of daily living compared with the needs of patients in remission. 310 …”

Section: Physical Issues Towards the End Of Lifementioning

confidence: 99%

Broken doctor–patient relationships: why won't they listen?

Jefford

Zalcberg

2014

Medical Journal of Australia

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Every user of this rescinded publication acknowledges that the information contained in it may not be accurate, complete or of relevance to the user's purposes. The user undertakes the responsibility for assessing the accuracy, completeness and relevance of the contents of this rescinded publication, including seeking independent verification of information sought to be relied upon for the user's purposes.Every user of this rescinded publication is responsible for ensuring that each printed version contains this disclaimer notice, including the date of recision and the date of downloading the archived Internet version. This work is copyright.Apart from any use as permitted under the Copyright Act 1968, no part may be reproduced by any process without prior written permission from National Breast Cancer Centre. Requests and enquiries concerning reproduction and rights should be addressed to the Copyright Office, National Breast Cancer Centre, Locked Bag 16, Camperdown NSW 1450, Australia.Website:www.nbcc.org.au Email: directorate@nbcc.org.au These guidelines were approved by the National Health and Medical Research Council at its 147th Session on 10 April 2003, under section 14A of the National Health and Medical Research Council Act 1992.Approval for the guidelines by NHMRC is granted for a period not exceeding five years, at which date the approval expires.The NHMRC expects that all guidelines will be reviewed no less than once every five years. Readers should check with the National Breast Cancer Centre for any reviews or updates of these guidelines. RESCINDEDThe strategic intent of the NHMRC is to provide leadership and work with other relevant organisations to improve the health of all Australians by:• fostering and supporting a high quality and internationally recognised research base; • providing evidence based advice; • applying research evidence to health issues thus translating research into better health practice and outcomes; and • promoting informed debate on health and medical research, health ethics and related issues.This document is a general guide to appropriate practice, to be followed subject to the clinician's judgement and the patient's preference in each individual case.The guidelines are designed to provide information to assist decision-making and are based on the best evidence available at the time of publication. C O N T E N T S L I S T O F TA B L E S L I S T O F F I G U R E S F O R E W O R DOptimal care of the patient with cancer incorporates effective physical and psychological care.There are currently several clinical practice guidelines available documenting evidence-based information and treatment recommendations for the physical care of people with cancer, many of which are also available in consumer versions. Some of these treatment guidelines include chapters devoted to psychosocial care.People with cancer suffer significant emotional morbidity. In addition to the distress, fear and grief consequent upon diagnosis, up to 30% experience clinically significant anxiety disorde...

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Association between asthenia and nutritional status, lean body mass, anemia, psychological status, and tumor mass in patients with advanced breast cancer

Cited by 64 publications

References 15 publications

Fatigue in advanced cancer: a prospective controlled cross-sectional study

Fatigue in advanced cancer: a prospective controlled cross-sectional study

Cancer related fatigue-Analysing its causes to find the road map to its treatment- in the Indian scenario

Broken doctor–patient relationships: why won't they listen?

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