Association between asthma and dysphonia: A population-based study

Park, Bumjung; Choi, Hyo Geun

doi:10.3109/02770903.2016.1140181

Cited by 11 publications

(7 citation statements)

References 19 publications

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“…Laryngeal mucosal inflammation was reported in only three asthmatic patients, and no laryngeal candidiasis was found. Our results were close to those found by Park et al, 13 who performed a large cross-sectional study comparing subjective voice complaints and organic laryngeal diseases (vocal cord polyps, vocal cord nodules, or laryngitis).…”

Section: Discussionsupporting

confidence: 92%

“…10,12 Dysphonia has been described as more frequent in asthma than healthy subjects (11.3% vs. 5.5%). 13 An uncontrolled study on asthma has estimated an association with dysphonia in 50% of cases. 14 The main hypothesis, supported by only two limited uncontrolled studies, 15,16 was that dysphonia was caused by inhaled corticosteroids by favoring candidiasis or inducing myopathic bowing of the vocal cords.…”

Section: Introductionmentioning

confidence: 99%

“…Dysphonia has been described as more frequent in asthma than healthy subjects (11.3% vs. 5.5%) 13 . An uncontrolled study on asthma has estimated an association with dysphonia in 50% of cases 14 .…”

Section: Introductionmentioning

confidence: 99%

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Laryngeal dysfunction is prominent in asthmatic women treated by inhaled corticosteroids

Migueres

Delmas²,

Thomas

et al. 2022

Clinical & Translational All

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Background Dysphonia is a frequent comorbidity of asthma and has been suggested to be a local side effect of inhaled corticosteroids due to laryngeal candidiasis. We hypothesized that dysphonia in asthmatics was not due to laryngeal organic lesions but to laryngeal dysfunction during phonation (LDP). Objective We compared the frequency of LDP in female asthmatic patients treated with inhaled corticosteroids to female controls. Methods We compared 68 asthmatic female patients to 53 female control subjects. Pulmonary function tests were performed and the asthmatic patients classified according to the level of inhaled corticosteroids. Dysphonia was defined as a Vocal Handicap Index ≥18 or GRBAS score ≥2. All patients underwent video laryngo‐strobe examination, analyzed blindly and separately by two otolaryngologists, describing mucosal changes, LDP, or Organic lesions linked to Laryngeal Dysfunction during Phonation (OLDP). Results 66.2% of the asthmatic patients exhibited dysphonia and 11.3% of controls ( p < 0.001). No laryngeal candidiasis was found, only 3 patients presented laryngeal mucosa inflammation. LDP was observed in 60.3% of asthmatic patients and 18.9% of controls ( p < 0.001), and no difference was found for OLDP (11.8% vs. 13.2%). No association was made between LDP, the dosage of inhaled corticosteroid, and bronchial obstruction. Conclusions Asthmatic patients were more dysphonic than control subjects. This phenomenon was not explained by mucosal inflammation, laryngeal candidiasis or OLDP. Asthmatic patients had more LDP than controls. There was no relation between LDP, inhaled corticosteroids dosage or bronchial obstruction. These results change our view of inhaled corticosteroid side effects in female asthmatic patients.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Laryngeal dysfunction is prominent in asthmatic women treated by inhaled corticosteroids

Migueres

Delmas²,

Thomas

et al. 2022

Clinical & Translational All

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“…Our study showed that children with asthma had higher scores on pVHI compared to healthy children, indicating a greater likelihood of the development of voice complaints. These results are similar to the findings of two studies with adult studies where the participants with asthma scored significantly higher on voice quality parameters than the control group [16,17]. In addition, patients with allergy have also been reported to have a higher degree of vocal dysfunction measured with VHI than patients without allergy [18].…”

Section: Discussionsupporting

confidence: 88%

“…In addition, we showed that pVHI scores were correlated positively with AR severity [19]. Previous studies with adult participants have shown that dysphonia was significantly more prevalent in patients with asthma compared to healthy participitans [5,16,17]. Restricted expiration, decreased lung volume, diaphragm, together with fluctuations in intra-thoracic and intra-abdominal pressures might hypothetically explain the significantly higher prevalence of voice disorders in patients with asthma.…”

Section: Discussionmentioning

confidence: 51%

Evaluation of Turkish pediatric voice handicap index in children with asthma

Filiz¹

2020

Ann Clin Anal Med

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Aim: The purpose of the study was to evaluate the voice quality in children with asthma by subjective methods. Material and Method: Children with mildto-severe asthma (n=91) and age-sex matched healthy controls (n=79) without present or past history of voice disorders were included in the study. The Turkish version of the Pediatric Voice Handicap Index (pVHI) was used to access the impact on functional, physical, and emotional aspects of voice and oral communication. Results: A significant difference was noted between patients with asthma and controls with regard to pVHI scores. Indicating a greater chance of voice disorders was observed in patients with asthma (P<0.005). The scores of three domains and the total score of pVHI were prevalent in children with asthma. In addition, as the severity of asthma increased, high scores of pVHI were observed (p:0.01). Discussion: Our study showed that children with asthma had higher scores on pVHI compared to healthy children, indicating a greater likelihood of the development of voice complaints. A positive correlation was found between the severity of asthma and pVHI scores Keywords Pediatric; Voice Handicap Index; Asthma | The Annals of Clinical and Analytical Medicine Voice handicap index in asthma

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Cannabis Inhalation and Voice Disorders

Meehan-Atrash

Korzun

Ziegler

2019

JAMA Otolaryngol Head Neck Surg

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Widespread legalization of cannabis throughout the United States has created a knowledge gap that leaves practitioners who manage voice disorders uninformed about this substance, commonly referred to as marijuana. The association of cannabis inhalation and voice disorders is rarely reported. However, studies on the association between cannabis inhalation and respiration have been published; therefore, these studies may serve as a surrogate for studies on the association between cannabis and phonation.OBJECTIVE To review the literature on the association of cannabis-only consumption via smoking and vaping with the health and function of the vocal mechanism to aid clinical recommendations for patients with voice disorders.EVIDENCE REVIEW This systematic review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement. An electronic search in MEDLINE via PubMed, CINAHL, Scopus, and Cochrane Library databases for original research on inhaled cannabis was performed from January 1, 2007, through August 10, 2018. The search strategy included Medical Subject Heading terms and keywords marijuana, cannabis, respiratory, lungs, larynx, voice, phonation, and vocal with Boolean operators (AND, OR). Studies of participants of legal age (Ն18 years) who had cannabis-only clinical data and used nonsynthetic cannabinoids were included in the review. FINDINGS This systematic review identified 6 clinical science studies and 13 basic science or animal studies. The only study to date that has evaluated the association between laryngeal symptoms and inhaling cannabis found that human smokers assessed by indirect laryngoscopy with mirror examination exhibited dark vocal folds. Analyses of 6 other clinical science articles indicated an association between cannabis inhalation and respiratory problems that were reduced with smoking cessation or switching to vaporizing. Lung function was maintained in light cannabis smoke exposure after long-term use. Analyses of basic science and animal articles indicated that cannabis smoking was associated with lung and throat injuries attributable to smoking degradation by-products, similar to injuries seen in human tobacco smoking. CONCLUSIONS AND RELEVANCEThe findings suggest that cannabis-only smoking is associated with changes in vocal fold appearance, respiratory symptoms, and negative lung function changes, especially in heavy smokers. Details about patterns of cannabis consumption appear to be relevant to gather in patients with voice disorders. Results further suggest that cannabis smokers presenting with a voice disorder should undergo laryngeal imaging and complete pulmonary function testing when indicated and receive education about consumption methods and their association with voice disorders.

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Association between asthma and dysphonia: A population-based study

Abstract: Asthma patients are predisposed to subjective dysphonia due to demographic and clinical characteristics (older age, female, and higher stress level) as well as to asthma itself. However, asthma was not associated with organic laryngeal lesions in this study.

Cited by 11 publications

References 19 publications

Laryngeal dysfunction is prominent in asthmatic women treated by inhaled corticosteroids

Laryngeal dysfunction is prominent in asthmatic women treated by inhaled corticosteroids

Evaluation of Turkish pediatric voice handicap index in children with asthma

Cannabis Inhalation and Voice Disorders

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