Association between AT C573T polymorphism and cardiovascular risk factors in myocardial infarction

Morales-Suárez-Varela, María; Riera-Fortuny, Concepción; Mansego, María L.; Martínez-Triguero, María L.; Chaves, Felipe Javier; Martín-Moreno, José M.; Bañuls, Celia; Hernández‐Mijares, Antonio

doi:10.1016/j.carpath.2010.04.002

Cited by 4 publications

(4 citation statements)

References 24 publications

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“…Canavy et al 21 reported the prevalence of the C allele carriers being higher in patients with MI than in control individuals. However, some other studies reported that AT1R A1166C gene polymorphism was not associated with the MI risk 19,[22][23][24][25]27 AT1R A1166C gene polymorphism might be not associated with MI susceptibility in Caucasians. However, more studies in Caucasians should be performed in the future.…”

Section: Discussionmentioning

confidence: 89%

“…In this study, we also performed a meta-analysis to investigate the association of AT1R A1166C gene polymorphism with acute MI/old MI susceptibility. Ten repo rts 19,23,24,26,29,30,[32][33][34][35] were included for acute MI, and two reports 25,27 The frequency of the C allele in some studies 29,31,32,35 was very low compared to that in other included studies, and those studies were excluded from our further metaanalysis. The frequency of C allele in the case group of the study from Mehri et al 34 was much higher than that in the control group (41.1% vs 29.33%), and this study was also excluded from our further meta-analysis.…”

Section: Discussionmentioning

confidence: 99%

“…The data of interest were extracted: first author's surname, year of publication and the number of cases and controls for AT1R A1166C genotypes (Table 1). Those 18 investigations [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] contained 6794 cases and 6204 controls, including 11 studies of Caucasians, [18][19][20][21][22][23][24][25][26][27][28] three studies of Asians, 29,30,35 two studies of Africans, 31,34 one study in the population of Durban in South Africa, 32 and one study in the Brazilian population. 33 The average frequency of C allele distribution in patients with MI for overall populations was 24.74% and the average frequency in controls was 22.58%.…”

Section: Study Characteristics For MImentioning

confidence: 99%

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A systematic review and meta-analysis of the association between angiotensin II type 1 receptor A1166C gene polymorphism and myocardial infarction susceptibility

Zheng

Shi

et al. 2012

J Renin Angiotensin Aldosterone Syst

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Background and aim: Many reported studies have been conducted to investigate the association of angiotensin II type 1 receptor (AT1R) A1166C gene polymorphism with myocardial infarction (MI) susceptibility. However, the results from those reports are still conflicting. This meta-analysis was performed to study the relationship between AT1R A1166C gene polymorphism and MI risk. Method: The databases of PubMed, Embase, and Cochrane Library were searched as of 1 March 2012, and eligible investigations were recruited into this meta-analysis. Results: Eighteen investigations were identified for the analysis of association between AT1R A1166C gene polymorphism and MI risk, 11 in Caucasians, three in Asians, two in Africans, one in the population of Brazil and one in the population of Durban, South Africa . There was a marked association between AT1R C allele and MI susceptibility for overall populations (odds ratio (OR)=1.12, 95% confidence interval (CI): 1.01-1.25, p=0.03), and AT1R AA genotype was associated with a lower risk of MI in overall populations (OR=0.87, 95% CI: 0.78-0.98, p=0.02). However, AT1R A1166C gene polymorphism was not associated with MI risk in the sub-groups of Caucasians, Asians, Africans, Brazil and Durban populations. Conclusions: C allele is a risk factor for the MI susceptibility in overall populations, and AA genotype might be a protective factor against the MI risk in overall populations. However, more case-control association investigations on larger, stratified populations are required in the future.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Study Characteristics For MImentioning

confidence: 99%

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A systematic review and meta-analysis of the association between angiotensin II type 1 receptor A1166C gene polymorphism and myocardial infarction susceptibility

Zheng

Shi

et al. 2012

J Renin Angiotensin Aldosterone Syst

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“…Three articles were excluded due to duplication of data [2,5,12]. Sixteen studies fulfilled the inclusion criteria and were selected for further data analysis [3,4,6–11,13–20].…”

mentioning

confidence: 99%

Association of the angiotensin type 1 receptor gene A1166C polymorphisms with myocardial infarction: a meta‐analysis

Zhang

Sun

Peng³

et al. 2011

Journal of Thrombosis and Haemostasis

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Angiotensin II plays an important role in the regulation of blood pressure and vascular homeostasis. However, overproduction of angiotensin II leads to multiple and diverse effects, including hypertension and atherosclerosis. All the above effects are mostly mediated by the angiotensin type 1 receptor (AT1R) [1]. The AT1R gene A1166C polymorphism has been considered an important factor in the risk of myocardial infarction (MI). In 1994, Tiret et al.[2] first reported the C-allele distribution in both MI cases and controls. Since then, studies both supporting and questioning this association have been published [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17], leading to uncertainty about the importance of this polymorphism. The aim of this study was to assess the association of the AT1R gene A1166C polymorphism and MI by performing a meta-analysis.We searched studies published in English using Medline (from 1966 to March 2011) and the following keywords: Ôangiotensin type 1 receptorÕ or ÔAT1RÕ or ÔAGT1RÕ, ÔpolymorphismÕ or Ôsingle nucleotide polymorphismÕ or ÔSNPÕ, and Ômyocardial infarctionÕ. References in retrieved articles were also searched. The inclusion criteria were as follows: (i) based on a case-control design; (ii) evaluation of the association of MI and A1166C polymorphism; and (iii) available genotype frequency. For studies with overlapping subjects, those with larger sample size were included. Two reviewers (H. Zhang and M. L. Sun) independently searched the articles and extracted information. Discrepancies were resolved, through discussion, by a third reviewer (J. Peng). The analyses were performed with the REVIEWER MANAGER 5.0.25 package (The Cochrane Collaboration, Oxford, UK).A total of 95 abstracts were identified. Of those, 19 studies were retrieved for more detailed evaluation. Three articles were excluded due to duplication of data [2,5,12]. Sixteen studies fulfilled the inclusion criteria and were selected for further data analysis [3,4,[6][7][8][9][10][11][13][14][15][16][17][18][19][20].In total, 6194 cases and 5716 controls were included from 16 studies. The overall distribution of genotypes in the controls was 57.3% AA, 35.9% AC and 6.8% CC, respectively. Compared with the AT1R AA genotype, subjects with the CC genotype showed a significantly higher risk of MI (odds ratio (OR) = 1.35; 95% confidence interval (CI), 1.05-1.73; P = 0.02) (Fig. 1A). Due to the low frequency of the CC genotype, we further compared the C allele carriers (AC/CC) with the AA genotype, which also revealed that individuals with the AC or CC genotype were more susceptible to MI (OR = 1.17; 95% CI, 1.04-1.31; P = 0.008) (Fig. 1B). Considering the deviation from Hardy-Weinberg equilibrium, we removed the study by Su et al. [13]. However, the pooled OR was not appreciably altered (CC vs. AA: OR = 1.38; 95% CI, 1.08-1.76; P = 0.01; AC/CC vs. AA: OR = 1.18; 95% CI, 1.05-1.33; P = 0.007) (Fig. 1C,D).The results of this meta-analysis suggest that the C allele of the AT1R gene A1166C polymorphism is associated with a...

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ATR1 A1166C (rs5186), FII G20210A (rs1799963), FV G1691A (rs6025), FXIII 97G > T (rs11466016) and MTHFR A1298C (rs1801131) polymorphisms and the risk of ST-elevation myocardial infarction in young Mexican individuals

Isordia-Salas,

Santiago-Germán,

Jiménez-Alvarado

et al. 2024

Mol Biol Rep

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Association between AT C573T polymorphism and cardiovascular risk factors in myocardial infarction

Cited by 4 publications

References 24 publications

A systematic review and meta-analysis of the association between angiotensin II type 1 receptor A1166C gene polymorphism and myocardial infarction susceptibility

A systematic review and meta-analysis of the association between angiotensin II type 1 receptor A1166C gene polymorphism and myocardial infarction susceptibility

Association of the angiotensin type 1 receptor gene A1166C polymorphisms with myocardial infarction: a meta‐analysis

ATR1 A1166C (rs5186), FII G20210A (rs1799963), FV G1691A (rs6025), FXIII 97G > T (rs11466016) and MTHFR A1298C (rs1801131) polymorphisms and the risk of ST-elevation myocardial infarction in young Mexican individuals

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