Association between atopic dermatitis and thyroid disease among U.S. adults in the 2001-2006 National Health and Nutrition Examination Survey

Smith, Brandon; Collier, M. R.; Devjani, Shivali; Han, George; Wu, Jashin J.

doi:10.1016/j.jaad.2022.10.017

Cited by 7 publications

(1 citation statement)

References 4 publications

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“…between AD and thyroid dysfunction in adults is limited, a study by Smith et al reported a significant association between the two, particularly in younger males, after accounting for potential confounders. 70 This connection may be due to shared immune dysregulation and cytokine pathways, and is further supported by overlapping genetic susceptibility loci. 71…”

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confidence: 99%

Association Between Atopic Dermatitis and Aging: Clinical Observations and Underlying Mechanisms

Chen,

Shen,

Cai

et al. 2024

JIR

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As one of the most prevalent chronic inflammatory skin diseases, atopic dermatitis (AD) increasingly affects the aging population. Amid the ongoing global aging trend, it's essential to recognize the intricate relationship between AD and aging. This paper reviews existing knowledge, summarizing clinical observations of associations between AD and aging-related diseases in various systems, including endocrine, cardiovascular, and neurological. Additionally, it discusses major theories explaining the correlation, encompassing skin-mucosal barriers, systemic inflammation and stress, genes, signal transduction, and environmental and behavioral factors. The association between AD and aging holds significant importance, both in population and basic perspectives. While further research is warranted, this paper aims to inspire deeper exploration of inflammation/allergy-aging dynamics and the timely management of elderly patients with AD.

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confidence: 99%

Association Between Atopic Dermatitis and Aging: Clinical Observations and Underlying Mechanisms

Chen,

Shen,

Cai

et al. 2024

JIR

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Revealing the causal relationship between thyroidectomy, thyroid function status, and eczema: a bidirectional two-sample Mendelian Randomization study

Yin,

Zhang

2024

Arch Dermatol Res

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This Mendelian Randomization (MR) study aims to explore the potential bidirectional causal relationship between thyroidectomy, thyroid function status, and eczema. We utilized summary statistics from genome-wide association studies of European ancestry for thyroidectomy (4360 cases and 458,573 controls), hyperthyroidism (2547 cases and 334,612 controls), and hypothyroidism (337,199 samples), employing genetic instruments to investigate their association with eczema (461,199 samples), and vice versa. Primary causal estimates were obtained using the inverse variance weighting method (IVW), with a series of sensitivity analyses conducted to assess the robustness of the results. The study found that genetically predicted thyroidectomy has a negative effect on eczema (OR = 0.645; 95% CI 0.498–0.837; P < 0.001), while neither hyperthyroidism nor hypothyroidism showed significant causal associations with eczema. Reverse Mendelian Randomization analysis indicated that genetically predicted eczema does not significantly affect the incidence of thyroidectomy, hyperthyroidism, or hypothyroidism. To correct for the impact of post-thyroidectomy hypothyroidism on eczema, a multivariable Mendelian Randomization analysis was performed, treating thyroidectomy and hypothyroidism as exposures and eczema as the outcome. After adjusting for hypothyroidism, thyroidectomy still reduced the risk of developing eczema (OR = 0.632; 95% CI 0.476–0.838; P = 0.001). This study elucidates the bidirectional causal relationship between thyroidectomy, thyroid function status, and eczema, providing ancillary scientific evidence on the influence of thyroidectomy on the mechanism of eczema development. Supplementary Information The online version contains supplementary material available at 10.1007/s00403-024-03591-z.

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Association of atopic dermatitis with Graves’ disease and Hashimoto’s thyroiditis: A case-control study in the All of Us research program

Joshi¹,

Bancroft²,

Garcia³

et al. 2023

Journal of the American Academy of Dermatology

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Association between atopic dermatitis and thyroid disease among U.S. adults in the 2001-2006 National Health and Nutrition Examination Survey

Cited by 7 publications

References 4 publications

Association Between Atopic Dermatitis and Aging: Clinical Observations and Underlying Mechanisms

Association Between Atopic Dermatitis and Aging: Clinical Observations and Underlying Mechanisms

Revealing the causal relationship between thyroidectomy, thyroid function status, and eczema: a bidirectional two-sample Mendelian Randomization study

Association of atopic dermatitis with Graves’ disease and Hashimoto’s thyroiditis: A case-control study in the All of Us research program

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