Association Between Basal Metabolic Rate and All-Cause Mortality in a Prospective Cohort of Southern Chinese Adults

Han, Fengyu; Hu, Feng; Wang, Tao; Zhou, Wei; Zhu, Linjuan; Huang, Xiao; Bao, Huihui; Cheng, Xiaoshu

doi:10.3389/fphys.2021.790347

Cited by 11 publications

(8 citation statements)

References 38 publications

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“…The results of this study show that BMR decreases nonlinearly with age, and the rate of decline accelerates with age, which is consistent with previous research (37). In the adult population in southern China, the increase in BMR was independently and negatively correlated with all-cause mortality among elderly male subjects (38); in particular, this is the first study to show that reduced BMR is an important risk factor for death among elderly individuals. In contrast, longlived people can maintain low-energy metabolism (39-41).…”

Section: Discussionsupporting

confidence: 91%

Normative reference data for body composition in healthy indigenous populations on the Qinghai-Tibet Plateau

Li²,

Huang³

et al. 2022

Front. Public Health

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Body composition represents an important aspect of physical fitness and has received increasing attention in recent years. The present study was designed and conducted to provide reference values for age-, sex-, and altitude-specific body composition for healthy indigenous Tibetan adults living on the Qinghai-Tibet Plateau, which has not yet been studied. A cross-sectional survey was conducted among 2,356 healthy Tibetan adults (1,433 females and 923 males) living on the Qinghai-Tibet Plateau for generations. The body composition of the participants was measured by bioelectrical impedance analysis (BIA). The measurements included weight, basal metabolic rate (BMR), fat-free mass (FFM), skeletal muscle mass (SMM), protein mass (PM), bone mass (BM), fat mass (FM), percentage of body fat (PBF), subcutaneous fat mass (SFM), visceral fat mass (VFM), total body water (TBW), intracellular water (ICW), and extracellular water (ECW). Overall, males had greater FFM, SMM, PM, BM, and water mass, whereas females were high in fat mass. Participants from plains generally had higher body composition values, and PM, BM, FM and body water values decreased with increasing altitude, with the lowest values found in >4,000 m Shigatse. FFM, SMM, PM, and BM tended to decrease with increasing age, whereas fat mass and ECW tended to increase with increasing age. This study provides the first normative reference data of body composition for healthy indigenous individuals on the Qinghai-Tibet Plateau. These datasets are important for future research related to body composition. A considerable decrease in body composition values in > 4,000 m-altitude areas suggested that body composition cutoff values should be established by altitude. Age-, sex-, and altitude-specific alterations in body composition values also inform the prevention and amendment of abnormal body composition changes and resultant health complications.

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Section: Discussionsupporting

confidence: 91%

Normative reference data for body composition in healthy indigenous populations on the Qinghai-Tibet Plateau

Li²,

Huang³

et al. 2022

Front. Public Health

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“…65-70 years of age. In a Chinese cohort aged above 60 years at the onset of the study (Han, Hu et al 2022), the decrease in the basal metabolic rate markedly accelerated after 6 years of follow up. Agespeci c world records in different track-and-eld and weight-lifting disciplines decrease more rapidly at ages above 70 than before (Berthelot, Bar-Hen et al 2019).…”

Section: Discussionmentioning

confidence: 96%

A previously unrecognized peculiarity of late-life human mortality kinetics?

Golubev

2023

Preprint

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The late-life mortality kinetics in several species features the deceleration of mortality rate increase with age, which in humans starts at ca. 90 years. Being analyzed based on the Gompertz law µ(t)=µ0*e^gt with its inbuilt linearity of the dependency of lnµ(t) on t, this feature is interpreted as reflecting the heterogeneity of a population where the frailer subjects die out earlier thus increasing the proportion of those whose dying out is slower and leading to a decrease in the demographic (actuarial) rate of aging. Using Human Mortality Database data related to France, Sweden and Japan in the periods 2020 and 1920 and to the cohorts born in 1920, it is shown in the present communication that the putative deceleration of the demographic (actuarial) rate of aging in humans is preceded by an acceleration, which starts at about 65 years, reaches a peak, which at about 85 years is ca. 30% higher than the pre-acceleration level, and decelerates thereafter until 90 years at least, when the pre-acceleration level is reached. This peculiarity cannot be explained with the predominant dying out of frailer subjects at earlier ages. Its plausible explanation may be the real acceleration of the (averaged) biological aging in humans at ages above 65-70 years, which conspicuously coincide with retirement. The biological implications of this finding are discussed in terms of the generalized Gomperts-Makeham law µ(t)=C(t)+µ0e^f(t). In particular, the deceleration of mortality increase in the oldest-old subjects may be contributed to by the actual biological deceleration of aging.

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“…Observational studies have suggested that higher BMR predicts mortality in young individuals 8 , 9 but lower mortality in old individuals 10 . Somewhat counter-intuitively, associations that change with age at recruitment may indicate causality because each successively older age group are more strongly selected survivors of a harmful exposure 11 .…”

Section: Introductionmentioning

confidence: 99%

“…A study in mice suggested that the observational association of BMR with lifespan could be confounded by fat mass 12 . Notably, body composition was not adjusted for in some of the human studies assessing the association of BMR with mortality 9 , 10 . Some forms of physical activity, such as resistance training but not aerobic exercise, have been shown to increase BMR 13 , but cannot be comprehensively assessed and adjusted for adequately, as seen in previous human studies on the same topic 9 , 10 , 14 .…”

Section: Introductionmentioning

confidence: 99%

“…Notably, body composition was not adjusted for in some of the human studies assessing the association of BMR with mortality 9 , 10 . Some forms of physical activity, such as resistance training but not aerobic exercise, have been shown to increase BMR 13 , but cannot be comprehensively assessed and adjusted for adequately, as seen in previous human studies on the same topic 9 , 10 , 14 . People with metabolic disorders, such as type 2 diabetes, have a higher BMR than those without 15 , 16 and are also at a higher risk of mortality, although a change in BMR could have occurred due to latent metabolic disruption making it look as if BMR caused the disease 17 , 18 .…”

Section: Introductionmentioning

confidence: 99%

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Effect of basal metabolic rate on lifespan: a sex-specific Mendelian randomization study

Schooling

2023

Sci Rep

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Observationally, the association of basal metabolic rate (BMR) with mortality is mixed, although some ageing theories suggest that higher BMR should reduce lifespan. It remains unclear whether a causal association exists. In this one-sample Mendelian randomization study, we aimed to estimate the casual effect of BMR on parental attained age, a proxy for lifespan, using two-sample Mendelian randomization methods. We obtained genetic variants strongly (p-value < 5 × 10–8) and independently (r2 < 0.001) predicting BMR from the UK Biobank and applied them to a genome-wide association study of parental attained age based on the UK Biobank. We meta-analyzed genetic variant-specific Wald ratios using inverse-variance weighting with multiplicative random effects by sex, supplemented by sensitivity analysis. A total of 178 and 180 genetic variants predicting BMR in men and women were available for father’s and mother’s attained age, respectively. Genetically predicted BMR was inversely associated with father’s and mother’s attained age (years of life lost per unit increase in effect size of genetically predicted BMR, 0.46 and 1.36; 95% confidence interval 0.07–0.85 and 0.89–1.82), with a stronger association in women than men. In conclusion, higher BMR might reduce lifespan. The underlying pathways linking to major causes of death and relevant interventions warrant further investigation.

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Association Between Basal Metabolic Rate and All-Cause Mortality in a Prospective Cohort of Southern Chinese Adults

Cited by 11 publications

References 38 publications

Normative reference data for body composition in healthy indigenous populations on the Qinghai-Tibet Plateau

Normative reference data for body composition in healthy indigenous populations on the Qinghai-Tibet Plateau

A previously unrecognized peculiarity of late-life human mortality kinetics?

Effect of basal metabolic rate on lifespan: a sex-specific Mendelian randomization study

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