Association between baseline and changes in high-sensitive C-reactive protein and metabolic syndrome: a nationwide cohort study and meta-analysis

Xue, Qingping; Yang, Xue; Huang, Yuli; Zhu, Dongshan; Wang, Yi; Wen, Ying; Zhao, Jian; Liu, Yanjun; Yang, Chunxia; Ju, Ke; Yan, Tao

doi:10.1186/s12986-021-00632-6

Cited by 14 publications

(15 citation statements)

References 39 publications

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“…In a cross-sectional study, the dietary patterns characterized by low intake of olive oil, vegetables, legumes, soups, fruits, fish, and high intake of red meat, animal fats, alcohol, which were generated using principal factor analysis, were associated with both CRP and cardiovascular disease risk profile in the health [9]. Additionally, the participants with the highest quartile of hs-CRP were reported to have a 1.83-fold higher risk than those with the lowest in a previous cohort study [20], which supported the findings of the current study. Therefore, it was of public health significance to identify the dietary patterns that could affect CRP levels and therefore lower the risk of MetS.…”

Section: Comparison With Previous Studiesmentioning

confidence: 97%

Association between Dietary Patterns Reflecting C-Reactive Protein and Metabolic Syndrome in the Chinese Population

Wen

et al. 2022

Nutrients

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It is unclear how the dietary patterns reflecting C-reactive protein (CRP) affect metabolic syndrome (MetS) in the Chinese population. To examine the effect of the dietary pattern reflecting CRP with MetS, a cross-sectional study was based on the health checkup data from the Beijing MJ Health Screening Centers between 2008 and 2018. The CRP-related dietary pattern was derived from 17 food groups using reduced-rank regression. Participants were divided into five groups according to the quintiles of dietary pattern score. Multivariate logistic regression was then applied to estimate the odds ratios (OR) and 95% confidence intervals (CIs) for the quintiles of diet pattern score related to MetS and its four components. Of the 90,130 participants included in this study, 11,209 had MetS. A CRP-related dietary pattern was derived, characterized by a higher consumption of staple food, fresh meat, processed products, and sugar-sweetened beverages but a lower intake of honey and jam, fruits, and dairy products. Compared with participants in the lowest quintile (Q1), participants in the higher quintiles were associated with increased risks of MetS in a dose–response manner after adjustment for potential confounders (P for linear trend < 0.001), the ORs for Q2 to Q5 were 1.10 (95%CI: 1.02–1.19), 1.14 (95% CI: 1.05–1.22), 1.23 (95%CI: 1.15–1.33), and 1.49 (95%CI:1.38–1.61), respectively. Moreover, the effects were stronger among individuals aged 50 years or older. A CRP-related dietary pattern was associated with the risk of MetS. It provides new insights that dietary intervention to achieve a lower inflammatory level could potentially prevent MetS.

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Section: Comparison With Previous Studiesmentioning

confidence: 97%

Association between Dietary Patterns Reflecting C-Reactive Protein and Metabolic Syndrome in the Chinese Population

Wen

et al. 2022

Nutrients

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“…Although MetS is associated with increased plasma CRP [2], our participants maintained lower concentrations throughout the intervention. Vegetarian and vegan diets are negatively correlated with CRP [12,32,34].…”

Section: Discussionmentioning

confidence: 65%

“…MetS, characterized by insulin resistance, hypertension, abdominal obesity, and dyslipidemia, triggers the alteration of cell signaling pathways, resulting in increased levels of inflammatory markers, lipid peroxides, and free radicals, causing cell damage and eventually leading to the clinical symptoms of the condition. Elevated products of oxidative stress as well as inflammatory markers, C-reactive protein (CRP) [2], tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) [3] have been documented to contribute to the pathogenesis of MetS [4].…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Eggs in a Plant-Based Diet on Oxidative Stress and Inflammation in Metabolic Syndrome

et al. 2022

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We recently reported that the inclusion of whole eggs in plant-based diets (PBD) increased plasma choline, lutein, and zeaxanthin in individuals with metabolic syndrome (MetS). The objective of the current study was to evaluate whether this dietary pattern would protect against oxidative stress and low-grade inflammation, two common characteristics of MetS. We recruited 24 men and women with MetS, who, after following a PBD for 2 weeks (baseline), were randomly allocated to consume either two whole eggs with 70 g of spinach/day (EGG) or the equivalent amount of egg substitute with spinach (SUB) as breakfast for 4 weeks. After a 3-week washout, they were allocated to the alternate breakfast. We measured biomarkers of oxidation and inflammation at baseline and at the end of each intervention. Tumor necrosis factor-alpha, interleukin-6, monocyte protein attractant-1, liver enzymes, and C-reactive protein, as well as total antioxidant capacity, paraoxonase-1 (PON-1) activity, and other biomarkers of oxidation were not different at the end of EGG or SUB or when compared to baseline. However, plasma malondialdehyde (MDA) concentrations were lower (p < 0.05) during the EGG and baseline compared to SUB. In addition, the increases in dietary lutein and zeaxanthin previously observed had a strong positive correlation with PON-1 activity (r = 0.522, p < 0.01) only during the EGG period, whereas plasma zeaxanthin was negatively correlated with MDA (r = −0.437, p < 0.01). The number of participants with MetS was reduced from 24 during screening to 21, 13, and 17 during the BL, EGG, and SUB periods, respectively, indicating that eggs were more effective in reversing the characteristics of MetS. These data suggest that adding eggs to a PBD does not detrimentally affect inflammation or oxidative stress; on the contrary, eggs seem to provide additional protection against the biomarkers that define MetS.

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“…The epidemiological evidence highlighted that diabetes is linked to the augmented concentrations of several inflammatory markers, namely CRP, IL-6, and TNF-α (5, 7-9, 15, 16). Several studies have also scrutinized the relationship between MetSyn, as a major causative factor for CVDs, and inflammatory mediators (1,(17)(18)(19)(20). Additionally, given their metabolic activities, adipocytes could contribute to the production of various adipokines and pro-inflammatory mediators.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Markers and Atherogenic Coefficient: Early Markers of Metabolic Syndrome

Mahdavi-Roshan

Shoaibinobarian

Noormohammadi

et al. 2022

Int J Endocrinol Metab

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Background: Considering the close link between metabolic syndrome (MetSyn) and cardiovascular diseases, considerable attention has been devoted to the identification of their shared underlying pathological mechanisms in recent decades. Objectives: This study aimed to investigate the association between pro-inflammatory factors and newly-diagnosed MetSyn. Methods: This case-control study recruited obese and nonobese individuals who were newly diagnosed with MetSyn (cases, n = 84) and healthy individuals (controls, n = 83). The medical and sociodemographic data of the participants were collected on enrollment. Serum analysis was performed to ascertain the concentrations of tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), fasting blood sugar (FBS), total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and atherogenic coefficient (AC). Multiple regression analysis was carried out to explore the relationship between inflammatory markers and AC with MetSyn odds. The Pearson correlation test was also performed to investigate the correlations between metabolic and inflammatory parameters. Results: Positive relationships were observed between the serum levels of TNF-α and CRP with the odds of MetSyn following controlling for confounders (adjusted odds ratio [AOR] = 1.32; 95% confidence interval [CI]: 1.01 - 1.72; AOR = 1.29; 95% CI: 1.18 - 1.41; respectively, P ≤ 0.03). Additionally, higher AC was accompanied by increased odds of MetSyn (AOR = 1.98; 95% CI: 1.31 - 2.98; P = 0.001). The Pearson correlation analysis also showed positive correlations between TNF-α levels and serum metabolic abnormalities, including elevated LDL-C, FBS, and AC and lowered HDL-C levels (P ≤ 0.02). Conclusions: The present results revealed that higher serum concentrations of pro-inflammatory and atherogenic indices, including CRP, TNF-α, and AC, might be associated with elevated odds of newly diagnosed MetSyn regardless of potential confounders, particularly body mass index. The obtained findings might be moderated by the positive correlations observed between serum TNF-α, as the chronic inflammatory state indicator, and impaired lipid and glycemic markers.

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Association between baseline and changes in high-sensitive C-reactive protein and metabolic syndrome: a nationwide cohort study and meta-analysis

Cited by 14 publications

References 39 publications

Association between Dietary Patterns Reflecting C-Reactive Protein and Metabolic Syndrome in the Chinese Population

Association between Dietary Patterns Reflecting C-Reactive Protein and Metabolic Syndrome in the Chinese Population

The Effects of Eggs in a Plant-Based Diet on Oxidative Stress and Inflammation in Metabolic Syndrome

Inflammatory Markers and Atherogenic Coefficient: Early Markers of Metabolic Syndrome

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