Association Between Before-bedtime Passive Body Heating and Nocturia During the Cold Season Among Older Adults

Tai, Yoshiaki; Obayashi, Kenji; Okumura, Kazuki; Yamagami, Yuki; Negoro, Hiromitsu; Kurumatani, Norio; Saeki, Keigo

doi:10.2188/jea.je20210471

Cited by 2 publications

(1 citation statement)

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“…Appropriate guidance and medications should be provided while behavior and lifestyle modifications, such as fluid/caffeine restriction and leg elevation in the evening, stockings for peripheral edema, pelvic floor muscle training, delayed voiding, and urge suppression 26 may be useful. Additionally, clear circadian boundaries in activities, such as exercise in the evening 27 , taking a bath 1–2 h before bedtime 28 , and light exposure in the morning 29 could reduce nocturnal urination and may prevent incident poor sleep and disruption of deep sleep, thereby extending healthy life expectancy. Desmopressin administration to patients with nocturnal polyuria has additionally been shown to significantly improve both nocturia and the duration of the first sleep period 30 .…”

Section: Discussionmentioning

confidence: 99%

Risk analyses of nocturia on incident poor sleep and vice versa: the Nagahama study

Negoro¹,

Setoh²,

Fukunaga³

et al. 2023

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Cross-sectional relationships between nocturia and sleep problems have been well evaluated but the risk association for each incidence is scarcely reported. This analysis included 8076 participants of the Nagahama study in Japan (median age 57, 31.0% male) and associations between nocturia and self-reported, sleep-related problems (poor sleep) were evaluated cross-sectionally. Causal effects on each new-onset case were analyzed longitudinally after 5 years. Three models were applied: univariable analysis, adjustment for basic variables (i.e., demographic and lifestyle variables) and full adjustment for basic and clinical variables. The overall prevalences of poor sleep and nocturia were 18.6% and 15.5%, while poor sleep was positively associated with nocturia (OR = 1.85, p < 0.001) and vice versa (OR = 1.90, p < 0.001). Among 6579 good sleep participants, 18.5% developed poor sleep. Baseline nocturia was positively associated with this incident poor sleep (OR = 1.49, p < 0.001, full adjustment). Among 6824 non-nocturia participants, the nocturia incidence was 11.3%. Baseline poor sleep was positively associated with this incident nocturia (OR = 1.26, p = 0.026); such associations were significant only in women (OR = 1.44, p = 0.004) and under-50-year-old groups (OR = 2.82, p < 0.001), after full adjustment. Nocturia and poor sleep associate with each other. Baseline nocturia can induce new-onset poor sleep while baseline poor sleep may induce new-onset nocturia only in women.

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Section: Discussionmentioning

confidence: 99%

Risk analyses of nocturia on incident poor sleep and vice versa: the Nagahama study

Negoro¹,

Setoh²,

Fukunaga³

et al. 2023

Sci Rep

Self Cite

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Efficacy and Safety of Lemborexant for Insomnia Patients With Nocturia—A Prospective Study

Togo,

Kaizuka,

Nagasawa

et al. 2024

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ObjectivesNocturia is considered a clinical problem when nocturnal urinary frequency is two or more times. For affected patients, development of depression, falling, and increased mortality rate are matters of concern. The present study investigated the efficacy and safety of lemborexant for insomnia patients with nocturia.MethodsInsomnia patients (Athens Insomnia Scale [AIS] ≥ 6) who typically awoke twice or more during the night to urinate and were examined at our institutions from June 2021 to December 2022 were enrolled. Each was administrated 5 mg of lemborexant, one tablet, daily for 4 weeks. Total AIS score, nocturia frequency, individual frequency‐volume chart findings, and N‐QOL score were examined before and after administration.ResultsOf the 37 patients recruited, 5 were excluded, thus 32 were enrolled and subjected to analyses. Following lemborexant therapy, the mean AIS total score was significantly decreased from 11.4 to 7.8 (p < 0.01) as was mean number of nocturia episodes from 3.4 to 2.3 (p < 0.001). Furthermore, the mean single voided urine volume at night was significantly increased from 182.5 to 225.3 mL (p < 0.001)and mean period of undisturbed sleep was significantly extended from 105.3 to 174.8 min (p < 0.001), while mean total N‐QOL score was significantly improved from 49.6% to 64.8% (p < 0.001). As for adverse events, mild somnolence was observed in three cases.ConclusionsLemborexant may be effective and safe for use in insomniac patients with nocturia.

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Association Between Before-bedtime Passive Body Heating and Nocturia During the Cold Season Among Older Adults

Abstract: This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record.

Cited by 2 publications

References 31 publications

Risk analyses of nocturia on incident poor sleep and vice versa: the Nagahama study

Risk analyses of nocturia on incident poor sleep and vice versa: the Nagahama study

Efficacy and Safety of Lemborexant for Insomnia Patients With Nocturia—A Prospective Study

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