Association between being underweight and excess body weight before SARS coronavirus type 2 infection and clinical outcomes of coronavirus disease 2019: Multicenter study

Estatística Cardiovascular – Brasil 2023

“…•A pandemia de COVID-19 levou a observações em todo o mundo da associação entre obesidade e desfechos adversos nos indivíduos infectados. 382 - 386 Em estudo multicêntrico de base hospitalar com 8.183 pacientes admitidos em UTI que testaram positivo para SARS-CoV-2, 387 ao estratificar por categorias de IMC e ajustando para idade, sexo e status de tabagismo, os pacientes com obesidade grave mostraram maior risco de mortalidade por COVID-19 (HR 1,21; IC 95%, 1,03–1,43) em comparação àqueles com ‘peso normal/sobrepeso’. Não houve diferença para as categorias ‘obesidade leve/moderada’ (HR 0,91; IC 95%, 0,83–1,00) e ‘peso abaixo do normal’ (HR 1,21; IC 95%, 0,80–1,81).…”

“…•Por outro lado, estudo de coorte multicêntrico conduzido em oito estados da região Nordeste, GENSCoV-BR, 386 analisou os dados demográficos, clínicos e antropométricos de indivíduos que testaram positivo para SARS-CoV-2, além dos desfechos que incluíram hospitalização, ventilação mecânica e morte, para avaliar os efeitos dos extremos de peso corporal nos desfechos clínicos. Dentre 1.308 indivíduos, excesso de peso corporal foi observado em 66,9%, baixo peso em 2,7% e obesidade em 32,4%, de acordo com a classificação da OMS.…”

“…•The COVID-19 pandemic led to worldwide observations of the association between obesity and adverse outcomes of infected individuals. 382 - 386 In a hospital-based, multicenter study of 8183 ICU hospitalized patients who tested positive for SARS-CoV-2, 387 when stratifying by BMI categories and adjusting for age, sex, and smoking status, the patients with severe obesity showed an increased risk for COVID-19 mortality (HR 1.21; 95% CI, 1.03–1.43) compared to those with normal/overweight. No difference was observed for the mild/moderate obese (HR 0.91; 95% CI, 0.83–1.00) and underweight (HR 1.21; 95% CI, 0.80–1.81) categories.…”

“…•On the other hand, a multicenter cohort study conducted in eight different states in Northeastern Brazil, GENSCoV-BR, 386 has analyzed demographic, clinical, and anthropometric data of individuals who tested positive for SARS-CoV-2, as well as outcomes including hospitalization, mechanical ventilation, and death, to assess the effects of extremes in body weight on clinical outcomes. Among 1308 individuals, excess body weight was observed in 66.9%, underweight in 2.7%, and obesity in 32.4%, according to the WHO classification.…”

The Role of Nutrition in Mitigating the Effects of COVID-19 from Infection through PASC

“…A total of 174,568 adults with COVID-19 were included and obesity was independently associated with higher clinical severity of COVID-19 (odds ratio 1.36). It is worthwhile to mention a conflicting report from a multi-center trial conducted across Brazil, which did not find a relationship between BMI and COVID-19 infection severity [ 11 ]. One explanation for this could be the relatively insensitive regression model used, which did not account for admission month, hospital urbanicity, insurance/payer type, or other previously identified confounding factors [ 12 ].…”