Association between biomarkers of bone health and osteosarcopenia among Iranian older people: The Bushehr Elderly Health (BEH) program

Fathi, Mojtaba; Heshmat, Ramin; Ebrahimi, Mehdi; Salimzadeh, Ahmad; Ostovar, Afshin; Fathi, Ali; Razi, Farideh; Nabipour, Iraj; Moghaddassi, Maryam; Shafiee, Gita

doi:10.1186/s12877-021-02608-w

Cited by 11 publications

(6 citation statements)

References 53 publications

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“…Additionally, the biochemical assessment of bone and muscle metabolism has been proposed to improve early diagnosis and screening, and assess the response to therapies in people with OS. Fathi and colleagues [ 29 ] investigated the association of bone turnover markers such as osteocalcin (OC), C-terminal cross-linked telopeptide (CTX), tartrate-resistant acid phosphatase (TRAP), alkaline phosphatase bone (BALP), and other factors such as vitamin D, calcium, phosphorus, and alkaline phosphatase with OS in 400 elderly people. The study results showed a statistically significant difference in OC, CTX, and TRAP between osteosarcopenia (−) and osteosarcopenia (+) people.…”

Section: Diagnostic Criteriamentioning

confidence: 99%

Osteosarcopenia: A Narrative Review on Clinical Studies

Polito¹,

Barnaba²,

Ciarapica³

et al. 2022

IJMS

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Osteosarcopenia (OS) is defined by the concurrent presence of osteopenia/osteoporosis and sarcopenia. The pathogenesis and etiology of OS involve genetic, biochemical, mechanical, and lifestyle factors. Moreover, an inadequate nutritional status, such as low intake of protein, vitamin D, and calcium, and a reduction in physical activity are key risk factors for OS. This review aims to increase knowledge about diagnosis, incidence, etiology, and treatment of OS through clinical studies that treat OS as a single disease. Clinical studies show the relationship between OS and the risk of frailty, falls, and fractures and some association with Non-communicable diseases (NCDs) pathologies such as diabetes, obesity, and cardiovascular disease. In some cases, the importance of deepening the related mechanisms is emphasized. Physical exercise with adequate nutrition and nutritional supplementations such as proteins, Vitamin D, or calcium, represent a significant strategy for breaking OS. In addition, pharmacological interventions may confer benefits on muscle and bone health. Both non-pharmacological and pharmacological interventions require additional randomized controlled trials (RCT) in humans to deepen the synergistic effect of exercise, nutritional interventions, and drug compounds in osteosarcopenia.

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Section: Diagnostic Criteriamentioning

confidence: 99%

Osteosarcopenia: A Narrative Review on Clinical Studies

Polito¹,

Barnaba²,

Ciarapica³

et al. 2022

IJMS

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“…The high prevalence of DS in this Iranian elderly community shows the importance of conducting such studies and implementing relevant interventions to address contributory factors. Also in these subjects we found a higher risk of osteosarcopenia, risk of falls and fractures [ 56 ]. This study examined a large sample of older people in Iran using an established protocol, including that we evaluated both measured body composition indices of different anthropometric indices and DXA with standard methods.…”

Section: Discussionmentioning

confidence: 99%

The association of body composition and fat distribution with dysmobility syndrome in community-dwelling older adults: Bushehr Elderly Health (BEH) program

Khaleghi,

Emamat,

Marzban

et al. 2023

BMC Musculoskelet Disord

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Background and objective Dysmobility Syndrome (DS) is characterized as an accumulation of clinical risk factors for functional disability, such as osteoporosis, sarcopenia, and obesity. Neurological disorders that affect the motor and sensory systems can also contribute to the condition, resulting in gait and muscle strength disturbances, as well as a history of falls and fractures. The study aimed to determine the association between fat distribution in different body areas and the odds of older adults developing DS, as there is still uncertainty about the accumulation of fat in which area is most closely linked to the condition. Methods This cross-sectional study was conducted according to the data from the second phase of the Bushehr Elderly Health Cohort (BEH). Dysmobility Syndrome was defined based on the co-occurrence of at least three outcomes of its criteria. Body composition was measured using dual-energy X-ray absorptiometry (DXA) and anthropometric studies. For evaluating the relationship, multivariate logistic regression and adjusted univariate linear regression were used. Results Of 2,359 who were recruited in the study, 1,277 participants (54.13%) had DS. According to the final logistic regression model in the limb region, FM and FM to FFM ratios were significantly associated with DS [OR (95%CI) = 1.04 (1.02 to 1.05), and 3.42 (1.95 to 5.99), respectively]. Also, In the trunk region, the FM and FM to FFM ratio were significantly related to the odds of DS, although this relationship was weaker than in the limbs region [OR (95%CI) = 1.02 (1.00 to 1.03), and 2.45 (1.36 to 4.39), respectively]. Conclusion Our findings indicate that a higher regional and whole-body amount of fat mass rather than fat-free mass is closely linked to an increased risk of DS, particularly in the elderly population. Notably, higher fat mass in the limbs (especially in the legs) is associated with greater odds of DS, while a higher android-to-gynoid fat mass ratio is associated with lower DS risk. Screening fat mass distribution in older individuals can be a valuable strategy for promptly diagnosing DS, implementing interventions to prevent disabilities, and improving their quality of life.

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“…These indicators, including ALP, TRAP, OC, OCIF, ODF, have been previously reported to play crucial roles in bone remodeling. 38 For example, ALP and TRAP are markers of osteoblast and osteoclast activity, respectively, while OC is a marker of bone formation. Therefore, their abnormal expression may contribute to the development of OFs by disrupting the balance of bone remodeling.…”

Section: Discussionmentioning

confidence: 99%

Association between circHIPK3/miR-378a-3p/HDAC4 axis and osteoporotic fractures: A comprehensive investigation

Wang,

Sheng,

Yao

2023

J Orthop Surg (Hong Kong)

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Background Osteoporotic fractures (OFs) are a significant public health issue, which can lead to pain and impaired mobility. The underlying mechanisms of OFs remain unclear, but recent studies have suggested that the circRNA-miRNA-mRNA pathway may play a crucial role. Purpose This study aimed to investigate the potential involvement of the circHIPK3/miR-378a-3p/HDAC4 pathway in the pathogenesis of OFs. Methods We collected tissue and serum samples from 10 patients with OFs and 10 healthy controls. The expression levels of circHIPK3, miR-378a-3p, and HDAC4 were measured by qPCR and WB. Additionally, we quantified the serum levels of bone metabolism-related indicators (ALP, OC, TRAP, OCIF, ODF) using ELISA. Results Our results revealed significant upregulation of circHIPK3 and HDAC4 in both tissue and serum samples from OF patients compared with controls. Simultaneously, we detected a lower expression level of miR-378a-3p in OF tissues and serum than that in the control group. Furthermore, the serum levels of bone metabolism-related indicators ALP, TRAP, OCIF, and ODF were significantly higher in OF patients than in the control group. Interestingly, the serum level of OCIF was lower in OF patients than in the control group. Conclusion Our study provides important evidence for the involvement of the circHIPK3/miR-378a-3p/HDAC4 pathway in the pathogenesis of OFs. The upregulation of circHIPK3 and HDAC4 and downregulation of miR-378a-3p observed in OF patients suggests their potential regulatory effects on bone metabolism. Meanwhile, abnormal expression of serum bone metabolism-related indicators may contribute to the development of OFs by disrupting the balance of bone remodeling.

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Association between biomarkers of bone health and osteosarcopenia among Iranian older people: The Bushehr Elderly Health (BEH) program

Cited by 11 publications

References 53 publications

Osteosarcopenia: A Narrative Review on Clinical Studies

Osteosarcopenia: A Narrative Review on Clinical Studies

The association of body composition and fat distribution with dysmobility syndrome in community-dwelling older adults: Bushehr Elderly Health (BEH) program

Association between circHIPK3/miR-378a-3p/HDAC4 axis and osteoporotic fractures: A comprehensive investigation

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