Association between biomarkers of inflammation and left ventricular hypertrophy in moderate chronic kidney disease

Cottone, Santina; Nardi, Emilio; Mulè, Giuseppe; Vadalà, Anna; Lorito, Maria Carmela; Riccobene, Raffaella; Palermo, Alessandro; Arsena, Rosalia; Guarneri, Marco; Cerasola, Giovanni

doi:10.5414/cnp67209

Cited by 65 publications

(59 citation statements)

References 32 publications

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“…18,19 In fetuin-A-deficient mice, the aorta was found to be devoid of calcification and fibrosis, whereas the peripheral vessels in the skin and kidney showed evidence of extensive calcification; furthermore, the small artery involvement preceded the impairment of renal function. 17,18,20 The data presented herein support the relationship between fetuin-A and IMT, suggesting that decreases in the fetuin-A level could have a role in the development of the vascular changes that are peculiar to hypertensive patients; this role appears to be independent of other confounding factors, such as renal function. Nevertheless the results of this study are not an unambiguous demonstration for the causative role of fetuin-A.…”

Section: Discussionsupporting

confidence: 71%

Subclinical atherosclerosis and fetuin-A plasma levels in essential hypertensive patients

et al. 2012

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The intima-media thickness (IMT) is considered as a surrogate marker for atherosclerotic disease. The aim of this study was to analyze the relationship of carotid IMT with fetuin-A in patients with essential hypertension (EH) and normal renal function. The plasma levels of fetuin-A, interleukin 6 (IL-6), tumor necrosis factor-a (TNF-a) and the biomarker of oxidative stress 8-isoPGF2alpha were assayed in samples from 105 untreated EH patients. Carotid IMT measurements were also performed. EH was studied overall and after dividing in EH with IMT X and o0.9 mm. All of the biomarkers were significantly different between the two subgroups, in particular, the fetuin-A level was lower in the patients with an IMT X0.9 mm. In the overall group, the linear analysis of correlation demonstrated that the IMT was significantly inversely correlated with the fetuin-A level (r ¼ À0.40, Po0.0001) and directly with TNF-a (r ¼ 0.39, Po0.0001), IL-6 (r ¼ 0.38, Po0.0001) and 8-iso-PGF2alpha (r ¼ 0.356, Po0.0003). The multiple regression analysis performed that assigned IMT as a dependent variable showed that fetuin-A (b ¼ À0.268, Po0.0001) was independently correlated with the IMT. Receiver-operator curves demonstrated that fetuin-A levels have a predictive power of IMT40.9 mm (AUC (area under the curve) 0.738, Po0.0001). Our results suggest that in EH, fetuin-A is associated with the IMT independently of oxidative stress and renal function, thus predicting increases in the IMT.

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Section: Discussionsupporting

confidence: 71%

Subclinical atherosclerosis and fetuin-A plasma levels in essential hypertensive patients

et al. 2012

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“…However, we believe we covered typical times for routine practice. Fourth, the levels of CRP and ESR are influenced by the presence of systemic conditions [6,9,18,24]. In our study, we found no differences in the prevalence of the systemic conditions between the unilateral and staged bilateral groups.…”

Section: Discussioncontrasting

confidence: 39%

“…The data on the fortysecond and ninetieth postoperative days only were compared between the unilateral and the second knee bilateral groups. Because the levels of CRP and ESR are influenced by the presence of other systemic conditions (diabetes mellitus, cardiac diseases, chronic lung and kidney disease, and cancers) [6,9,18,24], proportions of patients with the systemic conditions were compared between the unilateral and the staged bilateral groups. There were no differences in the prevalence of systemic conditions between the unilateral and staged bilateral groups (20.3% versus 27.9%; p [ 0.05, chi square test).…”

Section: Methodsmentioning

confidence: 99%

Normative Temporal Values of CRP and ESR in Unilateral and Staged Bilateral TKA

Park

Kim

Chang

et al. 2008

Clinical Orthopaedics &Amp; Related Research

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C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) play helpful roles in determining the presence of infection after TKA. To provide baseline values, we documented normative temporal values of CRP and ESR in unilateral and staged bilateral TKAs for osteoarthritis. Levels of CRP and ESR were evaluated before surgery and on the first, second, fifth, seventh, fourteenth, forty-second, and ninetieth postoperative days in 320 uncomplicated primary TKAs. C-reactive protein and ESR levels were compared in three groups: unilateral (108 knees), first knee bilateral (106 knees), and second knee bilateral (106 knees) groups. All three groups exhibited similar temporal patterns. Mean CRP levels increased rapidly, reaching a peak on the second day and decreased to less than the normal reference level on the forty-second day. They returned to preoperative levels on the ninetieth day. Mean ESR levels peaked on the fifth day and returned close to the preoperative levels only on the ninetieth day. Wide variations were observed and many cases (43%) did not follow the typical patterns. C-reactive protein had greater fold changes, less frequent atypical temporal patterns, and lower correlation between preoperative and postoperative levels than ESR. Our findings should help surgeons interpret CRP and ESR to determine the presence of infection after TKA.

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“…In particular, it has been claimed that these factors have a role of the development of LVH in dialysis patients. [9,15] LVH is an important indicator of increased cardiovascular risk in ESRD patients [10] ; therefore, it is very important to define the factors leading to development of LVH. Visfatin, which is suggested to be related to inflammation and endothelial dysfunction, may be responsible of the Comparison of IL-6 serum levels between CAPD and hemodialysis patients and healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

“…[3,6] Increased levels of IL-6 and TNF-α have been demonstrated to be related with left ventricular hypertrophy (LVH) in dialysis patients. [8][9][10] This suggests a relationship between visfatin, which is thought to be a proinflammatory cytokine, and LVH, though such a relationship has not yet been explored in the literature.…”

Section: Introductionmentioning

confidence: 99%

The Relationship of Visfatin Levels to Inflammatory Cytokines and Left Ventricular Hypertrophy in Hemodialysis and Continuous Ambulatory Peritoneal Dialysis Patients

Erten

Ebinç

et al. 2008

Renal Failure

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Visfatin was recently defined as an adipocytokine; however, the pathophysiological role of visfatin is not completely understood. A few studies suggest that visfatin may be a new proinflammatory adipocytokine. The aim of the present study was to compare serum visfatin levels between hemodialysis and continuous ambulatory peritoneal dialysis (CAPD) patients and evaluate the relationship between visfatin levels to IL-6, TNF-α, and left ventricular hypertrophy. Serum visfatin, IL-6, and TNF-α levels were measured by using the ELISA method, and echocardiographic evaluations were performed in 31 hemodialysis patients, 30 CAPD patients, and 21 healthy volunteers. Serum visfatin levels were higher in the CAPD group (265.27 ± 387.86 ng/mL) than hemodialysis (97.68 ± 244.96 ng/mL,) and control (41.33 ± 48.87 ng/mL) groups (p = 0.04, p = 0.01, respectively). No significant difference was observed between the hemodialysis and control groups. In univariate analysis, visfatin levels were positively correlated with IL-6 (r = 0.24, p = 0.03), TNF-α (r = 0.34, p = 0.002), and BMI (r = 0.26, p = 0.03) and negatively correlated with some left ventricular diastolic parameters [Em and Em/Am (r = −0.305, p = 0.01), (r = −0.251, p = 0.03), respectively]. No relationship was found between visfatin and left ventricular mass index. In the linear regression analysis, visfatin levels independently related with TNF-( (β = 0.369, p = 0.001) and p = 0.015). This study has found significantly higher levels of serum visfatin in CAPD patients when compared to healthy individuals. Increased visfatin levels seem to associate with proinflammatory cytokines such as IL-6 or TNF-α. As for the effects of on left ventricular structure and functions, visfatin might have negative effects on left ventricular diastolic function parameters but have no effects on left ventricular mass index.

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Association between biomarkers of inflammation and left ventricular hypertrophy in moderate chronic kidney disease

Cited by 65 publications

References 32 publications

Subclinical atherosclerosis and fetuin-A plasma levels in essential hypertensive patients

Subclinical atherosclerosis and fetuin-A plasma levels in essential hypertensive patients

Normative Temporal Values of CRP and ESR in Unilateral and Staged Bilateral TKA

The Relationship of Visfatin Levels to Inflammatory Cytokines and Left Ventricular Hypertrophy in Hemodialysis and Continuous Ambulatory Peritoneal Dialysis Patients

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