Association between birth weight, body mass index and IGF2/ApaI polymorphism

Gomes, M.V.; Soares, Milena Rodrigues; Pasqualim-Neto, A.; Marcondes, C. R.; Lobo, Richard Roberto; Ramos, Ester Silveira

doi:10.1016/j.ghir.2005.06.016

Cited by 35 publications

(25 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, the observed genotype frequencies were similar to those reported in other Caucasian populations. 21,[23][24][25][26][27][28] The 1156T4C SNP has thus far only been examined in two studies that reported conflicting genotype frequencies. 27,28 Our genotype frequencies were in agreement with those reported by Heude et al…”

Section: Discussionmentioning

confidence: 99%

“…16,17 As impaired fetal growth is a risk factor for adult metabolic diseases, 18 genes like IGF2 are attractive candidates to explain susceptibility to disorders such as T2D and obesity, and accordingly several association studies have been conducted. [19][20][21][22][23][24][25][26][27][28][29] In a sample of British middle-aged men, the minor allele of the 820G4A (ApaI) single nucleotide polymorphism (SNP) located in the 3 0 untranslated region of the IGF2 gene was associated with lower body mass, lower body mass index (BMI) and higher IGF2 levels. 20,21 Although the association with lower BMI was replicated in an Israeli sample, 22 several studies failed to confirm this.…”

Section: Introductionmentioning

confidence: 99%

“…20,21 Although the association with lower BMI was replicated in an Israeli sample, 22 several studies failed to confirm this. [23][24][25] Moreover, a study in American participants even showed that minor allele carriers had a greater fat body mass. 26 In a follow-up of the UK study, Gaunt et al 27 systematically sequenced all (un)translated exons and intron/exon boundaries of IGF2 and showed that three (6815A4T and 1156T4C in the 5 0 region, and 820G4A (ApaI)) out of eleven SNPs identified were independently associated with BMI.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Parent-of-origin specific linkage and association of the IGF2 gene region with birth weight and adult metabolic risk factors

et al. 2009

View full text Add to dashboard Cite

Objective: The maternally imprinted insulin-like growth factor 2 (IGF2) gene is an important fetal growth factor and is also suggested to have postnatal metabolic effects. In this study, we examined whether common polymorphisms in IGF2 (6815_6819delAGGGC, 1156T4C and 820G4A (ApaI)) and a microsatellite marker in the close vicinity of IGF2 were linked to or associated with birth weight and adult metabolic risk factors. Design and participants: Polymorphisms were genotyped in 199 monozygotic complete twin pairs, 109 dizygotic complete twin pairs, 15 single twins, 231 mothers and 228 fathers recruited from the East Flanders Prospective Twin Survey. Conventional and parent-of-origin specific linkage and association analyses were carried out with birth weight, adult body height and parameters quantifying obesity, insulin sensitivity and dyslipidaemia measured at adult age (mean age 25 years). Results: In the parent-of-origin specific association analysis, in which only the paternally inherited allele was incorporated, the 1156T4C SNP (single nucleotide polymorphism) showed significant association with IGF-binding protein 1 (IGFBP1) levels (T and C (mean (95% CI)): 13.2 (12.1-14.3) and 16.2 (14.6-18.0) ng ml À1 , P ¼ 0.002). No linkage was observed in either the conventional or in the parent-of-origin specific linkage analysis. Conclusion: This study suggests that paternally inherited alleles of a common polymorphism in the IGF2 gene affect IGFBP1 levels.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Parent-of-origin specific linkage and association of the IGF2 gene region with birth weight and adult metabolic risk factors

et al. 2009

View full text Add to dashboard Cite

show abstract

“…A distribuição da frequência genotípica teve comportamento semelhante aos estudos prévios (SAYER et al, 2002;SCHRAGER et al, 2004;GOMES et al, 2005), porém, diferindo dos outros grupos (GG e AA), a maior distribuição da frequência alélica do polimorfismo ApaI do gene IGF-2 foi encontrado com genótipos GA.…”

Section: Discussionunclassified

“…Já as mulheres AA apresentaram menor quantidade de massa livre de gordura e de força quando comparadas às mulheres GG. No estudo de Gomes et al (2005), a comparação das médias da massa corporal ao nascimento apresentou diferenças estatisticamente significantes entre A/A e G/G, sendo os portadores do genótipo G/G em média 0,639 kg mais pesados.…”

Section: Discussionunclassified

Associação do polimorfismo ApaI do gene IGF-2 com a força e a massa muscular em idosas brasileiras

et al. 2013

View full text Add to dashboard Cite

A sarcopenia diminui a capacidade funcional do idoso. O gene candidato Fator de Crescimento semelhante à Insulina-2 (IGF-2) tem influência na sarcopenia. Este estudo objetivou investigar a associação entre o polimorfismo ApaI do gene IGF-2 e os fenótipos força e massa muscular. Participaram deste estudo 252 voluntárias (66,94 ± 5,59 anos), as quais tiveram a força muscular mensurada em aparelho isocinético, a composição corporal analisada pelo DEXA e o nível de atividade física determinado pelo IPAQ. O DNA foi extraído e genotipado para o polimorfismo ApaI do gene IGF-2. Foi utilizada uma Anova e uma Ancova para comparar as variáveis (p>0,05). Não houve diferença significante entre as variáveis: idade, massa corporal, estatura, IMC e o percentual de gordura nos três grupos genotípicos. A análise de covariância demonstrou que não ocorreram diferenças significantes entre os grupos com os fenótipos analisados. Portanto, não houve associações significativas entre o polimorfismo ApaI do IGF-2 com a força muscular isocinética e a massa livre de gordura. Palavras-chave:Receptor IGF Tipo 2. Força Muscular. Idoso.

show abstract

A systematic analysis of disease-associated variants in the 3′ regulatory regions of human protein-coding genes II: the importance of mRNA secondary structure in assessing the functionality of 3′ UTR variants

2006

View full text Add to dashboard Cite

In an attempt both to catalogue 3' regulatory region (3' RR)-mediated disease and to improve our understanding of the structure and function of the 3' RR, we have performed a systematic analysis of disease-associated variants in the 3' RRs of human protein-coding genes. We have previously analysed the variants that have occurred in two specific domains/motifs of the 3' untranslated region (3' UTR) as well as in the 3' flanking region. Here we have focused upon 83 known variants within the upstream sequence (USS; between the translational termination codon and the upstream core polyadenylation signal sequence) of the 3' UTR. To place these variants in their proper context, we first performed a comprehensive survey of known cis-regulatory elements within the USS and the mechanisms by which they effect post-transcriptional gene regulation. Although this survey supports the view that RNA regulatory elements function within the context of specific secondary structures, there are no general rules governing how secondary structure might exert its influence. We have therefore addressed this question by systematically evaluating both functional and non-functional (based upon in vitro reporter gene and/or electrophoretic mobility shift assay data) USS variant-containing sequences against known cis-regulatory motifs within the context of predicted RNA secondary structures. This has allowed us not only to establish a reliable and objective means to perform secondary structure prediction but also to identify consistent patterns of secondary structural change that could potentiate the discrimination of functional USS variants from their non-functional counterparts. The resulting rules were then used to infer potential functionality in the case of some of the remaining functionally uncharacterized USS variants, from their predicted secondary structures. This not only led us to identify further patterns of secondary structural change but also several potential novel cis-regulatory motifs within the 3' UTRs studied.

show abstract

Association between birth weight, body mass index and IGF2/ApaI polymorphism

Cited by 35 publications

References 11 publications

Parent-of-origin specific linkage and association of the IGF2 gene region with birth weight and adult metabolic risk factors

Parent-of-origin specific linkage and association of the IGF2 gene region with birth weight and adult metabolic risk factors

Associação do polimorfismo ApaI do gene IGF-2 com a força e a massa muscular em idosas brasileiras

A systematic analysis of disease-associated variants in the 3′ regulatory regions of human protein-coding genes II: the importance of mRNA secondary structure in assessing the functionality of 3′ UTR variants

Contact Info

Product

Resources

About