Association between blood eosinophil count and bacterial infection and clinical outcomes in patients with severe exacerbations of chronic obstructive pulmonary disease

Wang, Fei; Yang, Luoman; Wang, Meng; He, Bei

doi:10.1097/cm9.0000000000001690

Chinese Medical Journal

2021

DOI: 10.1097/cm9.0000000000001690

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Association between blood eosinophil count and bacterial infection and clinical outcomes in patients with severe exacerbations of chronic obstructive pulmonary disease

Fei Wang

Luoman Yang

Meng Wang

et al.

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Cited by 4 publications

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“…It has been reported by a cohort of 6163 healthy people in China that, blood eosinophil counts were lower in patients with SVDD than in those with VDD, 25-hydroxyvitamin D insufficiency, and normal 25-hydroxyvitamin D levels. 27 This was consistent with our observation, but the reasons were not clear currently. Active vitamin D has been reported to prolong human eosinophil survival by upregulating C-X-C chemokine receptor type 4 expression.…”

supporting

confidence: 86%

Association of Severe Vitamin D Deficiency with Hospitalization in the Previous Year in Hospitalized Exacerbated COPD Patients

Li,

Liu,

Wang

et al. 2024

COPD

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supporting

confidence: 86%

Association of Severe Vitamin D Deficiency with Hospitalization in the Previous Year in Hospitalized Exacerbated COPD Patients

Li,

Liu,

Wang

et al. 2024

COPD

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The association between blood eosinophils and clinical outcome of acute exacerbations of chronic obstructive pulmonary disease: A systematic review and meta-analysis

Liu,

Xie,

Huang

et al. 2024

Respiratory Medicine

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Impact of blood eosinophil count on clinical outcomes in hospitalized Syrian patients with COPD exacerbation

Albuaini,

Najjar,

Tulaiba

et al. 2024

J Int Med Res

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Objective In this multicenter retrospective study, we evaluated the prognostic role of blood eosinophil count on clinical outcomes in hospitalized patients with exacerbations of chronic obstructive pulmonary disease (COPD). Methods We included patients aged 20 to 90 years with a COPD diagnosis. Patients were divided into groups with blood eosinophil count ≤300 or >300 cells/μL and then further classified into 1–99, 100–300, or >300 cells/μL. We compared sociodemographic features and clinical outcomes between groups and identified risk factors associated with mortality in hospitalized patients with COPD and blood eosinophil count ≤300 cells/μL. Results In total, 217 patients were included (82% men, average age 64.3±10.3 years). Patients with eosinophil counts ≤300 cells/μL had significantly longer hospital stays, more admissions to the intensive care unit (22.2% vs. 4.3%), and more frequent mechanical ventilation (21.6% vs. 4.3%) than those with eosinophil counts >300 cells/μL. Mortality only occurred in the group with ≤300 cells/μL; patients with COPD who had eosinophil counts >300 cells/μL had significantly better survival rates (17.0% vs. 0%). Conclusion High blood eosinophil counts at admission were associated with improved short-term outcomes. Our findings reveal the importance of considering eosinophil counts in clinical decision-making to manage hospitalized patients with COPD.

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Association between blood eosinophil count and bacterial infection and clinical outcomes in patients with severe exacerbations of chronic obstructive pulmonary disease

Cited by 4 publications

References 6 publications

Association of Severe Vitamin D Deficiency with Hospitalization in the Previous Year in Hospitalized Exacerbated COPD Patients

Association of Severe Vitamin D Deficiency with Hospitalization in the Previous Year in Hospitalized Exacerbated COPD Patients

The association between blood eosinophils and clinical outcome of acute exacerbations of chronic obstructive pulmonary disease: A systematic review and meta-analysis

Impact of blood eosinophil count on clinical outcomes in hospitalized Syrian patients with COPD exacerbation

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