Association between blood ethylene oxide levels and the prevalence of hypertension

Wu, Ningtao; Cao, Wenya; Wang, Yuxing; Liu, Xiaoqing

doi:10.1007/s11356-022-21130-z

Cited by 21 publications

(10 citation statements)

References 18 publications

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“…Nevertheless, data on EO exposure in the general population remains sparse. Several cross-sectional studies based on NHANES demonstrated that high EO levels were positively associated with diabetes, hypertension, and lipid pro les in adults [12,14,16]. Our ndings appear to be supported by above epidemiological studies, because NAFLD (hepatic presentation of metabolic syndrome) has a high correlation of metabolic comorbidities.…”

Section: Discussionsupporting

confidence: 81%

Association of ethylene oxide with nonalcoholic fatty liver disease among adult participants

Yan,

Zhen

2023

Preprint

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Background: Growing evidence suggest that ethylene oxide (EO) may have deleterious effects on health conditions, but the relationship between EO and adulthood nonalcoholic fatty liver disease (NAFLD) remains vague. Our objective is to evaluate whether EO exposure would influence the risk of NAFLD in a nationally cross-sectional study. Method: In this cross-sectional study, We analyzed 2709 participants from the National Health and Nutrition Examination Survey (NHANES) 2015-2018. Blood concentrations of EO were measured using high-performance liquid chromatography coupled with tandem mass spectrometry. Results: Hepatic steatosis index (HSI) were applied to define NAFLD. General linear and logistic regression models were adopted to investigate the relationship of Hemoglobin adducts of EO (HbEO) exposure with inflammation, HSI and NAFLD, respectively. Mediation analysis was adopted to further test the effect of inflammatory markers on the association between EO levels and NAFLD risk. General linear regression models showed that increased quartiles of HbEO were positively associated with hs-CRP (high-sensitivity C-reactive protein) (β: 0.113, 95% CI: 0.068-0.157), WBC (white blood cell) (β: 0.458, 95% CI: 0.358-0.559), Neutrophil (β: 0.295, 95% CI: 0.228-0.362), Lymphocyte (β: 0.128, 95% CI: 0.069-0.187), and HSI (β: 0.122, 95% CI: 0.017-0.228), after adjustment for age, gender, race/ethnicity, education, income, smoking status, drinking status, BMI, CVD, hypertension, diabetes, and TC. In logistic regression models, HbEO in the highest quartile was associated with the increased risk of NAFLD than those in the lowest quartile (OR: 2.23, 95% CI: 1.43-3.48, P-trend = 0.01). In addition, The mediation analysis manifested that the inflammatory markers partially mediated the HbEO-NAFLD associations (hs-CRP: 6.5%, WBC: 8.7%, and Neutrophil: 9.6%). Conclusions: The significant association between EO and NAFLD among US adults, and the underlying mechanisms were required to be identify in the future study.

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Section: Discussionsupporting

confidence: 81%

Association of ethylene oxide with nonalcoholic fatty liver disease among adult participants

Yan,

Zhen

2023

Preprint

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“…Community exposure to EtO represents a small subsample of relevant articles ( n = 5) (Table 4). Community level exposure was determined by residential proximity to a known EtO‐emitting facility or the presence of high blood levels of EtO (as collected by the CDC NHANES study) (Bulka et al., 2016; Chen, 2018; Guo et al., 2021; Jain, 2020; Wu et al., 2022). None of the included articles described symptoms of chronic low‐intensity EtO exposure experienced by community members.…”

Section: Resultsmentioning

confidence: 99%

“…None of the included articles described symptoms of chronic low‐intensity EtO exposure experienced by community members. Instead, multiple studies showed an association between community EtO exposure and significantly higher levels of breast cancer, lymphoma (specifically diffuse large B‐cell lymphoma), diabetes mellitus, and hypertension, even after controlling for known covariates (Bulka et al., 2016; Chen, 2018; Guo et al., 2021; Wu et al., 2022). One author did not find a significant association between EtO blood levels and cancer, but the study had noted limitations.…”

Section: Resultsmentioning

confidence: 99%

“…The results of this review suggest that EtO acts as a carcinogen, neurotoxin, and respiratory irritant at chronic low-intensity exposure levels. While symptoms can be reversible if the exposure is removed, prolonged EtO exposure is associated with the development of chronic and sometimes life-threatening conditions such as cancer, diabetes, and hypertension (Bulka et al, 2016;Chen, 2018;Guo et al, 2021;Wu et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

“…The results of this review suggest that EtO acts as a carcinogen, neurotoxin, and respiratory irritant at chronic low‐intensity exposure levels. While symptoms can be reversible if the exposure is removed, prolonged EtO exposure is associated with the development of chronic and sometimes life‐threatening conditions such as cancer, diabetes, and hypertension (Bulka et al., 2016; Chen, 2018; Guo et al., 2021; Wu et al., 2022). Adverse reproductive outcomes and diminished cognitive ability were also associated with prolonged exposure (Estrin et al., 1990; Gresie‐Brusin et al., 2007; Klees et al., 1990; Neghab et al., 2012; Patch & Hartlage, 2001; Rowland et al., 1996).…”

Section: Discussionmentioning

confidence: 99%

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Integrative literature review: Ethylene oxide exposure signs and symptoms

O'Kelley,

Swanson,

Bishop‐Royse

2023

Public Health Nursing

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BackgroundAlthough ethylene oxide (EtO) gas is designated as a human carcinogen, extant literature reports mixed findings on the health effects of exposure. The disparate findings may reflect industry bias as many studies were funded by a large chemical industry lobby.ObjectiveTo conduct an integrative review of studies free from industry bias to facilitate compilation of a comprehensive list of reported signs and symptoms of EtO exposure.MethodsWe reviewed 1887 papers of which 42 articles met inclusion criteria. The authors conducted this review in accordance with PRISMA guidelines. The presence of bias was assessed using Joanna Briggs Institute checklists.ResultsNon‐industry biased literature confirmed serious adverse health effects associated with EtO exposure at the occupational, hospital, and community level. EtO represents a carcinogen, neurotoxin, and respiratory irritant.ConclusionAfter removal of industry‐biased studies, EtO was unequivocally found to pose a threat to human health. There remains a gap in the number of studies examining community‐level exposure, which is essential to understanding the impact of EtO. Given that EtO‐emitting facilities are concentrated in diverse and disadvantaged communities, further study of EtO exposure health effects is warranted to inform public policy on toxic air emissions.

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Association between blood ethylene oxide levels and the prevalence of periodontitis: evidence from NHANES 2013–2014

Xue,

Tang,

Ren

et al. 2024

Clin Oral Invest

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Association between blood ethylene oxide levels and the prevalence of hypertension

Cited by 21 publications

References 18 publications

Association of ethylene oxide with nonalcoholic fatty liver disease among adult participants

Association of ethylene oxide with nonalcoholic fatty liver disease among adult participants

Integrative literature review: Ethylene oxide exposure signs and symptoms

Association between blood ethylene oxide levels and the prevalence of periodontitis: evidence from NHANES 2013–2014

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