Association between blood group and susceptibility to malaria and its effects on platelets, TLC, and Hb

Burhan, Hira; Hasan, Askari Syed; Mansur-Ul-Haque, Syed; Zaidi, Ghazanfar; Shaikh, Taha Gul; Zia, Aisha

doi:10.3855/jidc.6828

Cited by 4 publications

(5 citation statements)

References 10 publications

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“…According to the current study, no significant association was found (p = 0.319) between the blood group and thrombocytopenia, and all ABO blood groups showed similar falls in platelet levels, suggesting that thrombocytopenia was not affected by the ABO blood groups. Studies from India, 59 and Pakistan 60 showed similar findings.…”

Section: Discussionsupporting

confidence: 62%

“… 73 This could be a result of the sequestration of leukocytes, accelerated destruction, or decreased production. 74 The highest number of leukopenia was observed among blood group A (39.5%), followed by blood group O study participants (25.9%), in contrast with the studies conducted in India 59 and Pakistan 60 which were higher in B and AB blood groups, respectively. This discrepancy in results across different studies might be due to the methods they used for the determination of WBC counts and statistical tests that assume Gaussian distributions of data.…”

Section: Discussionmentioning

confidence: 79%

“… 67 The highest number of leukocytosis was detected in blood group B (33.3%), similar to a study conducted in Pakistan. 60 This might be attributed to the increased production of leukocytes at the onset of an infection to engulf the invading parasite. 77 The ABO blood group and WBC alterations among malaria-infected patients did not have a statistically significant correlation.…”

Section: Discussionmentioning

confidence: 99%

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Hematological Abnormalities Among Malaria Infected Adult Patients in Association with ABO Blood Groups at Jinella Health Center, Harar, Eastern Ethiopia

Asmerom,

Gemechu,

Sileshi

et al. 2023

JBM

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Background Hematological abnormalities are a common complication of malaria infection. However, there is a paucity of evidence regarding it among malaria-infected adult patients in association with the ABO blood group in Ethiopia, particularly in the Harari Region. Therefore, this study aimed to assess the hematological abnormalities among malaria-infected adult patients in association with ABO blood groups at Jinella Health Center, Harar, Eastern Ethiopia. Methods An institutional-based cross-sectional study was conducted from July 10, 2022, to January 10, 2023. Four milliliters of venous blood were collected from each study participant. Drops of blood were used for blood film preparation. ABO blood group was determined by agglutination test using monoclonal anti-sera (Agape Diagnostics Ltd., India). A complete blood count was done using the DxH 800 (Beckman Coulter, Inc, Miami, FL) hematology analyzer. The data were analyzed using SPSS version 26. Bivariable and multivariable logistic regression models were fitted. The level of significance was declared at a p-value of <0.05. Results The study revealed that 47.2% (95% CI: 41.0 53.6) of the participants were anemic. Being female (AOR = 3.18, 95% CI = 1.67, 6.04), having the A blood group (AOR = 2.75, CI = 1.20, 6.31), and being infected with P. falciparum (AOR = 2.64, CI = 1.26, 5.53) were all significantly associated with malaria anemia. The overall prevalence of thrombocytopenia was also 67.7% (95% CI: 61.7–73.4%). It was significantly associated with P. falciparum infection (AOR = 8.03, CI = 3.53, 18.25) and high parasitemia levels (AOR = 4.40, CI = 1.57, 12.32). Conclusion Patients with malaria who belonged to the “A” blood group in the study area had anemia as a serious health problem. Hence, frequently checking for anemia in patients with malaria who have blood group “A” can help with early detection and better management of anemia.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

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Hematological Abnormalities Among Malaria Infected Adult Patients in Association with ABO Blood Groups at Jinella Health Center, Harar, Eastern Ethiopia

Asmerom,

Gemechu,

Sileshi

et al. 2023

JBM

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“…Blood group O susceptibility to anaemia may be attributable to the pathogenesis of malaria, gender or other unknown causes. Nevertheless, our study failed to establish the link between the ABO blood group among children with iron or noniron-containing MNP and anaemia, as postulated in other findings in India [ 68 ] and the case–control analysis in Pakistan [ 69 ].…”

Section: Discussioncontrasting

confidence: 61%

Effect of iron fortification on anaemia and risk of malaria among Ghanaian pre-school children with haemoglobinopathies and different ABO blood groups

et al. 2023

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Background Haemoglobinopathies such as sickle cell disorder and glucose-6-phosphate dehydrogenase (G6PD) deficiency as well as differences in ABO blood groups have been shown to influence the risk of malaria and/or anaemia in malaria-endemic areas. This study assessed the effect of adding MNP containing iron to home-made weaning meals on anaemia and the risk of malaria in Ghanaian pre-school children with haemoglobinopathies and different ABO blood groups. Methods This study was a double-blind, randomly clustered trial conducted within six months among infants and young children aged 6 to 35 months in rural Ghana (775 clusters, n = 860). Participants were randomly selected into clusters to receive daily semiliquid home-prepared meals mixed with either micronutrient powder without iron (noniron group) or with iron (iron group; 12.5 mg of iron daily) for 5 months. Malaria infection was detected by microscopy, blood haemoglobin (Hb) levels were measured with a HemoCue Hb analyzer, the reversed ABO blood grouping microtube assay was performed, and genotyping was performed by PCR–RFLP analysis. Results The prevalence of G6PD deficiency among the study participants was 11.2%. However, the prevalence of G6PD deficiency in hemizygous males (8.5%) was significantly higher than that in homozygous females (2.7%) (p = 0.005). The prevalence rates of sickle cell traits (HbAS and HbSC) and sickle cell disorder (HbSS) were 17.5% and 0.5%, respectively. Blood group O was dominant (41.4%), followed by blood group A (29.6%) and blood group B (23.3%), while blood group AB (5.7%) had the least frequency among the study participants. We observed that children on an iron supplement with HbAS had significantly moderate anaemia at the endline (EL) compared to the baseline level (BL) (p = 0.004). However, subjects with HbAS and HbAC and blood groups A and O in the iron group had a significantly increased number of malaria episodes at EL than at BL (p < 0.05). Furthermore, children in the iron group with HbSS (p < 0.001) and the noniron group with HbCC (p = 0.010) were significantly less likely to develop malaria. Conclusions Iron supplementation increased anaemia in children with HbAS genotypes and provided less protection against malaria in children with HbAC and AS and blood groups A and O. Trial registration clinicaltrials.gov Identifier: NCT01001871. Registered 27/10/2009. Registration number: https://clinicaltrials.gov/ct2/show/record/NCT01001871.

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“…It intended to search the association between blood group distribution and susceptibility to malaria and effects on platelets, (total leukocyte count) TLC, and (hemoglobin) Hb. It concluded that no significant association exists between blood groups and susceptibility to malaria or developing anemia or thrombocytopenia [65]. Shakeel et al conducted a study at Nishter Hospital, Multan and Shaikh Zayd Hospital, Rahimyar Khan found that there was no significant difference between blood group frequency and Rh with chronic viral hepatitis [66].…”

Section: B) Malaria and Hepatitismentioning

confidence: 99%

Prevalence Of Blood Groups And Association With Ailments In Pakistani Population: A Review of The Current Literature

et al. 2023

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The aim of this review is to report studies performed in Pakistan on the prevalence of blood groups among various sections of the population and their association with human diseases. Google Scholar was searched for the last 20 years based on MESH keywords mentioned below. The inclusion criteria were the studies published in the new millennium that reported either prevalence of blood groups or their association with diseases in the Pakistani population. There were 50 studies in Pakistan which fulfill the inclusion criteria. Among them, twenty- six were from Punjab, seven were from Khyber Pakhtunkhwa (KpK), six from Sindh, four from Kashmir, two from Northern areas, one from Baluchistan and 4 are review articles. This review concludes that blood group B is prevalent among Pakistani population followed by O, A and AB. Studies done in Azad Jammu Kashmir (AJK) and Gilgit- Baltistan reveal that B and A is prevalent in these areas respectively. AB is the least found group and Rh+ve is common among all studies. Moreover, this review also shows that blood groups act as a risk factor for many diseases. Therefore, Pakistani researchers are suggested to work on the genetic makeup of these blood groups to find out the cause of association with systemic ailments in the country.

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Association between blood group and susceptibility to malaria and its effects on platelets, TLC, and Hb

Cited by 4 publications

References 10 publications

Hematological Abnormalities Among Malaria Infected Adult Patients in Association with ABO Blood Groups at Jinella Health Center, Harar, Eastern Ethiopia

Hematological Abnormalities Among Malaria Infected Adult Patients in Association with ABO Blood Groups at Jinella Health Center, Harar, Eastern Ethiopia

Effect of iron fortification on anaemia and risk of malaria among Ghanaian pre-school children with haemoglobinopathies and different ABO blood groups

Prevalence Of Blood Groups And Association With Ailments In Pakistani Population: A Review of The Current Literature

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