Association between blood pressure and risk of cancer development: a systematic review and meta-analysis of observational studies

Seretis, Aristeidis; Cividini, Sofia; Tseretopoulou, Xanthippi; López, David S.; Ntzani, Evangelia; Tsilidis, Konstantinos K.

doi:10.1038/s41598-019-45014-4

Cited by 143 publications

(125 citation statements)

References 177 publications

(129 reference statements)

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“…Alcohol intake has been associated with higher estradiol levels and higher mammographic density [12], and both pre-and postmenopausal breast cancer risk [13,14]. Recent meta-analysis observed a positive association between hypertension and breast cancer risk [15,16]. Moreover, a new cohort study reported a positive association between hypertension and breast cancer mortality after adjustments [17], supporting hypertension as an independent risk factor linked to breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Exploring the effects of lifestyle on breast cancer risk, age at diagnosis, and survival: the EBBA-Life study

Lofterød

Frydenberg

Flote

et al. 2020

Breast Cancer Res Treat

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Purpose Whether an unfavorable lifestyle not only affects breast cancer risk, but also influences age at onset of breast cancer and survival, is under debate. Methods In a population-based cohort, the Energy Balance and Breast Cancer Aspects throughout life (EBBA-Life) study, a total of 17,145 women were included. During follow-up, 574 women developed invasive breast cancer. Breast cancer cases were followed for an additional 9.1 years. Detailed medical records were obtained. Cox's proportional hazard regression models were used to study the association between pre-diagnostic lifestyle factors (weight, physical activity, alcohol use, smoking, and hypertension), breast cancer risk, age at diagnosis, and survival. Results At study entry, 34.3% of the participating women were overweight and 30.7% were physically inactive. Mean age at breast cancer diagnosis was 58.0 years, and 78.9% of the tumors were estrogen receptor positive. Among menopausal women who did not use hormone therapy and had an unfavorable lifestyle (3-5 unfavorable factors), compared with women who had a favorable lifestyle, we observed a twofold higher risk for postmenopausal breast cancer (hazard ratio [HR] 2.13, 95% confidence interval [CI] 1.23-3.69), and they were 3.4 years younger at diagnosis (64.8 versus 68.2 years, P = 0.032). Breast cancer patients with an unfavorable lifestyle, compared with patients with a favorable lifestyle, had almost a two times higher overall mortality risk (HR 1.96, 95% CI 1.01-3.80). Conclusions Our study supports a healthy lifestyle improving breast cancer prevention, postponing onset of disease, and extending life expectancy among breast cancer patients.

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Section: Introductionmentioning

confidence: 99%

Exploring the effects of lifestyle on breast cancer risk, age at diagnosis, and survival: the EBBA-Life study

Lofterød

Frydenberg

Flote

et al. 2020

Breast Cancer Res Treat

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“…In addition, the results from other large prospective studies reported positive associations of hypertension with the risk of cancers in locations other than the kidney in men (oropharynx, colon, rectum and anus, lung with larynx and trachea, bladder, malignant melanoma and non-melanoma skin cancer) 9 . The meta-analysis of four prospective studies between hypertension and esophageal adenocarcinoma yielded a statistically significant positive association 10 . Most recently, Christakoudi et al reported that there was a positive correlation between blood pressure and risk of esophageal carcinoma and head and neck cancers in a prospective European study 11 .…”

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confidence: 98%

Hypertension is associated with oral, laryngeal, and esophageal cancer: a nationwide population-based study

Seo

Kim

Park

et al. 2020

Sci Rep

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Several studies have reported an association between hypertension and upper aerodigestive tract cancer, but no large-scale, population-based studies have been conducted to confirm this.The aim of this study was to explore the association between hypertension and risk of upper aerodigestive tract cancer in Koreans. Participants who underwent a national health screening examination from January 1 to December 31, 2009 (n = 9,746,606) were enrolled. We assessed the development of oral, laryngeal, or esophageal cancer until 2016 using records from the Korean Health Insurance claims database during the study period. During the seven-year follow-up period, 6,062, 2,658, and 4,752 subjects were newly diagnosed with oral, laryngeal, and esophageal cancer, respectively. Participants with metabolic syndrome had the highest risk of developing oral cancer (hazard ratio (HR) 1.09, 95% confidence interval (CI) 1.03-1.16), laryngeal cancer (HR 1.27, 95% CI 1.17-1.38), and esophageal cancer (HR 1.11, 95% CI 1.04-1.19). Hypertension was a remarkable risk factor for each cancer (HR 1.11, 95% CI 1.04-1.17 for oral cancer; HR 1.23, 95% CI 1.13-1.33 for laryngeal cancer; HR 1.25, 95% CI 1.18-1.33 for esophageal cancer) after adjusting for age and other variables including gender, smoking status, alcohol intake, exercise, body mass index, and diabetes. Patients with untreated hypertension were at highest risk of developing oral cancer (HR 1.15; 95% CI 1.05-1.26), laryngeal cancer (HR 1.25; 95% CI 1.09-1.44), and esophageal cancer (HR 1.47; 95% CI 1.33-1.63) after adjusting for confounders. Hypertension was associated with the risk of oral, laryngeal, and esophageal cancer, despite of the lack of detailed biochemical information including the cancer cell types (squamous cell carcinoma or adenocarcinoma), cancer stage, physical findings and other medical history. Further studies are warranted to determine the reasons for this association and to establish effective interventions in this vulnerable population. One million new cases of upper aerodigestive tract (UADT) cancers are diagnosed worldwide every year, and they are ranked among the top ten most common cancers. Malignant tumors of the oral cavity, oropharynx, larynx, and esophagus comprise almost (or more than) 90% of all cancers of the UADT 1. Most of these cancers are histologically squamous cell carcinoma. Although the UADT is not considered a vital organ, it is closely associated with quality of life as it relates to eating, breathing, and speaking. Malignancies of this organ are therefore highly

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“…It should be noted that in both the prior and the present investigations, 33 the age of patients at the time of diagnosis was markedly lower than that reported in the western countries, where it averages 70 years. 43,44 In addition to male sex and older age, family history of the disease, 45,46 diabetes, 47 hypertension, 48 inflammatory bowel disease, 49,50 smoking, 51 and alcohol abuse, 52 are often considered risk factors for colorectal cancer. In the population under study, the incidence of colorectal cancer was highest in subjects suffering from hypertension (33.33%) and diabetes (31.48%), reflecting the worldwide trends.…”

Section: Discussionmentioning

confidence: 99%

<p>Predictors of Survival Among Colorectal Cancer Patients in a Low Incidence Area</p>

Azzam¹,

AlRuthia²,

Alharbi³

et al. 2020

CMAR

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Background: Colorectal cancer is the third most common malignancy in Saudi Arabia. The best therapeutic regimen for colorectal cancer is a matter of ongoing debate and data on its treatment in Saudi Arabia are limited. Purpose: The objective of this study was to explore the predictors of survival and to compare the risk of mortality among colorectal cancer patients treated with different therapeutic modalities. Patients and Methods: The study utilized data from the electronic colorectal cancer registry of a university-affiliated tertiary care hospital. The Kaplan-Meier survival analysis was used to estimate the survival rates over 36 months of follow-up across rectal and colon cancer patients as well as different sociodemographic and medical characteristics. Bivariate and multiple Cox proportional-hazards regressions were conducted to estimate the risk of mortality among rectal and colon cancer patients undergoing different treatments. Results: The number of patients in the registry who were followed up for 36 months was 143 patients. The majority of patients had colon cancer (74.13%). Rectal cancer patients had generally better survival estimates compared to their colon cancer counterparts. Colon cancer patients treated with chemotherapy had a significantly lower risk of mortality controlling for the use of surgery, radiotherapy, and other variables including age, gender, stage of cancer, and family history of colorectal cancer (HR=0.33; P=0.03). Additionally, colon cancer patients with a family history of colorectal cancer had significantly higher risk of mortality (HR=3.40; P=0.02). Conclusion: The findings of this study highlight the value of chemotherapy in managing colon cancer patients.

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Association between blood pressure and risk of cancer development: a systematic review and meta-analysis of observational studies

Cited by 143 publications

References 177 publications

Exploring the effects of lifestyle on breast cancer risk, age at diagnosis, and survival: the EBBA-Life study

Exploring the effects of lifestyle on breast cancer risk, age at diagnosis, and survival: the EBBA-Life study

Hypertension is associated with oral, laryngeal, and esophageal cancer: a nationwide population-based study

<p>Predictors of Survival Among Colorectal Cancer Patients in a Low Incidence Area</p>

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