Association Between Body Composition and Pulmonary Function in Elderly People: The Korean Longitudinal Study on Health and Aging

Lim, Soo; Kwon, Sung-Youn; Yoon, Ji Won; Kim, So Yeon; Choi, Sung Hee; Park, Young Joo; Yoon, Ho Il; Chang, Yoon Seok; Lee, Jae Ho; Lee, Choon–Taek; Kim, Ki Woong; Park, Kyong Soo; Jang, Hak Chul

doi:10.1038/oby.2010.167

Cited by 48 publications

(33 citation statements)

References 41 publications

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“…Thirdly, the assessment values of DXA and anthropometric fat measurements were compared. Relative to anthropometric measures, DXA-derived measures are more accurate and could provide more information to understand the associations of regional fat with potential health risks [39,40]. The present study suggested that %TF and android/gynoid fat ratio were better predictors than WC in normal BMI women.…”

Section: Discussionmentioning

confidence: 62%

Central Fat Accumulation Associated with Metabolic Risks beyond Total Fat in Normal BMI Chinese Adults

Zhu²,

Zhao³

et al. 2014

Ann Nutr Metab

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Objective: To investigate the association of central fat with metabolic risks in normal BMI Chinese people. Methods: Normal BMI subjects (18.5 ≤ BMI < 24, n = 520) aged 18-82 years were included. Blood pressure, triglycerides, high-density lipoprotein cholesterol and fasting plasma glucose were collected as metabolic risk factors. Dual-energy X-ray absorptiometry was used to measure total and central fat. Central fat was indicated as percent trunk fat (%TF) and android/gynoid fat ratio. Multiple adjusted regression models were applied to investigate the association of total and central fat with metabolic risk factors. The assessment values of these fat measures were further compared by receiver-operating characteristic (ROC) curves. Results: Both total and central fat were correlated with metabolic risk factors. After adjusting for BMI, the significant association of percent body fat (%BF) with metabolic risks diminished, whereas %TF and android/gynoid fat ratio were still correlated. When BMI was replaced with %BF in the models, the results remained unchanged. ROC analysis showed the areas under the curve (AUCs) of total and central fat for at least two metabolic risk factors were comparable in men. However, in women, the AUCs of %TF and android/gynoid fat ratio were significantly greater than those of BMI, %BF and waist circumference. Conclusions: Central fat accumulation had a stronger association with metabolic risks than total fat in normal BMI Chinese adults, particularly in women. Central fat had more important implications in assessing ‘metabolically obese' individuals among normal BMI subjects.

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Section: Discussionmentioning

confidence: 62%

Central Fat Accumulation Associated with Metabolic Risks beyond Total Fat in Normal BMI Chinese Adults

Zhu²,

Zhao³

et al. 2014

Ann Nutr Metab

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“…CT can distinguish between visceral and subcutaneous fat, and has been useful in measuring fat or muscle distribution at specific regions [23], [24]. However, there are several limitations in the VAT quantification using CT scan.…”

Section: Discussionmentioning

confidence: 99%

Android Fat Depot Is More Closely Associated with Metabolic Syndrome than Abdominal Visceral Fat in Elderly People

et al. 2011

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BackgroundFat accumulation in android compartments may confer increased metabolic risk. The incremental utility of measuring regional fat deposition in association with metabolic syndrome (MS) has not been well described particularly in an elderly population.Methods and FindingsAs part of the Korean Longitudinal Study on Health and Aging, which is a community-based cohort study of people aged more than 65 years, subjects (287 male, 75.9±8.6 years and 278 female, 76.0±8.8 years) with regional body composition data using Dual energy X-ray absorptiometry for android/gynoid area, computed tomography for visceral/subcutaneous adipose tissue (VAT/SAT), and cardiometabolic markers including adiponectin and high-sensitivity CRP were enrolled. We investigated the relationship between regional body composition and MS in multivariate regression models. Mean VAT and SAT area was 131.4±65.5 cm2 and 126.9±55.2 cm2 in men (P = 0.045) and 120.0±46.7 cm2 and 211.8±65.9 cm2 in women (P<0.01). Mean android and gynoid fat amount was 1.8±0.8 kg and 2.5±0.8 kg in men and 2.0±0.6 kg and 3.3±0.8 kg in women, respectively (both P<0.01). VAT area and android fat amount was strongly correlated with most metabolic risk factors compared to SAT or gynoid fat. Furthermore, android fat amount was significantly associated with clustering of MS components after adjustment for multiple parameters including age, gender, adiponectin, hsCRP, a surrogate marker of insulin resistance, whole body fat mass and VAT area.ConclusionsOur findings are consistent with the hypothesized role of android fat as a pathogenic fat depot in the MS. Measurement of android fat may provide a more complete understanding of metabolic risk associated with variations in fat distribution.

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“…Studies in elderly people have shown that fat free mass, muscle in the trunk and low extremity are associated with respiratory function9, 10, 25 ) . In addition, it has been reported that sarcopenia, an age-related reduction in muscle mass47 ) , causes breathing muscle weakness.…”

Section: Discussionmentioning

confidence: 99%

“…Respiratory function also decreases with age21, 22 ) and it is postulated that this is related to respiratory function and muscle mass. However, although studies for patients with COPD have shown that systemic inflammation and skeletal muscle disorders are associated with reduced physical activity23, 24 ) , there are limited reported studies on the association between respiratory function and muscle mass in the working age population in the abscence of COPD25 ) .…”

Section: Introductionmentioning

confidence: 99%

The association between the body composition and lifestyle affecting pulmonary function in Japanese workers

et al. 2016

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[Purpose] The purpose of this study was to identify factors related to physical characteristics and lifestyle that affect pulmonary function. [Subjects and Methods] Ninety seven healthy male workers were recruited for this study, and basic information and details about lifestyle were collected. Body composition analyzer and visceral fat measuring device were conducted as measurements. Pulmonary function was measured using spirometer. A multiple stepwise linear regression analysis was performed with pulmonary function as the dependent variable. Variables with a significant association with pulmonary function on univariate analysis were imputed as independent variables. [Results] Height, fat free mass, upper extremity muscle mass, lower extremity muscle mass, and trunk muscle mass had significant positive correlations with FEV1 and FVC. Age, percentage of body fat, and visceral fat area were negatively correlated with FEV1 and FVC. Regarding the association between pulmonary function and lifestyle, a significant difference was found between the smoking index and the presence or absence of metabolic syndrome risk factors and both FEV1 and FVC. The multiple stepwise linear regression analysis with FEV1 as the dependent variable, adjusted for age and height, revealed that visceral fat area and fat free mass were significantly associated with FEV1. A similar analysis, FVC as the dependent variable identified visceral fat area. [Conclusion] FEV1 was independently associated with visceral fat area and fat free mass. FVC was independently associated with visceral fat area. These results may be valuable in preventing the decrease in respiratory function and, hence, in further preventing the onset of COPD.

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Association Between Body Composition and Pulmonary Function in Elderly People: The Korean Longitudinal Study on Health and Aging

Cited by 48 publications

References 41 publications

Central Fat Accumulation Associated with Metabolic Risks beyond Total Fat in Normal BMI Chinese Adults

Central Fat Accumulation Associated with Metabolic Risks beyond Total Fat in Normal BMI Chinese Adults

Android Fat Depot Is More Closely Associated with Metabolic Syndrome than Abdominal Visceral Fat in Elderly People

The association between the body composition and lifestyle affecting pulmonary function in Japanese workers

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