Association Between Body Composition and Development of Glucose Intolerance after Allogeneic Hematopoietic Cell Transplantation

Bhandari, Rusha; Teh, Jennifer Berano; He, Tianhui; Peng, Kelly; Iukuridze, Aleksi; Atencio, Liezl; Nakamura, Ryotaro; Mostoufi‐Moab, Sogol; McCormack, Shana E.; Lee, Kyuwan; Wong, F. Lennie; Armenian, Saro H.

doi:10.1158/1055-9965.epi-21-1449

Cited by 7 publications

(7 citation statements)

References 36 publications

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“…However, in terms of body cell number (BCM), some studies have suggested that the agreement between BCM measurements and DEXA is better in HD patients [ 14 ], but the agreement between BCM measurements and DEXA is poor in renal transplant patients [ 15 ]. Some studies have also suggested that the accuracy of BIA in measuring bone mineral content in HD patients is poor [ 16 ]. The reason for this may be the differences in BIA instruments involved in the studies, and the type and status of patients are also different.…”

Section: Resultsmentioning

confidence: 99%

Application of Bioelectrical Impedance Analysis in Nutritional Management of Patients with Chronic Kidney Disease

Guo,

Zhang,

et al. 2023

Nutrients

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Body composition measurement plays an important role in the nutritional diagnosis and treatment of diseases. In the past 30 years, the detection of body composition based on bioelectrical impedance analysis (BIA) has been widely used and explored in a variety of diseases. With the development of technology, bioelectrical impedance analysis has gradually developed from single-frequency BIA (SF-BIA) to multi-frequency BIA (multi-frequency BIA, MF-BIA) and over a range of frequencies (bioimpedance spectroscopy, BIS). As the clinical significance of nutrition management in chronic kidney disease has gradually become prominent, body composition measurement by BIA has been favored by nephrologists and nutritionists. In the past 20 years, there have been many studies on the application of BIA in patients with CKD. This review describes and summarizes the latest research results of BIA in nutritional management of patients with CKD including pre-dialysis, hemodialysis, peritoneal dialysis and kidney transplantation, in order to provide reference for the application and research of BIA in nutritional management of chronic kidney disease in the future.

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Section: Resultsmentioning

confidence: 99%

Application of Bioelectrical Impedance Analysis in Nutritional Management of Patients with Chronic Kidney Disease

Guo,

Zhang,

et al. 2023

Nutrients

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“…Abnormal skeletal muscle was defined as having an abnormally low SMG, because the index represents a composite measure (quantity and quality) of skeletal muscle health, [29][30][31] including in patients undergoing HCT. 25 Individuals were considered to have abnormal visceral adipose tissue (VAT) according to sex-based VAT tertile cutoffs (.100 cm 2 [female]; .168 cm 2 [male]).…”

Section: Body Composition At Car T-cell Therapymentioning

confidence: 99%

“…Recent advances in software technology have facilitated the near real-time integration of body muscle and fat measurements into CT imaging obtained for standard clinical care, setting the stage for risk stratification for primary or secondary prevention. [22][23][24][25] The overall aims of this study were to describe the association between skeletal muscle measurements obtained from pretreatment CT images and postinfusion acute toxicities (eg, CRS, ICANS) as well as 1-year PFS and OS after CAR T-cell therapy, and to identify individuals at highest risk for worse outcomes after treatment.…”

Section: Introductionmentioning

confidence: 99%

Association Between Pretreatment Skeletal Muscle and Outcomes After CAR T-Cell Therapy

Lee

Iukuridze

et al. 2023

Journal of the National Comprehensive Cancer Network

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Background: The purpose of this study was to examine the association between baseline skeletal muscle measurements, acute toxicity (immune effector cell–associated neurotoxicity syndrome [ICANS], cytokine release syndrome), and treatment efficacy in patients undergoing CAR T-cell therapy for B-lineage lymphoma. Patients and Methods: Skeletal muscle measurements were obtained from automated CT measurements in 226 consecutive patients who received CAR T-cell therapy between 2015 and 2021. The Kaplan-Meier method was used to examine progression-free survival (PFS) and overall survival (OS) at 1-year. Multivariable regression was used to calculate the hazard ratio (HR) with 95% confidence intervals, adjusted for covariates. Results: The median age of the cohort was 63.1 years (range, 18.5–82.4 years), and most patients were male (66%) and had primary refractory disease (58%). Patients with abnormally low skeletal muscle at baseline were at greater risk of ICANS (HR, 1.74; 95% CI, 1.05–2.87) and had longer length of hospitalization (mean 27.7 vs 22.9 days; P<.05) compared with those with normal muscle mass. Abnormal skeletal muscle was independently associated with risk of disease progression (HR, 1.70; 95% CI, 1.11–2.57) and worse survival (HR, 2.44; 95% CI, 1.49–4.00) at 1 year compared with normal skeletal muscle. Individuals who had abnormal skeletal muscle and high lactate dehydrogenase (LDH) levels at baseline had poor 1-year PFS (17%) and OS (12%) compared with those with normal skeletal muscle and LDH levels (72% and 82%, respectively; P<.001). Patients who had abnormal skeletal muscle and LDH levels had a 5-fold risk (HR, 5.34; 95% CI, 2.97–9.62) of disease progression and a 10-fold risk (HR, 9.73; 95% CI, 4.81–19.70) of death (reference: normal skeletal muscle, normal LDH), independent of prior lines of therapy, extent of residual disease at time of CAR T-cell therapy, functional status, or product. Conclusions: This information can be used for risk stratification prior to CAR T-cell therapy or to implement prehabilitation and nutritional optimization before lymphodepletion as well as thereafter. These efforts will be complementary to ongoing efforts toward sustained efficacy after CAR T-cell therapy.

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“…However, in terms of body cell number (BCM), some studies have suggested that the agreement between BCM measurements and DEXA is better in HD patients [14], but the agreement between BCM measurements and DEXA is poor in renal transplant patients [15]. Some studies have also suggested that the accuracy of BIA in measuring bone mineral content in HD patients is poor, but more studies are needed to comprehensively evaluate [16].…”

Section: Compared With Other Body Composition Measurementmentioning

confidence: 99%

Application of bioelectrical impedance analysis in nutritional management of patients with chronic kidney disease

Guo,

Zhang,

et al. 2023

Preprint

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Body composition measurement plays an important auxiliary role in the nutritional assessment of diseases, nutritional diagnosis and the evaluation of the effect of nutritional therapy. There are many techniques and methods available for the measurement of body composition. Bioelectrical impedance analysis (BIA ) of body composition has been widely used and explored in many diseases in the past 30 years. Its main advantages are its non-invasiveness, non-radiation, economy, convenience and feasibility. With the development of bioelectrical impedance technology, bioelectrical impedance analysis has gradually developed from single-frequency BIA (SF-BIA) to dual-frequency BIA (DF-BIA). now devices are available that measure at multiple ﬁxed frequencies (multi-frequency BIA, MF-BIA) and over a range of frequencies (bioimpedance spectroscopy, BIS). The clinical significance of nutrition management in chronic kidney disease has gradually become prominent. Bioelectrical impedance analysis of body composition is favored by nephrologists and nutritionists as an auxiliary method for nutrition diagnosis, treatment and monitoring. In the past 20 years, there have been many studies on body composition measurement by bioelectrical impedance analysis in the nutritional management of CKD patients. This article will summarize the recent research results of BIA of body composition method in the nutrition management of CKD patients in pre-dialysis, hemodialysis, peritoneal dialysis and kidney transplantation, in order to provide reference for the application and research of BIA method in the nutrition management of chronic kidney disease in the future.

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Association Between Body Composition and Development of Glucose Intolerance after Allogeneic Hematopoietic Cell Transplantation

Cited by 7 publications

References 36 publications

Application of Bioelectrical Impedance Analysis in Nutritional Management of Patients with Chronic Kidney Disease

Application of Bioelectrical Impedance Analysis in Nutritional Management of Patients with Chronic Kidney Disease

Association Between Pretreatment Skeletal Muscle and Outcomes After CAR T-Cell Therapy

Application of bioelectrical impedance analysis in nutritional management of patients with chronic kidney disease

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