Association between body composition and survival in head and neck cancer patients undergoing radiotherapy

Zhuang, Bing; Xiao, Shan; Zhang, Lichuan; Wang, Yujie; Zhang, Tong; Jin, Sanli; Huang, Zhou; Zhao, Dan; Gong, Liqing; Liu, Weixin; Xu, Xiaolong; Zheng, Bingna; Sun, Yan; Lü, Qian

doi:10.1002/hed.27065

Cited by 7 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Zhuang et al. discovered that skeletal muscle mass was an independent prognostic factor for OS in head and neck cancer patients 23 . Similarly, Sanchez et al.…”

Section: Discussionmentioning

confidence: 93%

“…9 Zhuang et al discovered that skeletal muscle mass was an independent prognostic factor for OS in head and neck cancer patients. 23 Similarly, Sanchez et al showed that body composition can be used as a novel prognostic factor with the potential to enhance bladder cancer patients' survival. 24 The findings of this research align with prior studies, indicating that SMD can serve as a standalone prognostic indicator for patients with MIBC.…”

Section: Discussionmentioning

confidence: 99%

“…discovered that skeletal muscle mass was an independent prognostic factor for OS in head and neck cancer patients. 23 Similarly, Sanchez et al. showed that body composition can be used as a novel prognostic factor with the potential to enhance bladder cancer patients' survival.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A novel nomogram based on body composition and nutritional indicators to predict the prognosis of patients with muscle‐invasive bladder cancer undergoing radical cystectomy

Zhong,

Pan,

et al. 2023

Cancer Medicine

View full text Add to dashboard Cite

ObjectiveTo investigate the prognostic significance of body composition and nutritional indicators in patients undergoing radical cystectomy with muscle‐invasive bladder cancer (MIBC) and to develop a novel nomogram that accurately predicts overall survival (OS).MethodsFrom December 2010 to December 2020, we retrospectively collected clinical and pathological data from 373 MIBC patients who underwent radical cystectomy at our hospital. Preoperative computed tomography (CT) images were used to measure the skeletal muscle index (SMI), subcutaneous adipose index (SAI), visceral adipose index (VAI), skeletal muscle density (SMD), subcutaneous adipose density (SAD), visceral adipose density (VAD), and visceral adipose to subcutaneous adipose area ratio (VSR). The clinicopathological characteristics were evaluated using LASSO regression and multivariate Cox regression, and a nomogram was constructed to predict 1‐, 3‐, and 5‐year overall survival. The concordance index (C‐index), time‐dependent receiver operating characteristic curves (t‐ROC), calibration curve, and decision curve analysis (DCA) were used to assess the discriminative ability, calibration, and clinical practicality of the nomogram.ResultsMultivariate analyses demonstrated that pT stage, lymph node status, LVI, SMD, and prognostic nutritional index (PNI) are independent prognostic factors for OS. Additionally, a nomogram was created. The nomogram's C‐index was 0.714 (95% CI: 0.695–0.733). The area under the t‐ROC curve of 1‐, 3‐, and 5‐year survival corresponding to the model was 0.726, 0.788, and 0.785, respectively. The calibration curve demonstrated excellent agreement between the predicted and observed outcomes. The DCA revealed that patients with MIBC could benefit from the nomogram.ConclusionBased on body composition and nutritional indicators, we developed a novel nomogram with excellent predictive accuracy and reliability for predicting the prognosis of MIBC patients undergoing RC.

show abstract

“…Zhuang et al. discovered that skeletal muscle mass was an independent prognostic factor for OS in head and neck cancer patients 23 . Similarly, Sanchez et al.…”

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A novel nomogram based on body composition and nutritional indicators to predict the prognosis of patients with muscle‐invasive bladder cancer undergoing radical cystectomy

Zhong,

Pan,

et al. 2023

Cancer Medicine

View full text Add to dashboard Cite

show abstract

Therapy of head and neck cancer in China: Introduction to the special issue

Guo

2022

Head & Neck

View full text Add to dashboard Cite

How do patients with head and neck cancer and low skeletal muscle mass experience cisplatin-based chemoradiotherapy? A qualitative study

Schaeffers,

van Beers,

Devriese

et al. 2024

Support Care Cancer

View full text Add to dashboard Cite

Background Patients with head and neck squamous cell carcinoma (HNSCC) face several physical, emotional, and psychological challenges throughout treatment. Cisplatin-based chemoradiotherapy (CRT) is an effective but toxic treatment, with an increased risk for toxicities in patients with low skeletal muscle mass (SMM). Consequently, these patients are anticipated to experience greater treatment-related difficulties. We aimed to explore the experiences of patients with HNSCC and low SMM regarding cisplatin-based CRT. Methods A descriptive qualitative study was conducted, interviewing seven patients 3 months after CRT using a topic guide. Thematic analysis of semi-structured interviews was conducted, to create a multi-dimensional understanding of patients’ experiences during and after cisplatin-based CRT. Results Prior to CRT themes included pre-treatment information, expectations towards treatment and trial, psychosocial circumstances, and supporting network. During CRT themes included toxicities, psychosocial impact, and supporting network. After CRT themes included reflection on period during CRT, psychosocial circumstances, informal support from networks and healthcare workers, and ongoing toxicities. Conclusion Most patients experience cisplatin-based CRT as a life-changing and distressing life event but cope through various strategies and supporting networks. Tailored counseling, ideally with on-demand consultations, is recommended. No differences were noted in patients’ perceptions of their cisplatin regimen.

show abstract

Association between body composition and survival in head and neck cancer patients undergoing radiotherapy

Cited by 7 publications

References 30 publications

A novel nomogram based on body composition and nutritional indicators to predict the prognosis of patients with muscle‐invasive bladder cancer undergoing radical cystectomy

A novel nomogram based on body composition and nutritional indicators to predict the prognosis of patients with muscle‐invasive bladder cancer undergoing radical cystectomy

Therapy of head and neck cancer in China: Introduction to the special issue

How do patients with head and neck cancer and low skeletal muscle mass experience cisplatin-based chemoradiotherapy? A qualitative study

Contact Info

Product

Resources

About