Association between body fat distribution and kidney stones: Evidence from a US population

Li, Guoxiang; Liang, Hu; Hao, Yunwu; Huang, Qingfeng; Shen, Xudong; Chen, Yang; Chen, Mingwei; Xi, Junhua; Hao, Zongyao

doi:10.3389/fendo.2022.1032323

Cited by 11 publications

(7 citation statements)

References 64 publications

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“…A recent study found that small height was associated with stone formation but not weight ( 28 ), which may be due to the limitations of BMI ( 29 ) and the presence of the obesity paradox ( 22 ). In order to better explore the relationship between obesity and kidney stones, some recent studies tend to use non-traditional obesity indicators as a measure of obesity, such as visceral adiposity index ( 30 ), android-to-gynoid ratio ( 31 ), and so on. To the best of our knowledge, this is the first cross-sectional human study to evaluate the association between WWI and kidney stones.…”

Section: Discussionmentioning

confidence: 99%

Study from the United States: increased prevalence of kidney stones in patients with high weight-adjusted waist index

Gui,

Yu,

Chen

et al. 2024

Front. Nutr.

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ObjectiveUsing data from NHANES 2007–2018, to examine the association between WWI (weight-adjusted waist index) index and prevalence of kidney stones.MethodsUsing multiple logistic regression analysis of the National Health and Nutrition Examination Survey (NHANES) 2007–2018, we evaluated the association between WWI index and the prevalence of kidney stones, followed by subgroup analysis of sensitive populations. Smooth curve fitting was used to determine whether there was a non-linear relationship between the WWI index and kidney stone prevalence, and threshold effect analysis was used to test this relationship.ResultsAmong 29,280 participants, 2,760 self-reported renal calculi. After adjustment for all confounders, there was a positive association between WWI and kidney stone prevalence (OR = 1.20, 95% CI: 1.12, 1.28), and this positive association was stronger with increasing WWI (and P = 0.01 for trend). Our results indicate a non-linear positive correlation between WWI index and kidney stones, with the saturation threshold effect analysis and the most important threshold value at 11.02. According to subgroup analysis, WWI showed the strongest association with kidney stone prevalence in participants aged 20–39 years, males, other US ethnic groups, and participants without hypertension and diabetes.ConclusionIncreased WWI is positively associated with increased incidence of kidney stones, and increased WWI is a high risk for kidney stones that should be treated with caution. This association should be more pronounced in people between the ages of 20 and 39 years, in men, in other US ethnic populations, and in participants who do not have hypertension or diabetes.

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Section: Discussionmentioning

confidence: 99%

Study from the United States: increased prevalence of kidney stones in patients with high weight-adjusted waist index

Gui,

Yu,

Chen

et al. 2024

Front. Nutr.

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“…A previous report indicated that the association between risk factors for uric acid stone formation and total body fat and trunk fat was stronger compared to body weight ( 27 ). The Android region, which includes the liver, pancreas, and kidneys, has been linked to an increased incidence of kidney stones, and an increase in the A/G ratio denotes an increase in the fat content of the Android region ( 21 ). On the other hand, Abufaraj et al.…”

Section: Discussionmentioning

confidence: 99%

“…Kidney stone occurrence (variable name: KIQ 026) was designed as an outcome variable. The participant was considered to have a kidney stone if he or she answered yes to the question, “Have you or the sample person (SP) ever had a kidney stone?” Previous research has established the reliability of self-reported kidney stone status ( 21 ).…”

Section: Methodsmentioning

confidence: 99%

Higher weight-adjusted waist index is associated with increased likelihood of kidney stones

Liu,

Ma,

Shi

2023

Front. Endocrinol.

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ObjectivesThe objective of this study was to evaluate the association between weight-adjusted waist index (WWI) and the prevalence of kidney stones among adults in the United States.MethodsThe cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning the years 2007-2018. A total of 31,344 participants were categorized into two groups: those with kidney stones and those without. WWI was determined by dividing waist circumference (cm) by the square root of body weight (kg). To examine the relationship between kidney stones and WWI, multivariate logistic regression models, smoothed curve fitting, and weighted generalized additive model (GAM) regression were employed. Subgroup analysis and interaction tests were conducted to explore the stability of this association across different groups.ResultsThe final analysis comprised a total of 31,344 participants, including 2,928 individuals who had a history of kidney stones. In the fully adjusted model, an increase in WWI exhibited a positive correlation with the prevalence of kidney stones (OR=1.34, 95% CI: 1.18-1.51). When WWI was converted into quartiles (Q1-Q4), participants in the highest quartile (Q4) had a 69% greater risk of developing kidney stones compared to those in the lowest quartile (Q1) (OR=1.69, 95% CI: 1.28-2.25). This positive association was particularly notable among non-diabetic patients.ConclusionOur study demonstrates a significant positive association between weight-adjusted waist index levels and an elevated prevalence of kidney stones among US adults. Furthermore, this research highlights the potential utility of weight-adjusted waist index in the prevention of kidney stones in the overall population. This relationship is limited and further research is needed to test this hypothesis.

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“…Lipid metabolism, including lipoprotein, TC, TG and other indicators, has always been a factor of concern in the risk of urinary calculi [5,[12][13][14] . In this single-center cross-sectional study involving 414 adults, we found that lipid metabolism was closely related to urinary calculi, and higher TyG index was independently related to the occurrence, load and recurrence of kidney calculi.…”

Section: Discussionmentioning

confidence: 99%

Clinical Lipid Metabolism Correlates with Urinary Calculus: TyG Index Has a Closer Correlation

Pan

Zhang

et al. 2023

Preprint

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Aims:We aimed to assess the association between lipid metabolism and kidney stones in Chinese adults. Methods:Data were obtained from the clinical data of our center in the past 3 years. The analysis included complete data on blood lipids and kidney stones in participants aged ≥18 years and non-stone controls. Weighted multivariate regression analysis and subgroup analysis were used to estimate the relationship between various lipid indexes and nephrolithiasis and burden and recurrence. Results: A total of 414 participants were included in the study, and their gender, age and other basic indicators showed no significant differences. In the adjusted logistic regression analysis results, the prevalence of kidney stones increased with the increase of triglyceride (TG), triglyceride-glucose (TyG) index and Apolipoprotein A-I (AIP) [TG: odds ratio (OR)= 2.14; 95% CI: 1.62-2.81; p < 0.001; TyG: OR=4.30; 95% CI: 2.75-6.72; p < 0.001; AIP: OR=10.12; 95% CI: 4.58-22.35; p < 0.001]. There was still a significant correlation with TyG index in the subgroup analysis of burden (OR=1.52; 95% CI: 1.04-2.22; p < 0.05) and recurrence (OR=2.77; 95% CI: 1.08-7.13; p < 0.05). Conclusions:Lipid metabolism is closely related to urinary system stones, and a higher TyG index is associated with an increased risk of kidney stone incidence, burden, and recurrence. We hypothesize that timely treatment and management of abnormal lipid metabolism may help improve or alleviate the occurrence, burden, and recurrence of urinary system stones. However, further large-scale prospective studies and basic experiments are still needed to clarify the exact causal relationship of this association.

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Association between body fat distribution and kidney stones: Evidence from a US population

Cited by 11 publications

References 64 publications

Study from the United States: increased prevalence of kidney stones in patients with high weight-adjusted waist index

Study from the United States: increased prevalence of kidney stones in patients with high weight-adjusted waist index

Higher weight-adjusted waist index is associated with increased likelihood of kidney stones

Clinical Lipid Metabolism Correlates with Urinary Calculus: TyG Index Has a Closer Correlation

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