Association between body mass index and suicide attempts in Chinese patients of a hospital in Shanxi district with first-episode drug-naïve major depressive disorder

Liu, Junjun; Jia, Fu‐Jun; Li, Chuanwei; Yuan, Hsinsung; Yang, Haidong; Yang, Ruchang; Yan, Yonghong; Zhang, Guangya; Zhang, Xiaobin; Ye, Gang; Li, Zhe; Du, Xiangdong; Zhang, Xiangyang

doi:10.1016/j.jad.2023.06.064

Cited by 11 publications

(11 citation statements)

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“…For sensitivity analysis, we converted BMI from a continuous variable to a categorical variable. Based on guidelines from the Working Group on Obesity in China (WGOC) 16 , participants were classified into BMI categories of underweight (< 18.5 kg/m 2 ), normal weight (18.5–23.9 kg/m 2 ), overweight (24–27.9 kg/m 2 ), or obesity (≥ 28 kg/m 2 ). Compared to those with normal weight, overweight males exhibited reduced odds of SA (OR = 0.38, 95% CI 0.22–0.64, P < 0.001), whereas underweight females showed increased odds of SA (OR = 7.85, 95% CI 1.47–41.84, P = 0.016).…”

Section: Resultsmentioning

confidence: 99%

“…In large Swedish cohort research, Batty et al 29 showed an increased risk of SA in underweight men, and they also found that low weight was inversely correlated with SA within the normal BMI range. Individuals with a low BMI are predisposed to diminished physical functioning, which in turn is associated with emotional distress and more severe depressive symptoms 16 . A study conducted in the United States found that among men with MDD, a lower BMI was correlated with increased depressive symptom severity 30 .…”

Section: Discussionmentioning

confidence: 99%

“…In addition, some objective indicators, such as body mass index (BMI), an indicator of an unhealthy lifestyle, nutrition, physical activity, an unbalanced intake of energy, and insulin resistance, have also been the focus of researchers 15 . Factors affecting BMI may also influence neurodevelopment and the neuroendocrine system, which can affect the risk of developing mental illness 16 . However, the relationship between BMI and adult SA in patients of different genders is still unclear, with controversial research results.…”

Section: Introductionmentioning

confidence: 99%

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Gender differences in the association between body mass index and recent suicide attempts in Chinese patients with first-episode drug-naïve major depressive disorder

Liu,

Li,

Jia

et al. 2023

Sci Rep

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Controversial evidence exists on the relationship between body mass index (BMI) and suicide attempts (SA) in patients with major depressive disorder (MDD). This cross-sectional study aimed to explore the association between BMI and SA in first-episode drug-naïve (FEDN) MDD patients in China. The study was conducted from 2016 to 2018 in Taiyuan, China. Univariate and multivariate logistic regression analyzed the BMI–SA association, with subgroup analysis for gender. Threshold effects were examined using two-piecewise regression. In males, BMI was significantly associated with SA (OR = 0.84, 95% CI 0.74–0.94, P = 0.003) after full adjustment, but not in females (OR = 0.97, 95% CI 0.89–1.06, P = 0.541). The interaction with gender was significant (P for interaction < 0.05). Smoothing plots revealed an L-shaped BMI–SA relationship in both genders, with BMI inflection points at 27.3 kg/m2 in males and 21.4 kg/m2 in females. Below the inflection points, BMI is negatively associated with SA in males (OR = 0.75, 95% CI 0.66–0.86, P < 0.001) and females (OR = 0.48, 95% CI 0.32–0.72, P < 0.001). Above the inflection points, no association existed for both genders (all P > 0.05). Results showed an L-shaped nonlinear BMI–SA relationship in FEDN MDD patients but differing BMI inflection points between genders, thus contributing to effective prevention programs for suicide.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gender differences in the association between body mass index and recent suicide attempts in Chinese patients with first-episode drug-naïve major depressive disorder

Liu,

Li,

Jia

et al. 2023

Sci Rep

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“…To the best of our knowledge, few studies have developed a prediction model to determine the probability of SA in patients with rst-episode drug-naïve (FEND) MDD, particularly within the Chinese population. Patients with FEND MDD offer a unique opportunity to study the connection between SA and associated risk factors in MDD patients without the confounding in uence of medications and lifestyle interventions, such as disease course and comorbid medical illness [19]. Therefore, the objective of this study was to construct and validate a novel nomogram combining evidence-based and statistically signi cant clinical features to predict the risk of SA in a relatively large sample size of patients with FEND MDD in China.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a nomogram for suicide attempts in patients with first-episode drug- naïve major depressive disorder

Liu,

Tong,

et al. 2024

Preprint

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Objective: The risk of suicide can be decreased by accurately identifying high-risk suicide groups and implementing the right interventions. The aim of this study was to develop a predictive nomogram for suicide attempts (SA) in patients with first-episode drug-naïve (FEDN) major depressive disorder (MDD). Methods: A cross-sectional investigation was conducted, enrolling 1,718 patients diagnosed with FEDN MDD who provided comprehensive clinical data between September 2016 and December 2018. Anthropometric and sociodemographic data were collected from the participants. The severity of depression and anxiety in all subjects was assessed using the 17-item Hamilton Depression Scale (HAMD-17) and the Hamilton Anxiety Scale (HAMA), respectively. Additionally, thyroid hormone levels, lipid profile parameters, and fasting blood glucose (FBG) were measured. The confirmation of SA history relied on an amalgamation of medical records, patient interviews, and family interviews. Random allocation assigned participants to either the training group (70%, n = 1,204) or the validation group (30%, n = 514). In the training group, LASSO analysis and multivariate regression were employed to identify the relevant variables associated with SA. Subsequently, a nomogram was developed based on the selected risk factors to predict the probability of SA within the training group. To assess the accuracy of the prediction, the area under the receiver operating characteristic curve (AUC) was utilized, and calibration plots were employed to evaluate calibration. Additionally, decision curve analysis (DCA) was performed to assess the precision of the prediction model. Finally, internal validation was carried out using the validation group. Results: We have successfully developed a readily applicable nomogram that utilizes HAMD, HAMA, thyroid stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), and systolic blood pressure (SBP) parameters to forecast the likelihood of SA in Chinese patients with FEDN MDD. In both our training and validation groups, the pooled area under the ROC for SA risk was determined to be 0.802 (95% CI: 0.771 to 0.832) and 0.821 (95% CI: 0.774 to 0.868), respectively. Calibration analysis demonstrated a favorable alignment between the predicted probabilities from the nomogram and the actual probabilities. Decision curve analysis confirmed the clinical utility of the nomogram. To facilitate the utilization of the nomogram by clinicians and researchers, an online version is available at https://doctorjunjunliu.shinyapps.io/dynnomapp/. Conclusions: We constructed and validated a nomogram capable of early identification of FEDN MDD patients with a high risk of SA, thereby contributing to the implementation of effective suicide prevention programs.

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“…[16][17][18] Body mass index (BMI), a standard that commonly used to measure the degree of obesity and health level of the human body, is related to endocrine imbalance, sleep quality, dietary structure, physical exercise habits, one recent study showed that lower BMI, especially in those with BMI below 22.1 kg/m 2 , is associated with a higher risk of recent suicide attempts (SA) in Chinese patients with first-episode drug-naïve (FEDN) of major depressive disorder (MDD). 19 Some other studies suggested that Individuals with MDD exhibited reduced total 24-h heart rate variability (HRV) and daytime HRV, as well as ascended levels of inflammatory markers of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α), and multivariate analyses revealed robust inverse associations of total 24-h HRV and daytime HRV with IL-6, that is, an attenuated daytime HRV may correlate with higher circulating levels of IL-6 in MDD patients. Furthermore, one study confirmed that erythrocyte linoleic acid (LA) was positively associated with higher appendicular lean mass (ALM/BMI), higher premeal heart rate variability, and better reported overall sleep quality.…”

Section: Introductionmentioning

confidence: 99%

Effect of Regular Aerobic Exercise on Cognitive Function, Depression Level and Regulative Role of Neurotrophic Factor: A Prospective Cohort Study in the Young and the Middle-Aged Sample

Kong,

Miu,

Yao

et al. 2024

RMHP

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Mild cognitive impairment (MCI) and depressive disorder (DD), which are associated with unhealthy lifestyles, are prevalent worldwide. This study aimed to investigate the effects of regular aerobic exercise on cognitive function, depression, and the regulatory role of neurotrophic growth factors for providing scientific basis in preventing MCI and DD in healthy individuals. Patients and Methods: Eighty members of the fitness center and 80 community residents were recruited, who were administered by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and the Patient Health Questionnaire (PHQ-9). Brain-derived neurotrophic factor (BDNF) and glial cell-line-derived neurotrophic factor (GDNF) in the peripheral blood were detected by enzyme-linked immunosorbent assay (ELISA). Results:The RBANS and other factor scores, except for visuospatial abilities, were higher and PHQ-9 scores were lower in the study group than in the control group. The concentrations of BDNF and GDNF in the study group were higher than those in the control group. RBANS and its factor scores positively and PHQ-9 negatively correlated with BDNF and GDNF levels. Finally, multiple regression analysis showed that BDNF, as a predictor of RBANS, could explain 59.90% of its variance and that GDNF was a predictor of PHQ-9 could explain 12.30% of the variance. Conclusion: Regular aerobic exercise can improve cognitive function and depressive symptoms by increasing the BDNF and GDNF levels.

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Association between body mass index and suicide attempts in Chinese patients of a hospital in Shanxi district with first-episode drug-naïve major depressive disorder

Cited by 11 publications

References 44 publications

Gender differences in the association between body mass index and recent suicide attempts in Chinese patients with first-episode drug-naïve major depressive disorder

Gender differences in the association between body mass index and recent suicide attempts in Chinese patients with first-episode drug-naïve major depressive disorder

Development and validation of a nomogram for suicide attempts in patients with first-episode drug- naïve major depressive disorder

Effect of Regular Aerobic Exercise on Cognitive Function, Depression Level and Regulative Role of Neurotrophic Factor: A Prospective Cohort Study in the Young and the Middle-Aged Sample

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