Association between body mass index and sperm quality and sperm DNA integrity. A large population study

Oliveira, J.B.A.; Petersen, Claudia G.; Mauri, A.L.; Vagnini, L.D.; Renzi, Adriana; Petersen, B.; Mattila, Mariana; Dieamant, Felipe; Baruffi, R.L.R.; Franco, J.G.

doi:10.1111/and.12889

Cited by 54 publications

(38 citation statements)

References 68 publications

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“…In addition, our study did not control for other variables such as obesity, smoking, or alcohol drinking. These variables may also affect sperm parameters (García-Ferreyra et al, 2015;Oliveira et al, 2018). More studies with greater numbers of normal fertile individuals must be performed to confirm the effects of aging on sperm concentration, total sperm count, sperm motility, and sperm DNA fragmentation.…”

Section: Discussionmentioning

confidence: 99%

The effects of aging on semen parameters and sperm DNA fragmentation

Pino¹,

Sanz²,

Valdés³

et al. 2020

JBRA Assisted Reproduction

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Introduction:This study aimed to look into possible correlations between male age and different sperm parameters derived from semen analysis and sperm deoxyribonucleic acid (DNA) fragmentation.Methods: This retrospective descriptive study included 2681 male patients who underwent semen analysis at Clínica Las Condes (CLC), Santiago, Chile, between January 2014 and May 2017; correlations between age and sperm parameters were analyzed.Results: Males above the age of 50 were significantly more likely to present anomalies in semen volume, sperm concentration, and sperm DNA fragmentation; males aged 41+ years were more likely to have lower sperm concentration levels; males aged 31+ years were more likely to have decreased sperm motility; when concentration was constant, more volume and motility anomalies were seen as age increased; when volume was kept constant, more motility and concentration anomalies were seen as age increased; and when motility was constant, normal semen volumes decreased as age increased.Conclusion: Our study showed that male age significantly affects sperm parameters that might have an impact on male fertility.

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Section: Discussionmentioning

confidence: 99%

The effects of aging on semen parameters and sperm DNA fragmentation

Pino¹,

Sanz²,

Valdés³

et al. 2020

JBRA Assisted Reproduction

View full text Add to dashboard Cite

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“…Various studies have been conducted linking several lifestyle factors/environmental exposures to elevated levels of SDF [78,94,[189][190][191][192][193][194][195][196][197][198]. These factors include (i) Physical agents such as radiation and heat; (ii) Chemical agents such as cigarette smoke, airborne pollutants, and chemotherapeutic drugs; and (iii) Biological factors including sexually transmitted infections, increasing male age, elevated body mass index (BMI) and medical conditions such as insulin dependent diabetes [78,94,[189][190][191][192][193][194][195][196][197][199][200][201]. Elevated OS levels is believed to be the main mechanism resulting in SDF with these exposures.…”

Section: High Risk Patientsmentioning

confidence: 99%

Sperm DNA Fragmentation: A New Guideline for Clinicians

Agarwal

Majzoub

Baskaran

et al. 2020

World J Mens Health

186

144

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Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases of spermatogenesis, which imparts compaction and protects the genetic content. Testicular (defective maturation and abortive apoptosis) and post-testicular (oxidative stress) mechanisms are implicated in the etiology of sperm DNA fragmentation (SDF), which affects both natural and assisted reproduction. Several clinical and environmental factors are known to negatively impact sperm DNA integrity. An increasing number of reports emphasizes the direct relationship between sperm DNA damage and male infertility. Currently, several assays are available to assess sperm DNA damage, however, routine assessment of SDF in clinical practice is not recommended by professional organizations. This article provides an overview of SDF types, origin and comparative analysis of various SDF assays while primarily focusing on the clinical indications of SDF testing. Importantly, we report four clinical cases where SDF testing had played a significant role in improving fertility outcome. In light of these clinical case reports and recent scientific evidence, this review provides expert recommendations on SDF testing and examines the advantages and drawbacks of the clinical utility of SDF testing using Strength-Weaknesses-Opportunities-Threats (SWOT) analysis.

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“…Several factors are known to be associated with both female and male fertility, including increased body weight [3][4][5]. For example, men who are overweight are more likely to have abnormal sperm characteristics, such as impairments inamong otherssperm concentration, progressive motility, and normal morphology [6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

The potential role of central obesity in male infertility: body mass index versus waist to hip ratio as they relate to selected semen parameters

et al. 2020

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Background: Little is known about the potential role of central obesity among men. Our first aim was to confirm what is already known from prior research, namely that both BMI and WHR are inversely associated with selected semen parameters. Our second aim was to examine the potential role of central obesity by assessing if there was a difference between BMI and WHR regarding their relationships to these selected semen parameters. Methods: In this cross-sectional study between January 2011 to January 2018, we analyzed semen samples from 1169 patients who visited an andrology clinic in Budapest for infertility reasons. Variables assessed were: body measurements (height, weight, waist circumference, and hip circumference), and the results of semen analysis (sperm concentration, total sperm count, progressive sperm motility, and normal sperm morphology). Results: The mean height and weight were 180.6 cm and 87.3 kg, respectivelythe mean BMI was 26.8. The mean waist and hip circumferences were 100.9 cm and 94.8 cm, respectivelythe mean waist to hip ratio was 0.94. The mean sperm concentration, total sperm count, and percents of progressive motility and normal morphology were 48.7 M/ml, 165 million, 21.2, and 4.8%, respectively. Both BMI and WHR were significant correlates in all semen parameter regression models. When comparing the parameter estimates for BMI with those for WHR for each semen parameter, the parameter estimate for WHR was significantly lower (indicating a stronger negative association) than that for BMI for progressive motility and total sperm count, but not for normal morphology or concentration. Conclusions: Our study is the first to examine, using a large patient sample, the potential role of central obesity by comparing the difference between BMI and WHR as they relate to selected semen parameters. Our findings indicate a potential role of central obesity for progressive motility and total sperm count, but not for normal morphology and concentration. Despite the limitations and the exploratory nature of this study, we can conclude that our results point to a potential role of central obesity in male infertility, but this finding should be confirmed and further explored in future research.

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Association between body mass index and sperm quality and sperm DNA integrity. A large population study

Cited by 54 publications

References 68 publications

The effects of aging on semen parameters and sperm DNA fragmentation

The effects of aging on semen parameters and sperm DNA fragmentation

Sperm DNA Fragmentation: A New Guideline for Clinicians

The potential role of central obesity in male infertility: body mass index versus waist to hip ratio as they relate to selected semen parameters

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