Association between body mass index and outcomes in Japanese living kidney transplant recipients: The role of sex differences

Abstract

Sex differences and interaction effects must be considered when evaluating the effects of pretransplant body mass index on post-transplant outcomes in Japanese patients undergoing living kidney transplant.

Diabetes mellitus after kidney transplantation in Japanese patients: The Japan Academic Consortium of Kidney Transplantation study

“…In addition, there were no interactions between obesity and the other identified risk factors (age, TAC trough and MMF). Thus, separate management would be required to prevent PTDM in obese patients, including pre‐ and post‐transplant weight control . Although our definition of obesity was the same as that in a European study, we identified a marked discrepancy in the definition between Japan and the USA .…”

“…Thus, separate management would be required to prevent PTDM in obese patients, including pre‐ and post‐transplant weight control . Although our definition of obesity was the same as that in a European study, we identified a marked discrepancy in the definition between Japan and the USA . Nevertheless, a relative higher BMI is considered to be an established risk factor, and this unique feature of obesity on PTDM development might be generalizable to KTRs in the USA …”

“…The JACK project is an ongoing multicenter, retrospective observational cohort study in Japan. The objectives and protocol of the JACK have been previously described in great detail . KTRs were excluded if they had diabetes (fasting PG level ≥126 mg/dL or 2‐h PG level ≥200 mg/dL during a 75‐g OGTT) at the time of KT or had ESRD caused by diabetic nephropathy.…”

Once‐daily vs twice‐daily tacrolimus for de novo living kidney transplantation patients including ABO/HLA compatible and incompatible: A randomized trial

“…We cannot exclude racial or ethnic influences on PK results. The distributions in CYP3A5 genotypes and body mass index are considerably different worldwide …”

“…The distributions in CYP3A5 genotypes and body mass index are considerably different worldwide. 32,33 This trial also involved an important discrepancy. Despite the propensity for an early higher BPAR rate, TAC-QD did not translate to increased graft failure or decreased eGFR as in past reports.…”