Association between Bone Mineral Density of Femoral Neck and Geriatric Nutritional Risk Index in Rheumatoid Arthritis Patients Treated with Biological Disease-Modifying Anti-Rheumatic Drugs

Tokumoto, Hiroto; Tominaga, Hiroyuki; Arishima, Yoshiya; Jokoji, Go; Akimoto, Masaki; Ohtsubo, Hideo; Taketomi, Eiji; Sunahara, Nobuhiko; Nagano, Satoshi; Ishidou, Yasuhiro; Komiya, Setsuro; Setoguchi, Takao

doi:10.3390/nu10020234

Cited by 24 publications

(14 citation statements)

References 41 publications

(55 reference statements)

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“…As a consequence, it has been proven that GNRI can be applied as a convenient and reliable indicator for the BMD conditions of patients with the above diseases. In addition, it has been shown that there is a dramatically inverse relationship between GNRI and BMD in rheumatoid arthritis patients. As the association is caused by protein that originates from animals and plants , it is crucial to guarantee the intake of enough protein from the diet.…”

Section: Discussionmentioning

confidence: 99%

Association between the Geriatric Nutritional Risk Index, bone mineral density and osteoporosis in type 2 diabetes patients

Wang

Zhang

2020

J of Diabetes Invest

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Aims/Introduction: Low bodyweight and hypoalbuminemia are independently associated with osteoporosis. In this study, the relationship among the Geriatric Nutritional Risk Index (GNRI), bone mineral density (BMD) and osteoporosis in type 2 diabetes mellitus patients was explored, and the GNRI predictive value was evaluated. Materials and Methods: We enrolled 225 men and 192 women with type 2 diabetes mellitus. Their general condition, and laboratory and BMD data were collected. Spearman's partial correlation analysis adjusting for age, body mass index and albumin was used for exploring the association among the GNRI, BMD and bone metabolism markers. Statistical analyses, including multivariate regression analysis and receiver operating characteristic curve analysis, were also applied in this study. Results: On Spearman's partial correlation analysis, GNRI was positively associated with BMD and albumin-corrected calcium (r = 0.145-0.561, P < 0.01). For the multivariate regression analysis, we observed that the GNRI was dramatically related to high total lumbar, total hip, femur neck BMD and osteoporosis (odds ratio 0.857 for men and 0.927 for women, all P < 0.05). The area under the receiver operating characteristic curve of the GNRI (0.876 for men and 0.704 for women, all P < 0.01) was the largest compared with that of albumin and body mass index in osteoporosis prediction. Conclusions: In this study, it was shown that the GNRI was positively correlated with BMD, and inversely correlated with osteoporosis in type 2 diabetes mellitus patients. In addition, compared with body mass index, albumin and age, the GNRI was a more powerful indicator for osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Association between the Geriatric Nutritional Risk Index, bone mineral density and osteoporosis in type 2 diabetes patients

Wang

Zhang

2020

J of Diabetes Invest

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“…Rheumatoid arthritis is a chronic representative autoimmune disease associated with inflammation and nutritional status . In our study, we assessed the ALB‐dNLR score, which was based on albumin and dNLR in RA patients.…”

Section: Discussionmentioning

confidence: 99%

“…16,18 Rheumatoid arthritis is a chronic representative autoimmune disease associated with inflammation and nutritional status. 19,20 In our study, we assessed the ALB-dNLR score, which was based on albumin and dNLR in RA patients. The results found that RA patients tend to have higher ALB-dNLR scores than OA patients or healthy controls.…”

Section: Discussionmentioning

confidence: 99%

The association between albumin‐dNLR score and disease activity in patients with rheumatoid arthritis

Chen

et al. 2018

Clinical Laboratory Analysis

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Background Recently, clinical studies have described an association between albumin and the derived neutrophil to lymphocyte ratio (dNLR) with several diseases. This study was aimed to investigate the albumin‐dNLR (ALB‐dNLR) score in rheumatoid arthritis (RA) patients and assess its relationship with clinical and laboratory parameters of RA. Methods We retrospectively enrolled 127 RA patients, 155 osteoarthritis (OA) patients, and 155 healthy controls. The ALB‐dNLR score was based on serum albumin level, neutrophil count, and white cell count. The Spearman's rank test was used to measure the correlations between ALB‐dNLR score and disease activity as well as laboratory indexes. Results The ALB‐dNLR score was significantly higher in RA patients than in OA patients (P < 0.001) and in healthy controls (P < 0.001). The proportion of higher ALB‐dNLR score has been raised along with increased disease activity (P < 0.001). The Spearman's rank test showed that ALB‐dNLR score was positively associated with DAS28 score, CRP, ESR, IgA, and platelet count. Moreover, the receiver operating characteristic (ROC) curve showed that the area under the curve (AUC) of ALB‐dNLR was 0.693 (95% CI: 0.631‐0.755), which was higher than that of albumin (AUC: 0.625, 95% CI: 0.559‐0.692) and dNLR (AUC: 0.680, 95% CI: 0.617‐0.743) alone. Conclusions The results demonstrate that the ALB‐dNLR score increased in RA patients. The ALB‐dNLR score may be a useful marker to estimate the disease activity of RA patients.

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“…The GNRI, which takes both serum albumin and BMI into account, has also been associated with BMD in several recent studies. In a study of 146 Japanese patients, Tokumoto et al reported that a low GNRI was a risk factor for lower BMD of the femoral neck in patients with rheumatoid arthritis [35]. In addition, Wang et al reported a positive relationship between GNRI and BMD in Chinese patients with type 2 diabetes mellitus in a study of 225 men and 192 women [36].…”

Section: Discussionmentioning

confidence: 99%

Association between Geriatric Nutrition Risk Index and Skeletal Muscle Mass Index with Bone Mineral Density in Post-Menopausal Women Who Have Undergone Total Thyroidectomy

Chiu

Chen

et al. 2020

Nutrients

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Background: Osteoporosis is highly prevalent in postmenopausal women and may result in fractures and disabilities. Total thyroidectomy has also been associated with loss of bone mass. The aim of this cross-sectional study was to evaluate associations among nutritional status, skeletal muscle index and markers of bone turnover to bone mineral density in postmenopausal women who had undergone total thyroidectomy. Methods: Fifty postmenopausal women who had undergone total thyroidectomy were included. Body composition was measured using dual-energy X-ray absorptiometry (DXA). The Geriatric Nutritional Risk Index (GNRI) was calculated using baseline body weight and serum albumin level. Skeletal muscle mass index was calculated as the appendicular skeletal muscle mass (ASM) divided by the height squared and assessed using DXA. Results. Multivariate stepwise linear regression analysis showed that a low GNRI was significantly associated with low lumbar spine bone mineral density (BMD) and T-score, and that a low ASM/height2 was significantly associated with low femoral neck BMD and T-score. A low vitamin D level was significantly associated with low femoral neck BMD and T-score and low total hip BMD and T-score. A high bone alkaline phosphatase (ALP) level was significantly associated with low femoral neck T-score and low total hip BMD and T-score. A low insulin-like growth factor-1 (IGF-1) was significantly associated with low total hip BMD and T-score. Conclusion: In the postmenopausal women who had undergone total thyroidectomy in this study, BMD was positively associated with GNRI, skeletal muscle mass index, and levels of vitamin D and serum IGF-1, and inversely associated with bone ALP level. Nutritional status, skeletal muscle mass index and bone turnover biomarkers can be used to early identify patients with a high risk of osteoporosis in this high-risk group.

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Association between Bone Mineral Density of Femoral Neck and Geriatric Nutritional Risk Index in Rheumatoid Arthritis Patients Treated with Biological Disease-Modifying Anti-Rheumatic Drugs

Cited by 24 publications

References 41 publications

Association between the Geriatric Nutritional Risk Index, bone mineral density and osteoporosis in type 2 diabetes patients

Association between the Geriatric Nutritional Risk Index, bone mineral density and osteoporosis in type 2 diabetes patients

The association between albumin‐dNLR score and disease activity in patients with rheumatoid arthritis

Association between Geriatric Nutrition Risk Index and Skeletal Muscle Mass Index with Bone Mineral Density in Post-Menopausal Women Who Have Undergone Total Thyroidectomy

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