Association between bone mineral density and lumbar disc degeneration

Salo, Sami; Leinonen, Ville; Rikkonen, Toni; Vainio, Pauli; Marttila, Jarkko; Honkanen, Risto; Tuppurainen, Marjo; Kröger, Heikki; Sirola, Joonas

doi:10.1016/j.maturitas.2014.09.003

Cited by 38 publications

(23 citation statements)

References 24 publications

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“…Pathophysiology of disc degeneration is not well understood and is thought to occur gradually with aging. Recently, a study in Finnish postmenopausal women showed that higher lumbar bone mineral density (BMD) and Z -score from T2-weighted magnetic resonance imaging (MRI) were associated with more severe lumbar disc degeneration at L1–L4 levels [ 3 ], and experimental animal models have found that osteoporosis could have a role in IDD progression [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Genetic Polymorphisms of Interleukin-1 Alpha and the Vitamin D Receptor in Mexican Mestizo Patients with Intervertebral Disc Degeneration

Serrano

Villareal

Aguilar‐Medina

et al. 2014

International Journal of Genomics

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Intervertebral disc degeneration (IDD) is the most common diagnosis in patients with back pain, a leading cause of musculoskeletal disability worldwide. Several conditions, such as occupational activities, gender, age, and obesity, have been associated with IDD. However, the development of this disease has strong genetic determinants. In this study, we explore the possible association between rs1800587 (c.-949C>T) of interleukin-1 alpha (IL1A) and rs2228570 (c.2T>V) and rs731236 (c.1056T>C) of vitamin D receptor (VDR) gene polymorphisms and the development of IDD in northwestern Mexican Mestizo population. Gene polymorphisms were analyzed by polymerase chain reaction followed by restriction fragment length polymorphism, in two groups matched by age and gender: patients with symptomatic lumbar IDD (n = 100) and subjects with normal lumbar-spine MRI-scans (n = 100). Distribution of the mutated alleles in patients and controls was 27.0% versus 28.0% (P = 0.455) for T of rs1800587 (IL1A); 53.0% versus 58.0% (P = 0.183) for V of rs2228570 (VDR); and 18.0% versus 21.0% (P = 0.262) for C of rs731236 (VDR). Our results showed no association between the studied polymorphisms and IDD in this population. This is the first report on the contribution of gene polymorphisms on IDD in a Mexican population.

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Section: Introductionmentioning

confidence: 99%

Genetic Polymorphisms of Interleukin-1 Alpha and the Vitamin D Receptor in Mexican Mestizo Patients with Intervertebral Disc Degeneration

Serrano

Villareal

Aguilar‐Medina

et al. 2014

International Journal of Genomics

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“…Many studies have demonstrated that OP is associated with a reduced risk of DD and herniation. [ 8 , 10 – 13 , 15 , 18 ] The relationship between delayed DH and OP can be explained by 2 pathophysiological pathways: the mechanical pathway and vascular pathway. [ 8 ] In the mechanical pathway, vertebral stiffness decreases because of low vertebral BMD, and the relative stress on the disc is reduced because of the shock-absorbing characteristics of the intervertebral disc (IVD).…”

Section: Discussionmentioning

confidence: 99%

Effect of bone mineral density on lumbar discs in young adults

Keser

Atici²,

Çelikoğlu³

et al. 2017

Medicine

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Bone mineral density (BMD) might be a risk factor for lumbar disc herniation (LDH) in young adults, but there is not enough data concerning this effect. Several studies have been performed on elderly and osteoporotic patients. Thus, we aimed to investigate the effect of BMD on the etiopathogenesis of LDH in young adults.One hundred patients (mean age: 38.45 ± 8.92 years; 50 men and 50 women) were enrolled this case–control study and classified into 2 groups, as follows. The case group (G-I) included 50 patients with symptomatic LDH who were hospitalized in the Physical Medicine and Rehabilitation Clinic, and the control group (G-II) included 50 patients with lower back pain but no finding of LDH detected using magnetic resonance imaging. Patients in the G-II were recruited among those admitted to the outpatient clinic at the time of the study, and whose age and sex were matched to those of the study group. Women in menopause were excluded from the study. BMD analysis by dual energy x-ray absorptiometry was performed in both groups.The mean values of the femur neck and lumbar spine BMD were 1.02 ± 0.13 and 1.19 ± 0.14 g/cm2, respectively. There was no statistically significant relationship between BMD and LDH in this population.This result may mean that in a normal range, BMD does not exert a compressive load on the lumbar discs in young adults and therefore may not lead to LDH by this mechanism and the load.

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“… 9–12 However, genetics and age are not modifiable factors. Identification of modifiable factors associated with lumbar intervertebral disc degeneration, including obesity, 13 14 smoking, 15 medical conditions such as diabetes and dyslipidaemia, 13 16 bone mineral density, 18 occupation 13 19 and sport, 13 19 20 is important in preventing intervertebral disc disorders. In the present study, lumbar intervertebral disc degeneration was greater in field firefighters than administrative firefighters, suggesting that mechanical loading accelerates lumbar intervertebral disc degeneration and that reducing the load may help prevent related disorders.…”

Section: Discussionmentioning

confidence: 99%

“…Older age is associated with an increased prevalence of lumbar intervertebral disc degeneration. 8 Genetic factors 9–12 and modifiable factors, such as obesity, 13 14 smoking, 15 diabetes, 16 atherosclerosis, 16 17 dyslipidaemia, 13 bone mineral density, 18 occupation 13 19 and sport, 13 19 20 are also associated with lumbar intervertebral disc degeneration.…”

Section: Introductionmentioning

confidence: 99%

Lumbar intervertebral disc degeneration and related factors in Korean firefighters

et al. 2016

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ObjectivesThe job of firefighting can cause lumbar burden and low back pain. This study aimed to identify the association between age and lumbar intervertebral disc degeneration and whether the association differs between field and administrative (non-field) firefighters.MethodsSubjects were selected using a stratified random sampling method. Firefighters were stratified by geographic area, gender, age and type of job. First, 25 fire stations were randomly sampled considering regional distribution. Then firefighters were stratified by gender, age and their job and randomly selected among the strata. A questionnaire survey and MRI scans were performed, and then four radiologists used Pfirrmann classification methods to determine the grade of lumbar intervertebral disc degeneration.ResultsPfirrmann grade increased with lumbar intervertebral disc level. Analysis of covariance showed that age was significantly associated with lumbar intervertebral disc degeneration (p<0.05). The value of β (parameter estimate) was positive at all lumbar intervertebral disc levels and was higher in the field group than in the administrative group at each level. In logistic regression analysis, type of job was statistically significant only with regard to the L4–5 intervertebral disc (OR 3.498, 95% CI 1.241 to 9.860).ConclusionsLumbar intervertebral disc degeneration is associated with age, and field work such as firefighting, emergency and rescue may accelerate degeneration in the L4–5 intervertebral disc. The effects of field work on lumbar intervertebral disc degeneration were not clear in discs other than at the level L4–5.

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Association between bone mineral density and lumbar disc degeneration

Cited by 38 publications

References 24 publications

Genetic Polymorphisms of Interleukin-1 Alpha and the Vitamin D Receptor in Mexican Mestizo Patients with Intervertebral Disc Degeneration

Genetic Polymorphisms of Interleukin-1 Alpha and the Vitamin D Receptor in Mexican Mestizo Patients with Intervertebral Disc Degeneration

Effect of bone mineral density on lumbar discs in young adults

Lumbar intervertebral disc degeneration and related factors in Korean firefighters

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