Association between C-reactive Protein and Insulin Resistance in a Japanese Population: The Minoh Study

Nakanishi, Noriyuki; Shiraishi, Tsunehito; Wada, Mariko

doi:10.2169/internalmedicine.44.542

Cited by 35 publications

(36 citation statements)

References 39 publications

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“…As in other studies that document the presence of chronic mild inflammation in obesity 30 and metabolic syndrome 31 , adults with MetS showed increased C-reactive protein and lower albumin serum levels than the control group members. In the MetS group, the increased serum CRP levels are due to higher levels of proinflammatory chemokines and cytokines, which are related to systemic and vascular low-grade inflammation and associated with abdominal obesity.…”

Section: Discussionsupporting

confidence: 77%

Frequency of metabolic syndrome and the food intake patterns in adults living in a rural area of Brazil

Silva¹,

Prata²,

Cunha³

2011

Rev. Soc. Bras. Med. Trop.

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Introduction: Metabolic syndrome (MetS), a risk factor for atherosclerosis and coronary heart disease, is related to an inadequate food intake pattern. Its incidence is increasing among Brazilian adults, including those living in rural areas. Our aim was not only to describe the frequency of MetS in adults with or without MetS but also to compare their food intake pattern as assessed by the healthy eating index (HEI) and serum albumin and C reactive protein (CRP) levels. Methods: Men and women (n = 246) living in a small village in Brazil were included. MetS was characterized according to the adult treatment panel (ATP III) criteria. Groups were compared by chi-square, student t or Mann-Whitney tests. Results: MetS was diagnosed in 15.4% of the cases. The MetS group showed higher CRP (1.8±1.2 vs. 1.0±0.9 mg/dl) and lower albumin (4.3±0.3 vs. 4.4±0.3 g/dl) serum levels compared to the control group. Additionally, the MetS group showed lower scores (median[range]) in the HEI compared to the control group (53.5[31.2-78.1] vs 58[29.7-89.5], respectively). The MetS group also had decreased scores for total fat and daily variety of food intake. Conclusions: The results suggest that adults with MetS displayed chronic mild inflammation and a poorer food intake pattern than the control group.

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Section: Discussionsupporting

confidence: 77%

Frequency of metabolic syndrome and the food intake patterns in adults living in a rural area of Brazil

Silva¹,

Prata²,

Cunha³

2011

Rev. Soc. Bras. Med. Trop.

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“…Some studies have suggested a possible role of subclinical inflammation in insulin resistance and glucose intolerance that only partly explained the link between obesity and impaired glucose homeostasis (32 ). It has also been documented that chronic, subclinical inflammation, as indicated by increased circulating CRP concentrations, is more strongly associated with postchallenge glycemia than with fasting glucose in nondiabetic adults.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between C-Reactive Protein and Atherosclerotic Risk Factors and Oxidative Stress Markers Among Young Persons 10–18 Years Old

et al. 2007

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Background: This study was undertaken to determine the association of serum C-reactive protein (CRP) with generalized and abdominal obesity, body fat composition, the metabolic syndrome, and oxidative stress markers among young people. Methods:We conducted a population-based study of 512 young people, aged 10 -18 years. We obtained anthropometric and blood pressure measurements. Fasting blood sugar, total cholesterol (TC), HDL-cholesterol, triglycerides, CRP, malondialdehyde (MDA), and conjugated diene (CDE) were quantified. LDL-cholesterol (LDL-C) was calculated for samples with TG <4.52 mmol/L Results: Mean triglycerides, waist and hip circumferences, percentage body fat, subcutaneous fat, and systolic blood pressure increased significantly with increasing body mass index (BMI). In contrast, the mean LDL and TC were higher in underweight than normal weight individuals, and then increased significantly from normal to higher BMI categories. Mean HDL cholesterol significantly decreased with increasing BMI. Overall, CRP, MDA, and CDE were significantly correlated with measures of abdominal obesity. Serum CRP, MDA, and CDE significantly increased in the upper quartiles of waist circumference. Study participants with higher CRP concentrations were more likely to have metabolic syndrome and high oxidative stress markers.

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“…However, CRP showed significant reduction compared to pre-treatment, which might be attributed to the association between CRP with insulin resistance [35,36] and adipocyte excess [37] supporting the effect of diet and weight loss on insulin resistance and consequently hyperandrogenism. The current experiment is limited to the mentioned diet therapy protocol, it's also limited to 12 weeks and 24 weeks measuring intervals, and to the exact measured dermatological, biochemical, and anthropometric parameters that were gathered.…”

Section: Discussionmentioning

confidence: 87%

Effect of Diet Control Therapy on the Dermatological Symptoms of Obese Polycystic Ovarian Syndrome Women: Repeated Measure Design

Mahmoud¹

2018

IJPR

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Background: Polycystic ovarian syndrome (PCOS) is the most common endocrinal disorder in female causing metabolic, cutaneous, and reproductive disorders.Purpose: This repeated measure study was designed to investigate the effect of diet control therapy on hyperandrogen symptoms (Acne & Hirsutism) in obese PCOS women.Subjects and Methods: Thirty PCOS obese women were recruited, their age ranged from 20 to 30 years and their BMI ranged from 30 to 34.9 kg/m 2 . All of them received diet control therapy, and were evaluated before, after 12 weeks and after 24 weeks of therapy through measuring their weight, C-reactive protein, luteinizing hormone (LH) / follicular stimulating hormone (FSH) ratio, androgen excess symptoms (modified Ferryman-Gallwey (mFG) scoring system & global acne grading system (GAGS).Results: Repeated Measure MANOVA showed a statistically significant difference (P < 0.05) between the pretreatment compared to after therapy (in both 12 and 24 weeks) in LH/FSH ratio, CRP, mFG and GAGS, however no significance difference was found between 12 weeks and 24 weeks for all the dependent variables. As well as, Pearson's product-moment correlation revealed a weak positive correlation between C-reactive protein and androgen excess symptoms (Acne & Hirsutism). Conclusion:Three months following the recommended diet control therapy is an effective therapy for improving the cutaneous symptoms and fertility through the hormonal variables of PCOS patients. Diet control therapy for another consequent three months is also recommended to keeping this improvement.

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Association between C-reactive Protein and Insulin Resistance in a Japanese Population: The Minoh Study

Cited by 35 publications

References 39 publications

Frequency of metabolic syndrome and the food intake patterns in adults living in a rural area of Brazil

Frequency of metabolic syndrome and the food intake patterns in adults living in a rural area of Brazil

Relationship Between C-Reactive Protein and Atherosclerotic Risk Factors and Oxidative Stress Markers Among Young Persons 10–18 Years Old

Effect of Diet Control Therapy on the Dermatological Symptoms of Obese Polycystic Ovarian Syndrome Women: Repeated Measure Design

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