Association between cardiovascular risk factors and venous thromboembolism in the elderly

Wang, Huijie; Rosendaal, Frits R.; Cushman, Mary; Vlieg, Astrid Hylckama

doi:10.1002/rth2.12671

Cited by 9 publications

(7 citation statements)

References 58 publications

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“…No significant impact of tobacco smoking on VTE risk was found by univariate MR analysis, which was consistent with the conclusions reached by multivariable MR analysis after controlling for potential effects. In contrast with many observational studies that have concluded that tobacco smoking (current or past) increased the risk of VTE, 7 8 9 10 the findings of the present study contradict this and instead support the conclusion of Blondon et al 12 13 14 46 that tobacco smoking is not associated with the risk of VTE.…”

Section: Discussioncontrasting

confidence: 99%

No Genetic Causality between Tobacco Smoking and Venous Thromboembolism: A Two-Sample Mendelian Randomization Study

Du,

Zheng,

Shen

et al. 2024

Thromb Haemost

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Background Given the current debate in clinical research about the relationship between tobacco smoking and the risk of venous thromboembolism (VTE), a Mendelian randomization (MR) study was conducted aimed at elucidating the causal associations of current and past tobacco smoking with the risk of VTE, from the perspective of genetics. Methods Two-sample univariate and multivariable MR analyses were designed, using summary-level data from large genome-wide association studies involving European individuals. Causality was primarily assessed using multiplicative fixed-effects or random-effects model and inverse variance weighting, supplemented by MR–Egger regression, MR-PRESSO, Cochran's Q test, and leave-one-out for sensitivity analysis to test the reliability of the results. Results In the univariate MR analysis, no significant causal effects were found between current tobacco smoking and the risk of VTE, deep vein thrombosis (DVT), and pulmonary embolism (PE). Similarly, no significant causal effects were found between past smoking and VTE, DVT, and PE. As for the multivariable MR analysis, results were consistent with univariate MR analysis, with no significant causal effect of either current or past tobacco smoking on the risk of VTE, DVT, and PE. Conclusion Evidence from both univariate and multivariable MR analyses demonstrated no significant causal relationships between current and past tobacco smoking and VTE, DVT, and PE. This contradicts positive correlations reported in some previous observational studies, which may be explained by other confounding factors. This provided genetic evidence for the conclusion reported in other observational studies that smoking did not affect VTE risk.

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Section: Discussioncontrasting

confidence: 99%

No Genetic Causality between Tobacco Smoking and Venous Thromboembolism: A Two-Sample Mendelian Randomization Study

Du,

Zheng,

Shen

et al. 2024

Thromb Haemost

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“…Therefore, the relationship between hypertension and VTE risk appears complex and requires further investigation to understand the roles of the involved variables. 34 In this study, the Wells' score obtained from the study population had a value of 15, with a percentage of 42.8% for a score of 1 and 57.2% for a score of 2. Therefore, the probability of DVT based on the Wells' score falls into the moderate range for all 35 (100%) patients.…”

Section: Resultsmentioning

confidence: 56%

The Relationship of D-dimer Levels and the Incident of Deep Vein Thrombosis in Acute Ischemic Stroke Patients at Haji Adam Malik General Hospital Medan

Gatot,

Syahrini Lubis

2023

Int J Res Rev

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Background: Deep Vein Thrombosis (DVT) is the formation of a thrombus in deep veins, often observed in stroke patients due to immobilization and infection during hospitalization. High D-dimer levels are associated with DVT in stroke patients. This study aims to evaluate the association between D-dimer levels as a diagnostic tool for DVT in acute ischemic stroke patients. Methods: This cross-sectional, retrospective study was conducted from May to August 2023. The study was carried out on acute ischemic stroke patients at Haji Adam Malik General Hospital, Medan, using consecutive sampling. Doppler ultrasound was used as the gold standard, and D-dimer data were analyzed using the SPSS program, employing the Chi-square test or Fisher's exact test. Results: Of the 49 patients, 35 met the inclusion criteria. Among the patients, 24 (68.6%) were male, 23 (65.7%) were over 50 years old, and 30 (85.7%) had a Body Mass Index (BMI) between 18-24.9. The mean D-dimer value was 2153.43 (±1506.88) ng/mL. All 21 (100%) DVT cases were asymptomatic. According to the Well's score, 15 patients scored 1 (42.8%), 20 patients (57.2%) scored 2, and the probability of DVT is in the moderate range for all 35 patients. The Fisher's Exact Test yielded a p-value of 0.028 (p<0.05). Conclusion: There is a significant relationship between D-dimer levels and the incidence of DVT in patients experiencing acute ischemic stroke. Keywords: Acute Ischemic Stroke, D-dimer, Deep Vein Thrombosis, Doppler Ultrasound

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“… 18 Mendelian randomization analyses 19 , 26 showed inverse associations of SBP and VTE. The Age and Thrombosis, Acquired and Genetic risk factors in the elderly (AT‐AGE) study 20 and the second Nord‐Trøndelag Health Study (HUNT 2) 25 found SBP and DBP were inversely correlated to VTE among elderly (age ≥70 years) and adult residents, respectively.…”

Section: Discussionmentioning

confidence: 99%

Associations of blood pressure in the third trimester and risk of venous thromboembolism postpartum

Li,

Wang,

Wang

et al. 2024

MedComm

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Studies on the associations of blood pressure (BP) and the risk of venous thromboembolism (VTE) had been performed neither among pregnant women nor in Chinese population. This study included participants of pregnant women from a retrospective multicenter cohort, between May 2020 and April 2023. Systolic BP (SBP) and diastolic BP (DBP) of the participants were measured in the third trimester. The incidences of VTE (including deep venous thrombosis and/or pulmonary embolism) at 42 days postpartum were followed. With regards to SBP, pregnant women in the Q1 (≤114 mmHg), Q2 (115–122 mmHg), and Q4 group (≥131 mmHg) had increased risk of VTE than those in Q3 group (123–130 mmHg), with ORs 4.48 [1.69, 11.85], 3.52 [1.30, 9.59], and 3.17 [1.12, 8.99], respectively. Compared with pregnant women with the Q4 of DBP (≥85 mmHg), women of Q1 (≤71 mmHg) were found to have elevated risk of VTE (OR 2.73 [1.25, 5.96]). A one standard deviation decrease of DBP (9 mmHg) was related with 37% elevated risk of VTE (OR 1.37 [1.05, 1.79]). This study demonstrated a U‐shaped association of SBP in the third trimester and VTE postpartum and inverse association of DBP in the third trimester and VTE postpartum.

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Association between cardiovascular risk factors and venous thromboembolism in the elderly

Cited by 9 publications

References 58 publications

No Genetic Causality between Tobacco Smoking and Venous Thromboembolism: A Two-Sample Mendelian Randomization Study

No Genetic Causality between Tobacco Smoking and Venous Thromboembolism: A Two-Sample Mendelian Randomization Study

The Relationship of D-dimer Levels and the Incident of Deep Vein Thrombosis in Acute Ischemic Stroke Patients at Haji Adam Malik General Hospital Medan

Associations of blood pressure in the third trimester and risk of venous thromboembolism postpartum

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