Association between CCN1 gene polymorphism and acute coronary syndrome in Chinese Han and Uygur populations

Abstract

Background CCN1 plays a crucial role in the modulation of cardiovascular diseases. However, whether CCN1 genetic variants are involved in the susceptibility of ACS remains unknown. Hence, the present study investigates the association between CCN1 polymorphisms and ACS among Han and Uygur populations in Xinjiang, China. Results In this case-control study, 1234 Han (547 ACS patients and 687 controls) and 932 Uygur (471 ACS patients and 461 controls) were genotyped using SNPscanTM for three single-nucleotide polymorphisms (SNPs, rs6576776, rs954353, and rs3753794) of the human CCN1 gene. In the Uygur population, we found that the detected frequencies of the C allele (25.3% vs. 18.3%, P<0.001) and CC genotype (6.4% vs. 3.0%, P=0.001) of rs6576776 were significantly higher in the ACS patients than in the control participants. Differences in rs6576776 regarding the dominant model (CC+CG vs. GG, 44.2% vs. 55.8%, P=0.001) and the recessive model (CC vs. CG+GG, 6.4% vs. 93.6%, P=0.016) were observed between the two groups. The frequencies of the GGC and AGC haplotypes in those with ACS were significantly higher than those in the control group (all P<0.05) in the Uygur population. After adjusting for hypertension, diabetes, lipids and smoking, all of which indicate that the rs6576776 C allele is associated with higher risk of ACS (odds ratio (OR)=1.798, 95% confidence interval (CI), 1.218-2.656, P=0.003). In Han population, neither the distribution of genotypes and alleles of the CCN1 gene three SNPs nor the distribution of haplotypes constructed with the three SNPs exhibited a significant difference between the ACS patients and control participants. Conclusions Our study document that the CCN1 gene rs6576776 C allele is associated with higher susceptibility of ACS and that the frequencies of GGC and AGC haplotypes are higher among the Uygur ACS patients.

CCN1 inhibition affects the function of endothelial progenitor cells under high-glucose condition

“…29 The CNN1 has low expression levels under normal conditions and high expression levels in pathological states such as atherosclerosis, colitis, diabetic retinopathy, rheumatoid arthritis, and Graves' orbitopathy, 13,31 and has been reported to have a causative role in atherosclerosis, 31 while CNN1 polymorphisms are associated with the risk of acute coronary syndrome (ACS) in humans. 32 Low CCN1 expression levels in rats with carotid balloon injury restore vascular smooth muscle cell (VSMC) proliferation, alleviating vascular intimal hyperplasia. 33 In addition, the suppression of CCN1 signaling results in reduced VSMC senescence in the smooth muscle cell layer of the human coronary artery.…”