Association between chemerin rs17173608 and vaspin rs2236242 gene polymorphisms and the metabolic syndrome, a preliminary report

Hashemi, Mohammad; Rezaei, Hamzeh; Eskandari-Nasab, Ebrahim; Kaykhaei, Mahmoud Ali; Zakeri, Zahra; Taheri, Mohsen

doi:10.1016/j.gene.2012.08.048

Cited by 41 publications

(41 citation statements)

References 42 publications

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“…This case-control study was done on 151 patients with and 149 without MeS which we used in previous studies [4,5]. MeS was defined using the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria [22] as described previously [23].…”

Section: Methodsmentioning

confidence: 99%

“…The prevalence of MeS is considerably increasing globally, and is becoming an important health problem [3]. The etiology of this syndrome is complex and is thought to be the result of interaction between genetic and environmental factors [4-6]. Uncoupling proteins (UCPs) are mitochondrial membrane transporters that disturb the coupling between the mitochondrial proton gradient and ATP synthesis.…”

Section: Introductionmentioning

confidence: 99%

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A 45-bp insertion/deletion polymorphism of UCP2 gene is associated with metabolic syndrome

Hashemi

Rezaei

Kaykhaei

et al. 2014

J Diabetes Metab Disord

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BackgroundMetabolic syndrome (MeS) is being recognized as a risk factor for insulin resistance and cardiovascular disease. The present study was aimed to find out the possible association between 45-bp I/D polymorphism of uncoupling protein 2 (UCP2) and MeS.MethodsDNA was extracted from peripheral blood of 151 subjects with and 149 subjects without MeS. 45-bp I/D variant of UCP2 was detected using polymerase chain reaction (PCR).ResultsOur finding showed that 45-bp I/D polymorphism was associated with protection against MeS (OR = 0.56, 95% CI = 0.34-0.92, p = 0.020 D/I vs DD and OR = 0.54, 95% CI = 0.34-0.86, p = 0.009; D/I + I/I vs D/D). The I allele decreased the risk of MeS (OR = 0.62, 95% CI = 0.44-0.90, p = 0.011) in comparison with D allele.ConclusionIn conclusion, our result suggests that 45-bp I/D polymorphism is associated with the risk of MeS, which remains to be cleared.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A 45-bp insertion/deletion polymorphism of UCP2 gene is associated with metabolic syndrome

Hashemi

Rezaei

Kaykhaei

et al. 2014

J Diabetes Metab Disord

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“…This method is simple, rapid and sensitive for the detection of single nucleotide polymorphism (43, 44). The adiponectin genomic sequence (NT_005612.16) was obtained from the National Center for Biotechnology Information (NCBI) (http://www.ncbi.nlm.nih.gov).…”

Section: Methodsmentioning

confidence: 99%

Association of Adiponectin rs1501299 and rs266729 Gene Polymorphisms With Nonalcoholic Fatty Liver Disease

et al. 2013

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BackgroundGenetic and environmental factors are important for the development of nonalcoholic fatty liver disease (NAFLD). Adiponectin is a white and brown adipose tissue hormone, and have been found to play essential roles in the regulation of energy homoeostasis. Recent reports have identified a possible role of adiponectin in NAFLD via PPARγ pathway.ObjectivesThe present study was designed to find out the impact of adiponectin rs1501299 (276G/T) and rs266729 (-11377C/G) gene polymorphisms in NAFLD.Patients and MethodsEighty-three patients with diagnosis of NAFLD, and 93 healthy subjects were included in the study. Tetra ARMS-PCR was designed to detect single nucleotide polymorphisms.ResultsA significant difference was found between NAFLD and control group regarding the rs266729 polymorphism (χ2 = 7.35, P = 0.025). The rs266729 polymorphism increased the risk of NAFLD in codominant (CC vs. CG: OR = 2.18, 95% CI = 1.16 - 4.12, P = 0.016) and dominant (CC vs. CG/GG: OR = 2.31, 95% CI = 1.25 - 4.27; P = 0.008) inheritance tested models. The G allele increased the risk of NAFLD (OR = 1.63, 95% CI = 1.03 - 2.57, P = 0.037) in comparison with C allele. No significant difference was found between the groups concerning adiponectin rs1501299 gene polymorphism (χ2 = 0.70, P = 0.697).Conclusionsadiponectin rs266729 polymorphism might be a candidate gene, which determines the susceptibility to NAFLD. Larger studies are necessary to confirm these findings in various populations.

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“…The exact pathological mechanism of MetS has not yet been clarified but it has been established that both environmental and genetic factors are involve [11-13]. ApolipoproteinA5 (ApoA5) gene which is located on chromosome 11q23 (NC_000011.9) on APOA1/C3/A4/A5 gene cluster has been recently discovered [14].…”

Section: Introductionmentioning

confidence: 99%

Association of two common polymorphisms of apolipoprotein A5 gene with metabolic syndrome indicators in a North Iranian population, a cross-sectional study

Halalkhor

Jalali

Hajian‐Tilaki

et al. 2014

J Diabetes Metab Disord

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BackgroundMetabolic syndrome is an obesity dependent disorder with a worldwide high prevalence. Regarding the high prevalence of Metabolic syndrome in Iran we analyzed the influence of -1131T>C (rs662799) and c.56C>G (S19W, rs3135506) polymorphisms of the novel apolipoprotein gene, ApoA5, on some Metabolic Syndrome indicators in population from north of Iran.Methods199 volunteers from Babol city-Iran were divided in two groups of low (N = 99, TG ≤ 103 mg/dl) and high (N = 100, TG ≥ 150 mg/dl) serum levels of Triglycerides (TG). We amplified the gene fragments containing -1131T>C and c.56C>G polymorphisms by PCR method and revealed the polymorphisms by RFLP analysis.ResultsWe found a significant association (p = 0.016, Independent t-test) between high levels of TG and -1131T>C polymorphism but not between this polymorphism and serum HDL-C concentrations. Carriers of the C allele had a 1.97 times higher odds ratio to be in the high-TG group than those of the TT genotype (95%, CI = 1.05-3.68). We observed no association between -1131T>C polymorphism with either Waist-to-Hip Ratio (WHR) or Body-Mass-Index (BMI). In the case of c.56C>G polymorphism, although it showed a significant relationship with WHR (p = 0/040, Independent t-test), but failed to correlate with either levels of TG (p = 0.594) or HDL-C (p = 0.640) in serum.ConclusionOur study confirms that ApoA5 gene polymorphisms, -1131T>C and c.56C>G are associated with the two criteria of Metabolic Syndrome, TG and WHR, respectively.

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Association between chemerin rs17173608 and vaspin rs2236242 gene polymorphisms and the metabolic syndrome, a preliminary report

Cited by 41 publications

References 42 publications

A 45-bp insertion/deletion polymorphism of UCP2 gene is associated with metabolic syndrome

A 45-bp insertion/deletion polymorphism of UCP2 gene is associated with metabolic syndrome

Association of Adiponectin rs1501299 and rs266729 Gene Polymorphisms With Nonalcoholic Fatty Liver Disease

Association of two common polymorphisms of apolipoprotein A5 gene with metabolic syndrome indicators in a North Iranian population, a cross-sectional study

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