Association between choroid plexus volume and cognition in Parkinson disease

Jeong, Seong Ho; Jeong, Heisawn; Sunwoo, Mun Kyung; Ahn, Sung Soo; Lee, Seung‐Koo; Lee, Phil Hyu; Kim, Yun Joong; Sohn, Young H.; Park, Chae Jung; Chung, Seok Jong

doi:10.1111/ene.15999

Cited by 14 publications

(6 citation statements)

References 45 publications

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“…The present study showed abnormally elevated CSF and CP volumes in SCA3 patients compared to HCs. This enlargement in CSF and CP volume has been reported to be potentially linked to neuroinflammation and glymphatic impairment in neurodegenerative diseases [28, 31, 32] and psychosis spectrum [45, 46] . Therefore, the impaired glymphatic clearance mechanisms in SCA3 may mitigate glymphatic dysfunction by enhancing waste clearance through increased production and transmission of functional units in the CSF and CP [47] .…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies pointed that functional dysregulation of the CP-CSF reflected the common underlying mechanism in the pathophysiology of neurodegenerative diseases [30] . Dysfunction of the CP and CSF flow could precede the neurological symptoms and affect glymphatic function in neurodegenerative diseases [28, 31, 32] . Meanwhile, DTI-ALPS index is also a recently established non-invasive method to quantify the dynamics of subcortical glymphatic flow, especially water movement along the periventricular pathway, which is associated with the driving force of glymphatic function [33] .…”

Section: Introductionmentioning

confidence: 99%

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Regional Glymphatic Dysfunction is linked to Spinocerebellar Ataxia Type 3 pathophysiology

Hua,

Xu,

Zhang

et al. 2024

Preprint

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Spinocerebellar ataxia type 3 (SCA3) involves neuroinflammation and imbalance between production and clearance of proteins which affects the glymphatic system, the lymphatic-like, fluid-transport system in the brain. However, it is unclear whether SCA3 is related to impairments in glymphatic function. Using multimodal imaging data, 34 SCA3 patients and 36 age-, sex- and educational matched healthy controls (HCs) were compared using multiple glymphatic measurements, including choroid plexus (CP) and cerebrospinal fluid (CSF) volume, diffusion tensor imaging along the perivascular (DTI-ALPS) index, and coupling relationship between blood-oxygen-level-dependent signals and CSF flow (BOLD-CSF coupling). Then, we evaluated regional glymphatic function by dividing DTI-ALPS and BOLD-CSF coupling into anterior, middle, posterior, and cerebellum regions, thereby identifying the spatial variation of glymphatic function in the two groups. We demonstrated that compared with HCs, larger CP and CSF volumes were found in SCA3 patients. More importantly, for DTI-ALPS index and BOLD-CSF coupling, these surrogate markers for glymphatic clearance were weaker in SCA3 patients. Furthermore, altered regional glymphatic functions were most prominent in midbrain, cerebellum and middle regions. Crucially, the altered midbrain, cerebellum, middle and global glymphatic functions were accompanied by the severity of ataxia and other SCA3 symptoms. Similar to other neurodegenerative disorders, the association between multiple glymphatic indexes and SCA3 symptoms suggested that waste clearance is disrupted in SCA3 patients, which shed light on the pathogenesis of this disease from a glymphatic lens. Our findings highlighted the dysregulated glymphatic function as a novel diagnostic marker for SCA3.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Regional Glymphatic Dysfunction is linked to Spinocerebellar Ataxia Type 3 pathophysiology

Hua,

Xu,

Zhang

et al. 2024

Preprint

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“…Biondi ring tangles were present in the cytoplasm of CPEs in aged brains, especially AD brains [76]. The CP volume was associated with frontal or executive function, followed by the dementia conversion risk in patients with Parkinson disease (PD) [89]. The CP volume had the potential to serve as a biomarker for motor disabilities in PD patients [90].…”

Section: Cp Changes In Brain Disordersmentioning

confidence: 99%

“…The CP volume is associated with frontal or executive function, followed by the dementia conversion risk. [89] The CP volume has the potential to serve as a biomarker of motor disabilities.…”

Section: Psychosismentioning

confidence: 99%

Transporters, Ion Channels, and Junctional Proteins in Choroid Plexus Epithelial Cells

Ueno,

Chiba,

Murakami

et al. 2024

Biomedicines

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The choroid plexus (CP) plays significant roles in secreting cerebrospinal fluid (CSF) and forming circadian rhythms. A monolayer of epithelial cells with tight and adherens junctions of CP forms the blood–CSF barrier to control the movement of substances between the blood and ventricles, as microvessels in the stroma of CP have fenestrations in endothelial cells. CP epithelial cells are equipped with several kinds of transporters and ion channels to transport nutrient substances and secrete CSF. In addition, junctional components also contribute to CSF production as well as blood–CSF barrier formation. However, it remains unclear how junctional components as well as transporters and ion channels contribute to the pathogenesis of neurodegenerative disorders. In this manuscript, recent findings regarding the distribution and significance of transporters, ion channels, and junctional proteins in CP epithelial cells are introduced, and how changes in expression of their epithelial proteins contribute to the pathophysiology of brain disorders are reviewed.

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“…This method has also been applied to quantify in vivo glymphatic activity in various neurological disorders, including idiopathic normal pressure hydrocephalus (iNPH) [ 25 ], Parkinson’s disease [ 26 ], and multiple sclerosis [ 27 ] (MS), consistently revealing that reduced DTI-ALPS values are associated with disease severity. Choroid plexus volume, suggested as a driving force behind glymphatic function, has demonstrated associations with disease severity in conditions like frontotemporal dementia (FTD) [ 28 ] and AD [ 29 ] and has been used to predict conversion to Parkinson’s disease dementia [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

The relationship between amyloid pathology, cerebral small vessel disease, glymphatic dysfunction, and cognition: a study based on Alzheimer’s disease continuum participants

Hong,

Luo

et al. 2024

Alz Res Therapy

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Background Glymphatic dysfunction is a crucial pathway for dementia. Alzheimer’s disease (AD) pathologies co-existing with cerebral small vessel disease (CSVD) is the most common pathogenesis for dementia. We hypothesize that AD pathologies and CSVD could be associated with glymphatic dysfunction, contributing to cognitive impairment. Method Participants completed with amyloid PET, diffusion tensor imaging (DTI), and T2 fluid-attenuated inversion-recovery (FLAIR) sequences were included from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). White matter hyperintensities (WMH), the most common CSVD marker, was evaluated from T2FLAIR images and represented the burden of CSVD. Amyloid PET was used to assess Aβ aggregation in the brain. We used diffusion tensor image analysis along the perivascular space (DTI-ALPS) index, the burden of enlarged perivascular spaces (PVS), and choroid plexus volume to reflect glymphatic function. The relationships between WMH burden/Aβ aggregation and these glymphatic markers as well as the correlations between glymphatic markers and cognitive function were investigated. Furthermore, we conducted mediation analyses to explore the potential mediating effects of glymphatic markers in the relationship between WMH burden/Aβ aggregation and cognition. Results One hundred and thirty-three participants along the AD continuum were included, consisting of 40 CN − , 48 CN + , 26 MCI + , and 19 AD + participants. Our findings revealed that there were negative associations between whole-brain Aβ aggregation (r = − 0.249, p = 0.022) and WMH burden (r = − 0.458, p < 0.001) with DTI-ALPS. Additionally, Aβ aggregation (r = 0.223, p = 0.041) and WMH burden (r = 0.294, p = 0.006) were both positively associated with choroid plexus volume. However, we did not observe significant correlations with PVS enlargement severity. DTI-ALPS was positively associated with memory (r = 0.470, FDR-p < 0.001), executive function (r = 0.358, FDR-p = 0.001), visual-spatial (r = 0.223, FDR-p < 0.040), and language (r = 0.419, FDR-p < 0.001). Conversely, choroid plexus volume showed negative correlations with memory (r = − 0.315, FDR-p = 0.007), executive function (r = − 0.321, FDR-p = 0.007), visual-spatial (r = − 0.233, FDR-p = 0.031), and language (r = − 0.261, FDR-p = 0.021). There were no significant correlations between PVS enlargement severity and cognitive performance. In the mediation analysis, we found that DTI-ALPS acted as a mediator in the relationship between WMH burden/Aβ accumulation and memory and language performances. Conclusion Our study provided evidence that both AD pathology (Aβ) and CSVD were associated with glymphatic dysfunction, which is further related to cognitive impairment. These results may provide a theoretical basis for new targets for treating AD.

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Association between choroid plexus volume and cognition in Parkinson disease

Cited by 14 publications

References 45 publications

Regional Glymphatic Dysfunction is linked to Spinocerebellar Ataxia Type 3 pathophysiology

Regional Glymphatic Dysfunction is linked to Spinocerebellar Ataxia Type 3 pathophysiology

Transporters, Ion Channels, and Junctional Proteins in Choroid Plexus Epithelial Cells

The relationship between amyloid pathology, cerebral small vessel disease, glymphatic dysfunction, and cognition: a study based on Alzheimer’s disease continuum participants

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