Association between chronic immune-mediated inflammatory diseases and cardiovascular risk

Baena-Díez, José Miguel; García-Gil, Maria; Comas-Cufí, Marc; Ramos, Rafael; Prieto-Alhambra, Daniel; Salvador-González, Betlem; Elosúa, Roberto; Dégano, Irene R.; Peñafiel, Judith; Grau, María

doi:10.1136/heartjnl-2017-311279

Cited by 76 publications

(55 citation statements)

References 29 publications

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“…The potential effect of SNP genotype on tissue expression (eQTL) of genes is reported from data published on the GTEx (https://gtexportal.org/home/) [52].…”

Section: Discussionmentioning

confidence: 99%

Analysis of the genetic variants associated with circulating levels of sgp130. Results from the IMPROVE study

et al. 2020

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The genes regulating circulating levels of soluble gp130 (sgp130), the antagonist of the inflammatory response in atherosclerosis driven by interleukin 6, are largely unknown. Aims of the present study were to identify genetic loci associated with circulating sgp130 and to explore the potential association between variants associated with sgp130 and markers of subclinical atherosclerosis. The study is based on IMPROVE (n = 3703), a cardiovascular multicentre study designed to investigate the determinants of carotid intima media thickness, a measure of subclinical atherosclerosis. Genomic DNA was genotyped by the CardioMetaboChip and ImmunoChip. About 360,842 SNPs were tested for association with log-transformed sgp130, using linear regression adjusted for age, gender, and population stratification using PLINK v1.07. A p value of 1 × 10 −5 was chosen as threshold for significance value. In an exploratory analysis, SNPs associated with sgp130 were tested for association with c-IMT measures. We identified two SNPs significantly associated with sgp130 levels and 24 showing suggestive association with sgp130 levels. One SNP (rs17688225) on chromosome 14 was positively associated with sgp130 serum levels (β = 0.03 SE = 0.007, p = 4.77 × 10 −5 ) and inversely associated with c-IMT (c-IMT mean-max β = −0.001 SE = 0.005, p = 0.0342). Our data indicate that multiple loci regulate sgp130 levels and suggest a possible common pathway between sgp130 and c-IMT measures.

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“…The potential effect of SNP genotype on tissue expression (eQTL) of genes is reported from data published on the GTEx (https://gtexportal.org/home/) [52].…”

Section: Discussionmentioning

confidence: 99%

Analysis of the genetic variants associated with circulating levels of sgp130. Results from the IMPROVE study

et al. 2020

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“…there is emerging evidence that connective tissue disease and, to a somewhat lesser degree, inflammatory bowel disease are associated with increased cardiovascular risk. 46 In 2017, the European League Against Rheumatism (EULAR) updated its CVD risk management guideline, 47 but this is now being updated again. The evidence supporting increased CVD risk has strengthened, and is related to both traditional and non-traditional risk factors, the latter including inflammatory activity, clinical disease phenotype and serum antibody profile.…”

Section: Clinical Conditions Affecting Cardiovascular Riskmentioning

confidence: 99%

Update on cardiovascular prevention in clinical practice: A position paper of the European Association of Preventive Cardiology of the European Society of Cardiology

Piepoli

Abreu

Albus

et al. 2019

Eur J Prev Cardiolog

181

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European guidelines on cardiovascular prevention in clinical practice were first published in 1994 and have been regularly updated, most recently in 2016, by the Sixth European Joint Task Force. Given the amount of new information that has become available since then, components from the task force and experts from the European Association of Preventive Cardiology of the European Society of Cardiology were invited to provide a summary and critical review of the most important new studies and evidence since the latest guidelines were published. The structure of the document follows that of the previous document and has six parts: Introduction (epidemiology and cost effectiveness); Cardiovascular risk; How to intervene at the population level; How to intervene at the individual level; Disease-specific interventions; and Settings: where to intervene? In fact, in keeping with the guidelines, greater emphasis has been put on a population-based approach and on disease-specific interventions, avoiding re-interpretation of information already and previously considered. Finally, the presence of several gaps in the knowledge is highlighted.

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“…Platelet surface molecules including GPIIb/IIIa, GPIba, P‐selectin, and the CD40/CD40L dyad are crucially involved in the interaction with endothelial cells, leukocytes, and extracellular matrix molecules, which directly affects atherogenesis . In the last few years, several reports have discussed possible links between cardiovascular (CVD) and chronic inflammatory diseases as rheumatoid arthritis, systemic erythematosus lupus, inflammatory bowel disease, and periodontitis …”

Section: Introductionmentioning

confidence: 99%

Periodontal status, vascular reactivity, and platelet aggregation changes in rats submitted to hypercholesterolemic diet and periodontitis

Silva

Motta

Soares

et al. 2020

J of Periodontal Research

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Background and objectives: Periodontitis can corroborate with development and progression of atherosclerosis and a possible bidirectional interaction between both pathologies has been hypothesized. The aim of this work was to study the interactions between diet-induced hypercholesterolemia and ligature-induced periodontitis in Wistar rats submitted to both conditions. Material and methods: Animals were divided into four experimental groups: C (control: standard diet without periodontitis), Perio (periodontitis plus standard diet), HC (high cholesterol diet without periodontitis), and HC + Perio (high cholesterol diet plus periodontitis). The diets were offered for 45 days and a silk ligature was applied in the lower first molars of Perio and HC-Perio animals on day 34 and maintained for 11 days until euthanasia. The mandibles were excised, and alveolar bone loss was determined by macroscopic and micro-tomographic (µ-CT) imaging. Blood samples were obtained, and platelet aggregation was induced in plasma rich in platelets by adenosine diphosphate (ADP) and collagen. Endothelium-dependent vascular reactivity and protein expression of endothelial (eNOS), phosphorylated endothelial (peNOS), and inducible (iNOS) nitric oxide synthases were evaluated in aorta samples. Results:The HC diet combined with periodontitis (HC + Perio group) was associated with an increased alveolar bone loss, when compared to the other groups. Both in Perio and HC groups, platelet aggregation induced by ADP or collagen was increased, while maximum aortic relaxation induced by acetylcholine was decreased.Periodontitis or HC diet alone decreased the expression of peNOS and HC diet increased the expression of iNOS. In contrast, no additive or synergistic effects were found in vascular reactivity or in platelet aggregation when the two conditions were associated (HC + Perio group). Conclusion:Hypercholesterolemia accelerated the process of bone loss induced by periodontitis while a high cholesterol diet or periodontitis individually increased

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Association between chronic immune-mediated inflammatory diseases and cardiovascular risk

Abstract: Systemic connective tissue disorders and rheumatoid arthritis conferred the highest cardiovascular risk and population impact, followed by inflammatory bowel diseases.

Cited by 76 publications

References 29 publications

Analysis of the genetic variants associated with circulating levels of sgp130. Results from the IMPROVE study

Analysis of the genetic variants associated with circulating levels of sgp130. Results from the IMPROVE study

Update on cardiovascular prevention in clinical practice: A position paper of the European Association of Preventive Cardiology of the European Society of Cardiology

Periodontal status, vascular reactivity, and platelet aggregation changes in rats submitted to hypercholesterolemic diet and periodontitis

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