Association between chronic kidney disease and mortality in patients with a confirmed COVID-19 diagnosis

Puicón-Suárez, Jacqueline Betsabe; Zeña‐Ñañez, Sandra; Failoc‐Rojas, Virgilio E.

doi:10.7717/peerj.13437

Cited by 7 publications

(5 citation statements)

References 43 publications

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“…In addition, we observed that comorbidity of CKD was a risk factor for in-patient mortality. In the study of Puicón-Suárez et al, 39 patients with CKD and COVID-19 experienced higher mortality than those without CKD also in a Latin American population. CKD causes a chronic inflammatory process that promotes a dysregulated immune response to COVID-19 infection, resulting in hyperinflammation, activation and endothelial damage 40…”

Section: Discussionmentioning

confidence: 90%

Predictors of mortality in hospitalised patients with COVID-19: a 1-year case–control study

Camacho-Domínguez,

Rojas,

Herrán

et al. 2024

BMJ Open

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BackgroundA paucity of predictive models assessing risk factors for COVID-19 mortality that extend beyond age and gender in Latino population is evident in the current academic literature.ObjectivesTo determine the associated factors with mortality, in addition to age and sex during the first year of the pandemic.DesignA case–control study with retrospective revision of clinical and paraclinical variables by systematic revision of clinical records was conducted. Multiple imputations by chained equation were implemented to account for missing variables. Classification and regression trees (CART) were estimated to evaluate the interaction of associated factors on admission and their role in predicting mortality during hospitalisation. No intervention was performed.SettingHigh-complexity centre above 2640 m above sea level (masl) in Colombia.ParticipantsA population sample of 564 patients admitted to the hospital with confirmed COVID-19 by PCR. Deceased patients (n=282) and a control group (n=282), matched by age, sex and month of admission, were included.Main outcome measureMortality during hospitalisation.Main resultsAfter the imputation of datasets, CART analysis estimated 11 clinical profiles based on respiratory distress, haemoglobin, lactate dehydrogenase, partial pressure of oxygen to inspired partial pressure of oxygen ratio, chronic kidney disease, ferritin, creatinine and leucocytes on admission. The accuracy model for prediction was 80.4% (95% CI 71.8% to 87.3%), with an area under the curve of 78.8% (95% CI 69.63% to 87.93%).ConclusionsThis study discloses new interactions between clinical and paraclinical features beyond age and sex influencing mortality in COVID-19 patients. Furthermore, the predictive model could offer new clues for the personalised management of this condition in clinical settings.

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Section: Discussionmentioning

confidence: 90%

Predictors of mortality in hospitalised patients with COVID-19: a 1-year case–control study

Camacho-Domínguez,

Rojas,

Herrán

et al. 2024

BMJ Open

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Section: Discussionmentioning

confidence: 90%

Does workforce explain the relationship between funding and patient experience? A mediation analysis of primary care data in England

Salant,

Massou,

Awan

et al. 2024

BMJ Open

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ObjectivesTo determine whether general practitioner (GP) workforce contributes to the link between practice funding and patient experience. Specifically, to determine whether increased practice funding is associated with better patient experience, and to what degree an increase in workforce accounts for this relationship.SettingPrimary care practice level analysis of workforce, funding and patient experience of all NHS practices in England.Primary and secondary outcome measuresThe link between NHS-provided funding to general practice (payments per patient) and patient experience, as per the General Practice Patient Survey, was evaluated. Subsequently, mediation analysis, adjusted for covariates, was used to scrutinise the extent to which GP workforce accounts for this relationship (measured as the number of GPs per 10 000 patients).ParticipantsWe included all general practices in England for which there was relevant data for each primary variable. Atypical practices were excluded, such as those with a patient list size of 0 or where the workforce variable was recorded as being more than 3 SD from the mean. After exclusion, 6139 practices were included in the final analysis.ResultsWe found that workforce (GPs per 10 000 population) significantly (p<0.001) acts as a mediator in the effect of practice funding on overall patient experience even after adjusting for rurality, sex and age, and deprivation. On average, the mediated effect constitutes 30% of the total effect of practice funding on patient experience.ConclusionsThe increase in the number of doctors in primary care in England appears to be a mechanism through which augmented practice funding could positively impact patient experience. Policy initiatives targeting improved patient experience should prioritise considerations related to workforce and practice funding.

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“…Moreover, DM in patients with COVID-19 infection was associated with a 0.549-fold increase in mortality 25 . Although CVD and DM were identified as high-risk factors for COVID-19 earlier than CKD, CKD had a more significant impact on mortality 14 , 26 .…”

Section: Discussionmentioning

confidence: 99%

COVID-19 and chronic kidney disease: a bibliometric analysis

Jiang,

Chen,

Zhao

et al. 2023

Annals of Medicine &Amp; Surgery

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Background: The coronavirus disease 2019(COVID-19) pandemic has caused over 656 million confirmed cases and over 6.6 million deaths worldwide. Chronic kidney disease (CKD) is considered a high-risk factor for COVID-19; therefore, considerable research has been conducted in this field. Therefore, this study aims to conduct a bibliometric analysis of publications related to COVID-19 and CKD. Methods: Publications were retrieved from the Web of Science Core Collection database on January 16, 2023 and screened based on inclusion criteria. Then we used Microsoft Excel and CiteSpace to analyze the included publications from the following seven aspects: countries/regions, institutions, journals, authors, cited references, and keywords. Results: In total, 622 publications were included in the study. The USA has the most publications in this field, followed by China. The Icahn School of Medicine at Mount Sinai and Harvard Medical School had the highest number of publications in the field. Journal of Clinical Medicine had the largest number of publications, and Lancet was the most cited journal. Alberto Ortiz was the author with the largest number of publications, but there were no influential authors in this field. The highly cited references are mainly clinical studies on COVID-19. Research hotspots in this field include end-stage recent disease, cardiovascular disease, kidney metastasis, diabetes Mellitus, acute kidney injury, meta-analysis, and consistent plasma. Conclusions: The USA, China, and some European countries and their institutions are major contributors to these publications. End-stage renal disease, acute kidney injury, kidney transplantation and convalescent plasma are current hot topics in the field.

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Association between chronic kidney disease and mortality in patients with a confirmed COVID-19 diagnosis

Cited by 7 publications

References 43 publications

Predictors of mortality in hospitalised patients with COVID-19: a 1-year case–control study

Predictors of mortality in hospitalised patients with COVID-19: a 1-year case–control study

Does workforce explain the relationship between funding and patient experience? A mediation analysis of primary care data in England

COVID-19 and chronic kidney disease: a bibliometric analysis

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