Association between chronic mechanical irritation and oral cancer needs more original research

Piemonte, Eduardo; Lazos, Jerónimo; Gilligan, Gerardo; Pánico, René

doi:10.1111/odi.14099

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…12 The persistent trauma can induce the disruption of the normal physical architecture of the extracellular matrix, promoting oncogene expression, increasing the hyperproliferative status, and creating an inflammatory microenvironment. 12 However, the exact pathogenesis is questionable and the traumatic event alone is unable to develop an OSCC 13 without the presence of genetic alteration such as loss of heterozygosity. 12 Although the mouth is visually accessible for examination, the diagnosis of OSCC is frequently delayed because it may be difficult to distinguish clinically from other diseases.…”

Section: Discussionmentioning

confidence: 99%

The early detection of tongue cancer with the etiology of mechanical trauma

Setyawan,

Anang,

Rahmawati

et al. 2023

Dent. J.

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Background: Oral squamous cell carcinoma (OSCC) occurs in approximately 95% of people older than 40 years; usually, it is diagnosed at the age of 60 years. The etiology of OSCC is multifactorial. Chronic mechanical trauma due to sharp teeth has also been suggested as an etiology of oral squamous of the tongue. Purpose: This case report aimed to describe the etiology of OSCC resulting from mechanical trauma and to prevent further metastasis by correctly diagnosing the lesion earlier. Case: A 49-year-old female patient presented with painful and swollen stomatitis two months ago. No submandibular lymph nodes were palpable. An indurated ulceration and sharp teeth on the right region of the jaw were obtained from the intraoral examination. Malignancy was concluded from Histopathology Examination (HPE) and Magnetic Resonance Imaging (MRI) radiography results. Case Management: Multiple extractions were chosen to eliminate the etiology of mechanical trauma due to sharp teeth, and the patient underwent hemiglossectomy with the keyhole method. Postoperative, the histopathology examination revealed an OSCC of the tongue. The patient is currently in the second cycle of chemotherapy by hematologist-oncologists. Conclusion: The early appropriate diagnosis of a tongue ulcer can prevent metastasis, decrease morbidity, and increase quality of life.

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Section: Discussionmentioning

confidence: 99%

The early detection of tongue cancer with the etiology of mechanical trauma

Setyawan,

Anang,

Rahmawati

et al. 2023

Dent. J.

View full text Add to dashboard Cite

show abstract

“…Chronic mechanical irritation and oral cancer: Less evidence to support its role than the one ruling it out Dear Editor, We appreciated the Letter from Piemonte et al commenting on our review (Pentenero et al, 2021;Piemonte et al, 2021). Indeed, in both the recent and past literature, several authors reported the presence of chronic mechanic irritation (CMI) as an outstanding apparent etiological factor for oral squamous cell carcinoma (OSCC).…”

Section: E T T E R T O T H E E D I T O Rmentioning

confidence: 98%