Association between chronic obstructive pulmonary disease and PM2.5 in Taiwanese nonsmokers

Huang, Heng; Lin, Frank Cheau‐Feng; Wu, Ming; Nfor, Oswald Ndi; Hsu, Shu Yi; Lung, Chia Chi; Ho, Chien Chang; Chen, Chih-Yi; Liaw, Yung Po

doi:10.1016/j.ijheh.2019.03.009

Cited by 40 publications

(20 citation statements)

References 24 publications

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“…5 at the concentrations of 21.42-23.94, 23.94-31.86, or higher than 31.86 µg/m 3 significantly increased development of COPD (vs. <21.42 µg/m 3 ) (Guo et al, 2018). Another study conducted in adult non-smokers showed similar results (Huang et al, 2019). It is reported that exposure to PM 2 .…”

Section: Modest Elevation In Pm 25 Levelsmentioning

confidence: 72%

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More to Explore: Further Definition of Risk Factors for COPD – Differential Gender Difference, Modest Elevation in PM2.5, and e-Cigarette Use

et al. 2021

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Chronic obstructive pulmonary disease (COPD) is a severe respiratory disease with high morbidity and mortality, representing the third leading cause of death worldwide. Traditional risk factors for COPD include aging, genetic predisposition, cigarette smoking, exposure to environmental pollutes, occupational exposure, and individual or parental respiratory disease history. In addition, latest studies have revealed novel and emerging risk factors. In this review, differential gender difference as a factor for COPD development at different territories is discussed for the first time. First, women seem to have more COPD, while more women die of COPD or have more severe COPD, in Western societies. This seems different from the impression that COPD dominants in men, which is true in Eastern societies. It might be related to higher rate of cigarette smoking in women in developed countries (i.e., 12.0% of women in United States smoke vs. 2.2% in China). Nonetheless, women in Eastern societies are exposed to more biomass usage. Second, modest elevation in PM2.5 levels at >∼21.4–32.7 μg/m3, previously considered “cleaner air,” is associated with incidence of COPD, indicating that more stringent goals should be set for the reduction of PM2.5 levels to prevent COPD development. Last but not least, e-cigarette use, which has become an epidemic especially among adolescents as officially declared by the United States government, has severe adverse effects that may cause development of COPD early in life. Built upon an overview of the established risk factors for COPD primarily focusing on cigarette smoking and environmental pollutions, the present review further discusses novel concepts, mechanisms, and solutions evolved around the emerging risk factors for COPD discussed above, understanding of which would likely enable better intervention of this devastating disease.

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Section: Modest Elevation In Pm 25 Levelsmentioning

confidence: 72%

“…It is reported that exposure to PM 2 . 5 at concentrations higher than 38.98 μg/m 3 is associated with development of COPD ( Huang et al, 2019 ). A study of 5,993 residents (aged of 20 or above) from Guangdong, China, has reported that a higher year-round daily mean of PM 2 .…”

Section: Emerging Novel Risk Factors For Copdmentioning

confidence: 99%

More to Explore: Further Definition of Risk Factors for COPD – Differential Gender Difference, Modest Elevation in PM2.5, and e-Cigarette Use

et al. 2021

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“…Zeka et al revealed that PM was positively associated with daily mortality, and the mortality percentage was higher in densely populated areas [ 14 ]. Besides, pollution due to PM 2.5 when combined with cigarette smoking increases the risk of COPD [ 44 , 45 ]. Differences in the proportion of smokers may also influence the health impacts of PM.…”

Section: Discussionmentioning

confidence: 99%

Short-Term Effects of Particulate Matter and Its Constituents on Emergency Room Visits for Chronic Obstructive Pulmonary Disease: A Time-Stratified Case-Crossover Study in an Urban Area

Huang

Chen

et al. 2021

IJERPH

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Background: PM2.5 exposure is associated with pulmonary and airway inflammation, and the health impact might vary by PM2.5 constitutes. This study evaluated the effects of increased short-term exposure to PM2.5 constituents on chronic obstructive pulmonary disease (COPD)-related emergency department (ED) visits and determined the susceptible groups. Methods: This retrospective observational study performed in a medical center from 2007 to 2010, and enrolled non-trauma patients aged >20 years who visited the emergency department (ED) and were diagnosed as COPD. Concentrations of PM2.5, PM10, and the four PM2.5 components, including organic carbon (OC), elemental carbon (EC), nitrate (NO3−), and sulfate (SO42−), were collected by three PM supersites in Kaohsiung City. We used an alternative design of the Poisson time series regression models called a time-stratified and case-crossover design to analyze the data. Results: Per interquartile range (IQR) increment in PM2.5 level on lag 2 were associated with increments of 6.6% (95% confidence interval (CI), 0.5–13.0%) in risk of COPD exacerbation. An IQR increase in elemental carbon (EC) was significantly associated with an increment of 3.0% (95% CI, 0.1–5.9%) in risk of COPD exacerbation on lag 0. Meanwhile, an IQR increase in sulfate, nitrate, and OC levels was not significantly associated with COPD. Patients were more sensitive to the harmful effects of EC on COPD during the warm season (interaction p = 0.019). The risk of COPD exacerbation after exposure to PM2.5 was higher in individuals who are currently smoking, with malignancy, or during cold season, but the differences did not achieve statistical significance. Conclusion: PM2.5 and EC may play an important role in COPD events in Kaohsiung, Taiwan. Patients were more susceptible to the adverse effects of EC on COPD on warm days.

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“…It has been estimated that an increase in 10 µg/m 3 on average per day of two-day personal exposure to PM 2.5 is associated with an increase in respiratory symptoms in adults with COPD (10). Huang et al (11) examined the association of COPD and PM 2.5 in non-smokers in Taiwan. The population-based study included 3,941 unauthorized Taiwanese adults employed between 2008 and 2015 in the Taiwan Biobank project.…”

Section: Introductionmentioning

confidence: 99%

“…Exposure to PM 2.5 at concentrations above 38.98 µg/m 3 increases the susceptibility to COPD in Taiwanese non-smokers. Conflict with COPD involves combining tobacco control and pollution management strategies (11).…”

Section: Introductionmentioning

confidence: 99%

Estimation of PM2.5 Pollutant and Risk of Chronic Obstructive Pulmonary Disease (COPD) in Ahvaz, Iran

Zallaghi

Goudarzi

Sabzalipour

et al. 2020

Jundishapur J Chronic Dis Care

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Background: Urban air pollution was known to be one of the most important environmental problems due to its serious impact on human and environmental health. Among air pollutants, PM2.5 was the most common pollutant emitted by vehicles and dust and had negative consequences for human health, including chronic obstructive pulmonary disease (COPD). Objectives: This study aimed to assess the change levels of PM2.5 pollutants and their effect on COPD outcomes in ten years (2008 - 2017) in Ahvaz. Methods: Data were taken from the Ahvaz Department of Environment (ADoE). Data validation was performed using WHO criteria. The average time of PM2.5 was computed, and its health effects were obtained by entering its annual data and population at risk, baseline incidence (BI), and relative risk index for COPD outcomes in AirQ + software. The PM2.5 concentration average in total time changes in Ahvaz city was higher than the standard concentration set by WHO. The AQI index indicated that the city of Ahvaz did not have a good day in total during the ten-year time. Results: The result of time changes and AQI index indicated that 2010 was the most polluted year with 47 unhealthy days and 27 dangerous days. Also, with the enhancement in the PM2.5 annual concentrations, the mortality attributed to this pollution has increased as a consequence of the COPD outcome. The highest and lowest average cases COPD were 24 people in 2010 and 18 people in 2014, respectively. Conclusions: According to the results of this study, the air quality of Ahvaz city was in an unfavorable condition in terms of PM2.5 pollutions and the authorities should take the necessary measures to control and reduce pollution in the metropolis of Ahvaz for PM2.5 and reduce the mortality for the COPD health outcome.

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Association between chronic obstructive pulmonary disease and PM2.5 in Taiwanese nonsmokers

Cited by 40 publications

References 24 publications

More to Explore: Further Definition of Risk Factors for COPD – Differential Gender Difference, Modest Elevation in PM2.5, and e-Cigarette Use

More to Explore: Further Definition of Risk Factors for COPD – Differential Gender Difference, Modest Elevation in PM2.5, and e-Cigarette Use

Short-Term Effects of Particulate Matter and Its Constituents on Emergency Room Visits for Chronic Obstructive Pulmonary Disease: A Time-Stratified Case-Crossover Study in an Urban Area

Estimation of PM2.5 Pollutant and Risk of Chronic Obstructive Pulmonary Disease (COPD) in Ahvaz, Iran

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