Association between cingulum bundle structure and cognitive performance: An observational study in major depression

Schermuly, Ingrid; Fellgiebel, Andreas; Wagner, Stefanie; Yakushev, Igor; Stoeter, P.; Schmitt, Roland; Knickenberg, Rudolf J.; Bleichner, Franz; Beutel, Manfred E.

doi:10.1016/j.eurpsy.2010.05.001

Cited by 60 publications

(46 citation statements)

References 36 publications

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“…24 Besides the association of the cingulate cortices, cingulum fibers connect the middorsolateral frontal cortex with retrosplenial and parietal cortices, thalamus, hippocampus, and parahippocampal gyrus, and they have been suggested to be involved in executive functioning. 25 With respect to memory performance, the association between verbal learning and memory test scores and fornix MD and FA values is well established and has been documented in DT MR imaging studies of patients with other neurodegenerative and psychiatric diseases. 26,27 On the contrary, the relationship between visuospatial abilities and left uncinate FA is unexpected and should be interpreted with caution.…”

Section: Discussionmentioning

confidence: 97%

Cognitive Functions and White Matter Tract Damage in Amyotrophic Lateral Sclerosis: A Diffusion Tensor Tractography Study

Sarro

Agosta

Canu

et al. 2011

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 97%

Cognitive Functions and White Matter Tract Damage in Amyotrophic Lateral Sclerosis: A Diffusion Tensor Tractography Study

Sarro

Agosta

Canu

et al. 2011

AJNR Am J Neuroradiol

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“…Numerous cognitive processes that engage the hippocampus and ACC may be affected by compromised PC integrity. Earlier studies have shown that PC integrity corresponds significantly with verbal (Delano-Wood et al, 2012) and visual memory abilities (Kantarci et al, 2011), as well as executive processes (Schermuly et al, 2010) such as the suppression of pre-potent response, as required by the Stroop task (Metzler-Baddeley et al, 2012). Notably, impairments in these processes characterize anxious individuals (Bremner et al, 2004;Gilbertson et al, 2001;Vasterling et al, 1998;Vasterling et al, 2002;Yehuda et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

“…Disruptions in this region are likely to adversely influence both affective and cognitive processes. Regarding cognition, degraded PC microarchitecture has been linked to Alzheimer's disease (Zhang et al, 2007), mild cognitive impairment (Delano-Wood et al, 2012;Drago et al, 2011), and poorer performance on measures of selective attention, executive function (Schermuly et al, 2010), and memory (delayed recall; Kantarci et al, 2011), illustrating the salience of PC integrity in higher-order executive processes. Taken together, these findings suggest that PC disruptions have consequences for processing of incoming emotional and cognitive information.…”

Section: Introductionmentioning

confidence: 99%

“…In particular, structural abnormalities in posterior aspects of the cingulum (PC), assayed with DTI, may promote emotional disturbance; these abnormalities have been highlighted in DTI studies of psychiatric disorders, including schizophrenia (Chen et al, 2013;Fujiwara et al, 2007), anorexia (Kazlouski et al, 2011), depression (Schermuly et al, 2010), bipolar disorder (Paillere Martinot et al, 2013), and post-traumatic stress disorder (PTSD; Fani et al, 2012). Abnormalities in PC integrity have also been identified in traumatized populations, including individuals who experienced childhood abuse (Choi et al, 2009), natural disasters (Wang et al, 2010), and interpersonal trauma (Fani et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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FKBP5 Genotype and Structural Integrity of the Posterior Cingulum

Fani

King

Reiser

et al. 2013

Neuropsychopharmacol

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Alterations in the microarchitecture of the posterior cingulum (PC), a white matter tract proximal to the hippocampus that facilitates communication between the entorhinal and cingulate cortices, have been observed in individuals with psychiatric disorders, such as depression and post-traumatic stress disorder (PTSD). PC decrements may be a heritable source of vulnerability for the development of affective disorders; however, genetic substrates for these white matter abnormalities have not been identified. The FKBP5 gene product modulates glucocorticoid receptor function and has been previously associated with differential hippocampal structure, function, and affect disorder risk. Thus, FKBP5 is an attractive genetic target for investigations of PC integrity. We examined associations between PC integrity, measured through diffusion tensor imaging (DTI) and fractional anisotropy (FA; an index of white matter integrity), and polymorphisms in the FKBP5 SNP rs1360780 in a sample of 82 traumatized female civilians. Findings indicated that, compared with individuals without this allele, individuals who carried two 'risk' alleles for this FKBP5 SNP (T allele; previously associated with mood and anxiety disorder risk) demonstrated significantly lower FA in the left PC, even after statistically controlling for variance associated with age, trauma exposure, and PTSD symptoms. These data suggest that specific allelic variants for an FKBP5 polymorphism are associated with decrements in the left PC microarchitecture. These white matter abnormalities may be a heritable biological marker that indicates increased vulnerability for the development of psychiatric disorders, such as PTSD.

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“…Hippocampal dysfunction and atrophy associates with mood disorders (Small et al, 2011), and in normal and neurodegenerative conditions, DTI measures of WM microstrucure of the hippocampal part of the cingulum bundle correlate with memory scores and hippocampal volume (Sexton et al, 2010). The cingulum bundle integrates disparate modular brain systems involved in attention, memory, and emotion regulation, and in mood disorders, a higher directionality of water diffusion in the cingulum bundle associates with better hedonic tone (Keedwell et al, 2012), better cognitive performance (Schermuly et al, 2010), and less psychomotor slowing (Walther et al, 2012). The number of fibers within the uncinate fasciculus inversely correlated with depression severity (Zhang et al, 2012).…”

Section: Lithium and Gsk3-b Effects On White Matter F Benedetti Et Almentioning

confidence: 99%

Lithium and GSK3-β Promoter Gene Variants Influence White Matter Microstructure in Bipolar Disorder

Benedetti

Bollettini

Barberi

et al. 2012

Neuropsychopharmacol

147

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Lithium is the mainstay for the treatment of bipolar disorder (BD) and inhibits glycogen synthase kinase 3-b (GSK3-b). The less active GSK3-b promoter gene variants have been associated with less detrimental clinical features of BD. GSK3-b gene variants and lithium can influence brain gray matter structure in psychiatric conditions. Diffusion tensor imaging (DTI) measures of white matter (WM) integrity showed widespred disruption of WM structure in BD. In a sample of 70 patients affected by a major depressive episode in course of BD, we investigated the effect of ongoing long-term lithium treatment and GSK3-b promoter rs334558 polymorphism on WM microstructure, using DTI and tract-based spatial statistics with threshold-free cluster enhancement. We report that the less active GSK3-b rs334558*C gene-promoter variants, and the long-term administration of the GSK3-b inhibitor lithium, were associated with increases of DTI measures of axial diffusivity (AD) in several WM fiber tracts, including corpus callosum, forceps major, anterior and posterior cingulum bundle (bilaterally including its hippocampal part), left superior and inferior longitudinal fasciculus, left inferior fronto-occipital fasciculus, left posterior thalamic radiation, bilateral superior and posterior corona radiata, and bilateral corticospinal tract. AD reflects the integrity of axons and myelin sheaths. We suggest that GSK3-b inhibition and lithium could counteract the detrimental influences of BD on WM structure, with specific benefits resulting from effects on specific WM tracts contributing to the functional integrity of the brain and involving interhemispheric, limbic, and large frontal, parietal, and fronto-occipital connections.

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Association between cingulum bundle structure and cognitive performance: An observational study in major depression

Cited by 60 publications

References 36 publications

Cognitive Functions and White Matter Tract Damage in Amyotrophic Lateral Sclerosis: A Diffusion Tensor Tractography Study

Cognitive Functions and White Matter Tract Damage in Amyotrophic Lateral Sclerosis: A Diffusion Tensor Tractography Study

FKBP5 Genotype and Structural Integrity of the Posterior Cingulum

Lithium and GSK3-β Promoter Gene Variants Influence White Matter Microstructure in Bipolar Disorder

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