Association between circulating CD34-positive cells and serum alkaline phosphatase in relation to body mass index for elderly Japanese men

Abstract

BackgroundRecent studies have confirmed an association between bone metabolism and vascular homeostasis. However, no study has examined the relationship between serum alkaline phosphatase (ALP) (a marker of bone metabolism) and circulating immature cell such as CD34-positive cells (a marker of vascular homeostasis).MethodsWe conducted a cross-sectional study of this association in 272 elderly Japanese men (60–79 years). Because low body mass index (BMI) status is a known characteristic of Japanese with a high incidence rate of stroke, we used a stratified analysis based on BMI.ResultsMultivariable linear regression analysis adjusted for confounding factors showed a significant correlation between serum ALP and the number of circulating CD34-positive cells, especially for participants with low BMI (<23 kg/m2). The parameter estimates (β) and 95 % confidence intervals (CI) for one standard deviation increments in serum ALP levels (62 IU/L) for the circulating CD34-positive cell count were β = 0.25 (0.04, 0.45) for total subjects, β = 0.45 (0.16, 0.75) for participants with low BMI (<23 kg/m2), and β = 0.04 (−0.25, 0.34) for participants with high BMI (≥23 kg/m2).ConclusionSerum ALP correlates positively with circulating CD34-positive cells among a general population of elderly Japanese men, especially those with low BMI (<23 kg/m2). These findings suggest that serum ALP levels may constitute an efficient tool for estimating the risk of insufficient vascular homeostasis, especially for participants with relatively few classical cardiovascular risk factors.

Non-Linear Association Between Serum Alkaline Phosphatase and 3-Month Outcomes in Patients With Acute Stroke: Results From the Xi'an Stroke Registry Study of China

“…A reduction in CD34-positive cells has been approved to be related to increased infarction numbers (35). Studies have reported that ALP level was positively related to the number of CD34-positive cells, therefore we speculated that low ALP level may lead to an increased likelihood of poor outcomes by affecting the number of CD34-positive cells (35,36). Our results suggest that either higher or lower ALP levels are related to mortality and recurrence after stroke, providing new insight into the underlying mechanisms of the ALP impact on stroke outcomes.…”