Association between circulating full-length angiopoietin-like protein 8 and non-high-density lipoprotein cholesterol levels in Chinese non-diabetic individuals: a cross-sectional study

Yang, Song; Jiao, Xiaolu; Huo, Xiaoguang; Zhu, Miaomiao; Wang, Yi; Fang, Xiangnan; Yang, Yunyun; W, Yue; Qin, Yanwen

doi:10.1186/s12944-018-0802-9

Cited by 9 publications

(7 citation statements)

References 55 publications

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“…ANGPTL8 was also related to TG and CHOL in patients with hyperlipidemia after adjusting age, sex, BMI, alanine aminotransferase, hypersensitive C-reactive protein and CREA. In agreement to our findings on PNS patients, serum ANGPTL8 level was found to be positively associated with CHOL, but not with HDL-C and LDL-C [14].…”

Section: Hyperlipidemia Symptom Occurs In Pns Patients Involving Two supporting

confidence: 92%

“…Previous studies report ANGPTL8 detected both in human serum and mouse serum [9], as well as in human urine samplemoderates [10]. It's also recently observed that the serum levels of ANGPTL8 is significantly increased in patients with metabolic diseases such as type 2 diabetes [10,11], hyperlipidemia [12][13][14], non-alcoholic fatty liver [15] and so on. Moreover, in type 2 diabetes patients, the elevated serum ANGPTL8 level are associated with their increased risk of diabetic nephropathy, suggesting ANGPTL8's possible role in kidney damage [10].…”

Section: Introductionmentioning

confidence: 95%

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Serum and Urine ANGPTL8 Expression Levels are Associated with Hyperlipidemia and Proteinuria in Primary Nephrotic Syndrome

Gao

Liu

Kang

et al. 2020

Preprint

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Background: This study aimed to investigate the expression characteristics of ANGPTL8 in patients with primary nephrotic syndrome and its possible correlationwith hyperlipidemia and proteinuria.Methods: ANGPTL8 levels were determined using Enzyme‑linked immunosorbentassay in 133 subjects with PNS, and 60 subjects with healthy controls.Results: Subjects with primary nephrotic syndrome had higher levels of serum andurine ANGPTL8 than healthy controls subjects (P < 0.001). In primary nephroticsyndrome patients, serum ANGPTL8 was positively correlated with cholesterol (r =0.209, P < 0.05) and triglycerides (r = 0.412, P < 0.001), while no correlation with24hUTP. Urine ANGPTL8 was positively correlated with high density lipoprotein-cholesterol (r = 0.181, P < 0.05), while urine ANGPTL8 was significantly negativelycorrelated with creatinine (r = -0.323, P<0.001) and 24hUTP (r = -0.268, P = 0.002).Interestingly, urine ANGPTL8 concentrations were different between membranousnephropathy and mesangial proliferative glomerulonephritis pathological types.Conclusions: Serum and urine ANGPTL8 levels in primary nephrotic syndromepatients were correlated with blood lipid levels and proteinuria, respectively, suggestingthat ANGPTL8 may play a role in the development of primary nephrotic syndromehyperlipidemia and proteinuria.

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Section: Hyperlipidemia Symptom Occurs In Pns Patients Involving Two supporting

confidence: 92%

Section: Introductionmentioning

confidence: 95%

Serum and Urine ANGPTL8 Expression Levels are Associated with Hyperlipidemia and Proteinuria in Primary Nephrotic Syndrome

Gao

Liu

Kang

et al. 2020

Preprint

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“…Recent studies revealed an association between ANGPTL3 and ANGPTL8 with lipid biomarkers in adults, young obese non-diabetic men, children, and adolescents with obesity and metabolic syndrome. However, very few of them stratified their data by gender [5,6,[14][15][16]. We selected circulating ANGPTL3 and ANGPTL8 to assess gender-specific relationships with obesity and biomarkers of atherogenic lipid profile in non-diabetic adults aged between 25 and 74 years.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Serum Angiopoietin-like Proteins 3 and 8 and Atherogenic Lipid Biomarkers in Non-Diabetic Adults Depends on Gender and Obesity

et al. 2021

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Hypertriglyceridemia is an independent risk factor for coronary artery disease. Lipoprotein lipase (LPL) plays an essential role in the metabolism of triglyceride-rich lipoproteins (TRLs). Angiopoietin-like proteins ANGPTL3 and ANGPTL8 are shown to be important regulators of LPL activity. Increased concentrations of these proteins may reflect cardiovascular risk, and the treatment of patients with dyslipidemia with ANGPTLs inhibitors may decrease this risk. We assessed the gender-specific relationships of serum ANGPTL3 and ANGPTL8 with atherogenic lipid biomarkers and obesity in non-diabetic adults. The study comprised 238 participants aged 25–74 [122 with triglycerides (TG) <150 mg/dL (<1.7 mmol/L) and 116 with hypertriglyceridemia]. Total cholesterol, HDL-cholesterol, LDL-cholesterol, TG, C-reactive protein (CRP), glycated hemoglobin, apolipoprotein B, small dense LDL-C (sd-LDL-C), ANGPTL3, and ANGPTL8 were measured. Non-HDL-cholesterol, remnant cholesterol (remnant-C) concentrations, and body mass index (BMI) were calculated. Results: Women and men did not differ in terms of age, CRP levels, the percentage of obese subjects, and concentrations of atherogenic lipid biomarkers, except higher TG in males and higher ANGPTL3 concentrations in females. Positive correlations of both ANGPTLs with TG, remnant-C, and sdLDL-C levels were found in females. In males, only ANGPTL3 correlated positively with atherogenic biomarkers, but there were no correlations with ANGPTL8. Concentrations of ANGPTL3 were higher in obese men, whereas ANGPTL8 levels were higher in obese women. In women alone, ANGPTL8 showed very good discrimination power to identify subjects with hypertriglyceridemia (AUC = 0.83). Contrary to this, ANGPTL3 was a better discriminator of hypertriglyceridemia (AUC = 0.78) in male subjects. Regression models, adjusted for age, sex, and BMI showed a weak but significant effect of ANGPTL8 to increase the risk of hypertriglyceridemia. Conclusions: In females, ANGPTL8 is more strongly associated with TRLs metabolism, whereas in males, ANGPTL3 plays a more important role. We suggest sex differences be taken into consideration when applying new therapies with angiopoietin-like proteins inhibitors in the treatment of dyslipidemia.

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“…*P < 0.05 were adjusted in logistic regression in this study. ANGPTL8 was also reported to be negatively associated with HDL-C levels [42], while multiple logistic regression analysis showed that ANGPTL8 was associated with TAD after adjusting for HDL-C. Numerous studies have demonstrated that ANGPTL8 levels are positively correlated with FPG and insulin resistance [43].…”

Section: Discussionmentioning

confidence: 99%

Increased Circulating Angiopoietin-Like Protein 8 Levels Are Associated with Thoracic Aortic Dissection and Higher Inflammatory Conditions

Yang

Jiao

et al. 2020

Cardiovasc Drugs Ther

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Purpose Thoracic aortic dissection (TAD) is characterized by an inflammatory response. Angiopoietin-like protein 8 (ANGPTL8) is a hormone involved in the regulation of lipid metabolism and inflammation. However, the relationship between ANGPTL8 and TAD remains unknown. Methods This case-control study included 78 TAD patients and 72 controls. The aortic diameter was evaluated by computed tomography and used to assess TAD severity. Circulating ANGPTL8 levels were measured by enzyme-linked immunosorbent assay. Associations of ANGPTL8 with TAD were determined by multivariate logistic regression. Results Serum ANGPTL8 levels were significantly higher in TAD patients compared with controls (562.50 ± 20.84 vs. 419.70 ± 22.65 pg/mL, respectively; P < 0.001). After adjusting for confounding factors, circulating ANGPTL8 levels were an independent risk factor for TAD (odds ratio = 1.587/100 pg ANGPTL8, 95% confidence interval [CI] = 1.121–2.247, P < 0.001) and positively associated with diameter (β = 1.081/100 pg ANGPTL8, 95% CI = 0.075–2.086, P = 0.035) and high-sensitivity C-reactive protein (hs-CRP) (β = 0.845/100 pg ANGPTL8, 95% CI = 0.020–1.480, P = 0.009). The area under the curve (AUC) on receiver operating characteristic (ROC) analysis of the combination of ANGPTL8, hs-CRP, and D-dimer was 0.927, and the specificity and sensitivity were 98.46% and 79.49%, respectively. ANGPTL8 was significantly increased in TAD tissue compared with controls. In vitro, ANGPTL8 was increased in angiotensin II (AngII)-treated macrophages and vascular smooth muscle cells (VSMCs), while ANGPTL8 siRNA-mediated knockdown decreased inflammatory factors in AngII-treated macrophages and decreased apoptosis in AngII-treated VSMCs. Conclusion ANGPTL8 is associated with TAD occurrence and development, which may involve pro-inflammatory effects on macrophages. ANGPTL8 combined with D-dimer and hs-CRP might be a useful clinical predictor of TAD. Trial Registration ChiCTR-COC-17010792 http://www.chictr.org.cn/showproj.aspx?proj=18288

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Association between circulating full-length angiopoietin-like protein 8 and non-high-density lipoprotein cholesterol levels in Chinese non-diabetic individuals: a cross-sectional study

Cited by 9 publications

References 55 publications

Serum and Urine ANGPTL8 Expression Levels are Associated with Hyperlipidemia and Proteinuria in Primary Nephrotic Syndrome

Serum and Urine ANGPTL8 Expression Levels are Associated with Hyperlipidemia and Proteinuria in Primary Nephrotic Syndrome

Relationship between Serum Angiopoietin-like Proteins 3 and 8 and Atherogenic Lipid Biomarkers in Non-Diabetic Adults Depends on Gender and Obesity

Increased Circulating Angiopoietin-Like Protein 8 Levels Are Associated with Thoracic Aortic Dissection and Higher Inflammatory Conditions

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