Association between circulating leptin concentration and G-2548A gene polymorphism in patients with breast cancer: a meta-analysis

Hao, Jing; Zhang, Qiankun; Zhou, Yixin; Chen, Li-Hao; Wu, Pengfei

doi:10.5114/aoms.2018.75638

Cited by 17 publications

(12 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, Ben et al [49] reported that LEPR rs1137101 G>A SNP may affect plasma LEP levels and BMI. A previous study suggested that leptin level was associated with the development of breast cancer [50]. However, null associations of LEPR rs1137101 locus with cancer susceptibility was identified, which was analogous to the results reported in previous meta-analyses [9,10,51,52], but unlike the other four meta-analyses [48,53–55].…”

Section: Discussionsupporting

confidence: 85%

Investigation ofleptin receptorrs1137101 G>A polymorphism with cancer risk: evidence from 35936 subjects

Rong

Tang

Wang³

et al. 2019

Bioscience Reports

View full text Add to dashboard Cite

Leptin receptor (LEPR) signaling may be involved in promoting angiogenesis and proliferation, inhibiting apoptosis and playing a vital role in the progression of carcinogenesis. A number of studies have focused on the association of LEPR rs1137101 variants with susceptibility of cancer, however, the observed results were controversial. We searched literature on the relationship of LEPR rs1137101 G>A polymorphism with cancer risk by using PubMed and Embase databases, covering all publications up to 14 October 2018. In total, 44 case–control studies with 35,936 subjects were included. After combining all eligible studies, we identified null relationship between LEPR gene rs1137101 G>A polymorphism and overall cancer risk [A vs. G: odds ratio (OR ) = 0.97, 95% confidence interval (CI ) = 0.89–1.06, P = 0.547; AA vs. GG: OR = 0.93, 95% CI = 0.78–1.13, P = 0.476; AA/GA vs. GG: OR = 0.99, 95% CI = 0.91–1.09, P= 0.890 and AA vs. GA/GG: OR = 0.92, 95% CI = 0.82–1.04, P= 0.198]. However, in a subgroup analysis, there was an increased susceptibility of oral and oropharyngeal cancer in AA vs. GA/GG genetic model (OR, 1.83; 95% CI, 1.01–3.33; P=0.048). Considering the limited participants were included, the findings might be underpowered. Sensitivity analysis identified that any independent study omitted did not materially influence the pooled ORs and CIs. The results of publication bias detection showed that there was no evidence of bias. In summary, this analysis indicates that no significant association of cancer risk was identified to be correlated with rs1137101 G>A variants, even in stratified analyses.

show abstract

Section: Discussionsupporting

confidence: 85%

Investigation ofleptin receptorrs1137101 G>A polymorphism with cancer risk: evidence from 35936 subjects

Rong

Tang

Wang³

et al. 2019

Bioscience Reports

View full text Add to dashboard Cite

show abstract

“…The pathogenesis of disease involves many factors, such as genes, infections, environment and nutrition supplementation [77][78][79][80][81][82][83][84][85], which regulates the metabolism of some molecules, thus resulting in the diseases [86,87]. GDM is a well-known complication with high prevalence ternal glycemia, and high risk of GDM.…”

Section: Discussionmentioning

confidence: 99%

Serum vitamin D deficiency and risk of gestational diabetes mellitus: a meta-analysis

Wang¹,

Zhang²,

Song³

et al. 2020

aoms

View full text Add to dashboard Cite

Introduction: This meta-analysis was performed to confirm the relationship of gestational diabetes mellitus (GDM) and vitamin D. Material and methods: PubMed and CNKI databases were searched for relevant articles. Standard mean difference (SMD) along with 95% CI was used to compare vitamin D level between women with GDM and healthy subjects. The correlation coefficient between the vitamin D and homeostasis model assessment-insulin resistance index (HOMA-IR) was analyzed. Results: The vitamin D level of GDM subjects was much lower than healthy subjects (SMD =-0.71, 95% CI:-0.91,-0.50). Vitamin D deficiency was associated with high risk of GDM (OR = 1.15, 95% CI: 1.07-1.23). Vitamin D was negatively correlated with HOMA-IR (r =-0.62, 95% CI:-0.85,-0.39). The analysis showed no publication bias (Egger's: p = 0.197; Begg's: p = 0.786). Conclusions: Vitamin D is closely associated with the onset of GDM.

show abstract

“…82 Females with elevated serum leptin have higher breast cancer risk. 83,84 A meta-analysis of 43 studies suggests that the serum leptin may provoke a major role in the pathogenesis and metastasis of breast cancer. 78 Another meta-analysis of 23 reports 85 showed that circulating leptin levels among healthy people were less than patients with breast benign disease, less than patients with breast cancer, and less than lymph node metastasis-positive patients, signifying leptin levels as a suitable diagnostic tool for neoplasia.…”

Section: The Link Between Leptin and Breast Cancermentioning

confidence: 99%

Linkage Between Obesity Leptin and Breast Cancer

Atoum

Alzoughool

Al-Hourani

2020

Breast Cancer�(Auckl)

View full text Add to dashboard Cite

Many cancers might be influenced by obesity, including breast cancer, the leading cause of cancer death among women. Obesity is a complex state associated with multiple physiological and molecular changes capable of modulating the behavior of breast tumor cells and the surrounding microenvironment. This review discussed the inverse association between obesity and breast cancer among premenopausal breast cancer females and the positive association among postmenopausal. Four mechanisms may link obesity and breast cancer including leptin and leptin receptor expression, adipose chronic inflammation, sex hormone alternation, and insulin and insulinlike growth factor 1 (IGF-1) signaling. Leptin has been involved in breast cancer initiation, development, and progression through signaling transduction network. Leptin functions are strengthened through cross talk with multiple oncogenes, cytokines, and growth factors. Adipose chronic inflammation promotes cancer growth and angiogenesis and modifies the immune responses. A pro-inflammatory microenvironment at tumor site promotes cytokines and pro-inflammatory mediators adjacent to the tumor. Leptin stimulates pro-inflammatory cytokines and promotes T-helper 1 responses. Obesity is common of chronic inflammation. In obese patients, white adipose tissue (WAT) will promote pro-inflammatory mediators that will encourage tumor growth and WAT inflammation. Sex hormone alternation of estrogens is associated with increased risk for hormone-sensitive breast cancers. Estrogens cause tumorigenesis by its effect on signaling pathways that lead to DNA damage, stimulation angiogenesis, mutagenesis, and cell proliferation. In postmenopausal females, and due to termination of ovarian function, estrogens were produced extra gonadally, mainly in peripheral adipose tissues where adrenal-produced androgen precursors are converted to estrogens. Active estradiol leads to breast cancer development by binding to ERα, which is modified by receptor’s interaction of various signal transduction pathways. Hyperinsulinemia and IGF-1 activate the MAPK and PI3K pathways, leading to cancer-promoting effects. Cross talk between insulin/IGF and estrogen signaling pathways promotes hormone-sensitive breast cancer development. Hyperinsulinemia is a risk factor for breast cancer that explains the obesity-breast cancer association. Controlling IGF-1 level and targeting IGF-1 receptors among different breast cancer subtypes may be useful for breast cancer treatment. This review discussed several leptin signaling pathways, highlighting the potential advantage of targeting leptin as a potential target of the novel therapeutic strategies for breast cancer treatment.

show abstract

Association between circulating leptin concentration and G-2548A gene polymorphism in patients with breast cancer: a meta-analysis

Cited by 17 publications

References 43 publications

Investigation ofleptin receptorrs1137101 G>A polymorphism with cancer risk: evidence from 35936 subjects

Investigation ofleptin receptorrs1137101 G>A polymorphism with cancer risk: evidence from 35936 subjects

Serum vitamin D deficiency and risk of gestational diabetes mellitus: a meta-analysis

Linkage Between Obesity Leptin and Breast Cancer

Contact Info

Product

Resources

About

Association between circulating leptin concentration and G-2548A gene polymorphism in patients with breast cancer: a meta-analysis

Cited by 17 publications

References 43 publications

Investigation ofleptin receptorrs1137101 G&gt;A polymorphism with cancer risk: evidence from 35936 subjects

Investigation ofleptin receptorrs1137101 G&gt;A polymorphism with cancer risk: evidence from 35936 subjects

Serum vitamin D deficiency and risk of gestational diabetes mellitus: a meta-analysis

Linkage Between Obesity Leptin and Breast Cancer

Contact Info

Product

Resources

About

Investigation ofleptin receptorrs1137101 G>A polymorphism with cancer risk: evidence from 35936 subjects

Investigation ofleptin receptorrs1137101 G>A polymorphism with cancer risk: evidence from 35936 subjects