Association between clinical and sonographic synovitis in patients with painful knee osteoarthritis

Abbasi, Bita; Pezeshki-Rad, Masoud; Akhavan, Reza; Sahebari, Maryam

doi:10.1111/1756-185x.12834

Cited by 19 publications

(11 citation statements)

References 11 publications

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“…The questionnaire we used is a useful tool to diagnose OA, including in the very early stages, and it also helps determine the severity of synovitis, which is an important finding in knee OA. 19,26,27 Thanks to this questionnaire, we believe we were able to obtain a reasonable assessment of the extent of OA in each participant, including those in the very early stages and those who would not have shown changes on radiographic imaging.…”

Section: Discussionmentioning

confidence: 99%

Association Between Knee Pain, Impaired Function, and Development of Depressive Symptoms

Sugai

Takeda-Imai

Michikawa

et al. 2018

J American Geriatrics Society

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Section: Discussionmentioning

confidence: 99%

Association Between Knee Pain, Impaired Function, and Development of Depressive Symptoms

Sugai

Takeda-Imai

Michikawa

et al. 2018

J American Geriatrics Society

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“…More than 2 years before onset, patients with AKOA present with more pain, synovitis-effusion of larger volumes and signal alterations in the infrapatellar fat pad (IFP) compared with patients who develop typical knee OA 17,18 . MRI and ultrasonography have also been used to evaluate associations between synovitis and pain 5,[19][20][21][22][23][24][25][26][27] , finding that synovitis contributes to pain in OA. Of note, a study found that synovitis partially mediates the association between cartilage damage loss and worsening pain: each 0.1-mm loss of cartilage over 24 months translated to an increase in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale score of 0.32 (95% CI 0.21-0.44) 28 .…”

mentioning

confidence: 99%

Synovial inflammation in osteoarthritis progression

et al. 2022

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Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration. Synovial inflammation is present in the OA joint and has been associated with radiographic and pain progression. Several OA risk factors, including ageing, obesity, trauma and mechanical loading, play a role in OA pathogenesis, likely by modifying synovial biology. In addition, other factors, such as mitochondrial dysfunction, damage-associated molecular patterns, cytokines, metabolites and crystals in the synovium, activate synovial cells and mediate synovial inflammation. An understanding of the activated pathways that are involved in OA-related synovial inflammation could form the basis for the stratification of patients and the development of novel therapeutics. This Review focuses on the biology of the OA synovium, how the cells residing in or recruited to the synovium interact with each other, how they become activated, how they contribute to OA progression and their interplay with other joint structures.

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“…In patients with OA, synovial tissue affected by fibrosis becomes thicker and rigid [30]. These symptoms contribute to the main characteristics of OA, such as joint pain and stiffness [57]. Fibrosis results in fibrin deposition in the synovial tissue [58].…”

Section: Synovial Fibrosis In Oamentioning

confidence: 99%

The Role of Fibrosis in Osteoarthritis Progression

Rim

2020

Life

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Osteoarthritis (OA) is a chronic degenerative joint disease where the main characteristics include cartilage degeneration and synovial membrane inflammation. These changes in the knee joint eventually dampen the function of the joint and restrict joint movement, which eventually leads to a stage where total joint replacement is the only treatment option. While much is still unknown about the pathogenesis and progression mechanism of OA, joint fibrosis can be a critical issue for better understanding this disease. Synovial fibrosis and the generation of fibrocartilage are the two main fibrosis-related characteristics that can be found in OA. However, these two processes remain mostly misunderstood. In this review, we focus on the fibrosis process in OA, especially in the cartilage and the synovium tissue, which are the main tissues involved in OA.

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Association between clinical and sonographic synovitis in patients with painful knee osteoarthritis

Abstract: This study revealed a positive correlation between ultrasonographic synovitis and total WOMAC score, WOMAC pain and physical function sub-score. There was no association between sonographic signs of arthritis and WOMAC joint stiffness sub-score.

Cited by 19 publications

References 11 publications

Association Between Knee Pain, Impaired Function, and Development of Depressive Symptoms

Association Between Knee Pain, Impaired Function, and Development of Depressive Symptoms

Synovial inflammation in osteoarthritis progression

The Role of Fibrosis in Osteoarthritis Progression

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