Association between Clinical Malaria and Blood Lipids in North Eastern India

Warjri, Synrang Batngen; Ete, Tony; Mishra, Alok; Barman, Bhupen; Mishra, Jaya; Pala, Star; Beyong, Taso; Issar, Neel Kanth

doi:10.9734/bjmmr/2016/23751

Cited by 5 publications

(7 citation statements)

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“…Total cholesterol and LDL levels of the study participants were within the normal reference ranges (<100 and <200), respectively, before antimalarial treatment was administered. The finding of the present study agreed with a previous study finding conducted in Ethiopia where LDL (34.7±23.5) and TC(88.0±36.3) levels were reported (36) and a similar result from India reported a value of LDL(70.45±22.720) and TC(103.52±35), respectively (33).On the other hand, our study findings are lower than the study conducted in Brazil where TG (55.8%),HDL (92.8%), and LDL (97.6%) levels were reported (37). The possible explanation of the difference in liver enzymes and lipid profiles could be due to the utilization of different cutoff values, malaria species, or the difference of study participants in sociodemographic characteristics such as age and genetic variation.…”

Section: Serum Liver Enzymes and Lipid Profiles In Different Level Of...supporting

confidence: 93%

“…Besides, serum ALT concentration was determined by the pyruvate method while AST concentration was measured using the oxaloacetate method. Serum HDL, total cholesterol, LDL, and triglycerides were measured by the enzymatic assay method (32)(33)(34).The interpretation of test results was based on the manufacturers manual for each analysis to be measured. The enzymes and lipid profiles were done at the University of Gondar compressive specialized hospital laboratory…”

Section: Blood Sample Collection and Processingmentioning

confidence: 99%

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Liver enzymes and lipid profile of malaria patients before and after antimalarial drug treatment at Dembia Primary Hospital and Teda Health Center, Northwest, Ethiopia

Megabiaw

Eshetu

Kassahun

et al. 2021

Preprint

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Backgroundinfection with malaria in humans involves liver cell destruction, which alters the levels of liver enzymes and lipid profiles. Although a number of studies have been conducted to address the impact of malaria on liver enzymes and lipid profiles, their findings lack consistency and no studies were conducted after antimalarial drug treatment in the Ethiopian context. This study, therefore, is intended to fill this gap. MethodsAn observational cohort study was conducted at Dembia Primary Hospital and Teda Health Center, from June to August 2020. A total of 88 study participants were recruited using random sampling techniques. Socio-demographic data, capillary and venous blood samples were collected from confirmed Plasmodium -infected individuals. Assessment of liver enzymes and lipid profiles was done using Beckman Coulter DC-700 clinical chemistry analyzer. Data were entered using Epi-data and exported to SPSS version 20 software for analysis. One way ANova, independent t-test, and paired t-test were used to compare the mean liver enzymes and lipid profile. A p -value<0.05 was considered statistically significant. RESULTSBefore anti-malaria treatment, among 88 malaria-infected study participants, abnormally elevated AST was observed in 87.5% of them. Similarly, elevated ALT, ALP, and TG were observed among 12.5%, 43.2%, and 17.2% of the study subjects, respectively. A lower level of HDL was observed among 87.5% of the study participants, while LDL and TC levels were within the normal range. After anti-malaria treatment,100% of AST, ALT, HDL, and LDL, and 92% of ALP, 94.3% of TC, and 86.4% of TG results were in the normal range. The mean level of AST (39.70±3.55and 55.35±9.6) and ALT (22.11±11.75, and23.24±16.05) results were increased, whereas HDL (28.88±11.63and22.73±14.26) level decreased from low to higher density parasitaemia. The mean level of AST at posttreatment (33.90±15.15) was significantly lower compared to the pretreatment (47.60±9.65). The mean levels of ALT had not altered during pretreatment(23.53±16.28)and posttreatment (23.49±11.10).Moreover, the mean of HDL, LDL, and TC at posttreatment were found to be increased when compared with pretreatment, though it is statistically insignificant ( P >0.05). CONCLUSIONMalaria parasites could be responsible for increased liver enzymes and certain lipids while decreasing some lipid profiles compared with the normal range. After anti-malaria treatment, these parameters were reversed to normal from 86.4% to 100%. When the mean values are compared, a significant change was observed in AST level while ALT level remains the same. Hence, prompt treatment is important to improve liver enzymes and lipid profile impairment during malaria infection.

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Section: Serum Liver Enzymes and Lipid Profiles In Different Level Of...supporting

confidence: 93%

Section: Blood Sample Collection and Processingmentioning

confidence: 99%

Liver enzymes and lipid profile of malaria patients before and after antimalarial drug treatment at Dembia Primary Hospital and Teda Health Center, Northwest, Ethiopia

Megabiaw

Eshetu

Kassahun

et al. 2021

Preprint

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“…Serum HDL, total cholesterol, LDL, and triglycerides were measured by the enzymatic assay method. [37][38][39] The interpretation of test results was based on the manufacturers manual for each analysis to be measured. The enzymes and lipid profiles were done at the University of Gondar compressive specialized hospital laboratory.…”

Section: Blood Sample Collection and Processingmentioning

confidence: 99%

Liver Enzymes and Lipid Profile of Malaria Patients Before and After Antimalarial Drug Treatment at Dembia Primary Hospital and Teda Health Center, Northwest, Ethiopia

Megabiaw¹,

Eshetu²,

Kassahun³

et al. 2022

RRTM

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Background: Infection with malaria in humans involves liver cell destruction, which alters the levels of liver enzymes and lipid profiles. A number of studies have been conducted to address the impact of malaria on liver enzymes and lipid profiles but no studies were addressed after antimalarial treatment in Ethiopia. This study is intended to fill this gap. Methods: An observational cohort study was conducted at Dembia Primary Hospital and Teda Health Center, from June to August 2020. Eighty eight malaria infected study participants were recruited using random sampling techniques. Sociodemographic data, capillary and venous blood samples were collected. Assessment of liver enzymes and lipid profiles was done using Beckman Coulter DC-700 clinical chemistry analyzer. Data were entered using Epi-data and exported to SPSS version 20 for analysis. One way ANOVA, independent t-test, and paired t-test were used to compare the mean liver enzymes and lipid profile. p-value<0.05 was considered statistically significant. Results: Before anti-malaria treatment, among 88 study participants, elevated AST (87.5%), ALT (12.5%), ALP (43.2%), and TG (17.2%) and lower HDL (87.5%) and normal LDL and TC were observed. After treatment, 100% AST, ALT, HDL, and LDL and 92% ALP, 94.3% TC, and 86.4% TG levels were in the normal range. The mean level of AST and ALT increased while HDL decreased from low to higher density parasitaemia. Mean level of AST was significantly lower while ALT did not alter. HDL, LDL, and TC level were increased but statistically were insignificant (P>0.05). Conclusion: Malaria could be responsible for increased liver enzymes and certain lipids while decreasing some lipid profiles. After anti-malaria treatment, these parameters were reversed to normal from 86.4% to 100%. Hence, prompt treatment is important to improve liver enzymes and lipid profile impairment during malaria infection.

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“…North East India bears a large case burden of malaria in India and is co-endemic for both P. falciparum and P. vivax malaria [17][18][19][20]. Vivax malaria has been reported in almost all states of North East India, attributing up to 60-80% of all malaria cases in some states [17].…”

Section: Discussionmentioning

confidence: 99%

Study of Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency and Genotype Polymorphism of G6PD B and G6PD (A+/A-) in Patients Treated for Plasmodium vivax Malaria in a Tertiary Care Hospital in North East India

Rajkhowa

Nath

Dutta³

et al. 2020

Cureus

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Introduction Glucose-6-phosphate dehydrogenase (G6PD) enzyme deficiency is the most common enzymopathy in humans, and its distribution has been historically described to be closely associated with that of malaria. North East India provides optimal conditions for transmission of malaria and bears a considerable burden of Plasmodium vivax ( P. vivax ) malaria. Primaquine, a mainstay in the treatment of vivax malaria, may trigger episodes of acute hemolysis in patients with G6PD deficiency. The present study sought to delineate the frequency and genotypes of G6PD deficiency among patients suffering from vivax malaria infections. Methods Blood specimens from 80 individuals diagnosed with vivax malaria underwent enzyme assay for G6PD deficiency. Samples with deficient phenotype underwent isolation of DNA using a genomic DNA isolation kit (Qiagen India Pvt. Ltd., New Delhi, India). The genomic DNA underwent amplification, serial denaturation, annealing, extension, final extension followed by digestion with restriction endonucleases Nla III and Fok I. The digested products were subjected to horizontal agarose electrophoresis for the separation of digested fragments. Samples without nucleotide 376 adenine→guanine (A→G) mutation were classified as G6PD B. Those with the mutation were further classified into G6PD A(+) and G6PD A(-) based on the presence of Nla III site. Results Twenty-seven out of 80 individuals (33.75%) with P. vivax malaria were found to have G6PD deficiency, of which a majority (n=24) had G6PD B genotype. Three individuals had Asparagine→Aspartic Acid mutation at position 376 (A→G), of which G6PD A(+) and G6PD A(-) were present in two and one cases, respectively. Conclusion G6PD deficiency was noted in about a third of patients with vivax malaria. Since primaquine therapy is contraindicated in this group of patients, there is a rationale for looking into screening patients with vivax malaria from the region prior to primaquine therapy. Further large scale studies may substantiate this and help in better genotypic and geographic characterization of G6PD deficiency in the region.

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Association between Clinical Malaria and Blood Lipids in North Eastern India

Cited by 5 publications

References 0 publications

Liver enzymes and lipid profile of malaria patients before and after antimalarial drug treatment at Dembia Primary Hospital and Teda Health Center, Northwest, Ethiopia

Liver enzymes and lipid profile of malaria patients before and after antimalarial drug treatment at Dembia Primary Hospital and Teda Health Center, Northwest, Ethiopia

Liver Enzymes and Lipid Profile of Malaria Patients Before and After Antimalarial Drug Treatment at Dembia Primary Hospital and Teda Health Center, Northwest, Ethiopia

Study of Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency and Genotype Polymorphism of G6PD B and G6PD (A+/A-) in Patients Treated for Plasmodium vivax Malaria in a Tertiary Care Hospital in North East India

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