Association between co-exposure to phenols, phthalates, and polycyclic aromatic hydrocarbons with the risk of frailty

Li, Wenxiang; Huang, Guangyi; Tang, Ningning; Lu, Peng; Jiang, Li; Lv, Jian; Qin, Yuanjun; Lin, Yunru; Xu, Fan; Lei, Daizai

doi:10.1007/s11356-023-29887-7

Cited by 2 publications

(1 citation statement)

References 51 publications

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“…Moreover, these accruing physical impairments further reduce the body’s resistance to external stresses, potentially heightening the risk of frailty [ 13 ], which in turn may precipitate a further decline in physical function and disease [ 14 ]. The positive association between exposure to phthalates and polycyclic aromatic hydrocarbons with frailty has been elucidated [ 15 ]. Nevertheless, the nature of the association between frailty and heavy metal exposure remains poorly understood.…”

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confidence: 99%

The association of urinary heavy metal exposure with frailty susceptibility and mortality in middle-aged and older adults: a population-based study

Zheng,

Luo,

Xue

2024

Arch Public Health

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Heavy metals’ presence as environmental pollutants has a close link to adverse health effects. Frailty, a clinical syndrome hallmarked by elevated vulnerability to stressors, presents a substantial challenge in healthcare. However, the association between exposure to heavy metals and frailty largely remains unexplored. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) spanning 2003–2018 and correlated with the U.S. National Death Index (NDI) from 2019, we investigated mortality outcomes. Logistic regression, Cox regression, Kaplan-Meier survival curves, weighted quantile-sum (WQS) regression, and Bayesian kernel machine regression (BKMR) were employed to assess the association between heavy metal exposure and frailty incidence and mortality in the frail population. Eight metals were measured in urine using inductively coupled plasma mass spectrometry with values adjusted for urinary creatinine, which was used to reflect heavy metal exposure. The cohort incorporated 5370 female participants aged 45 and above, with 1518 diagnosed with frailty. The findings indicated a substantial correlation between exposure to specific heavy metals, namely tungsten (odds ratio [OR]: 1.94, 95% confidence interval [CI]: 1.31–2.89), cobalt (OR: 1.64, 95% CI: 1.40–1.93), cadmium (OR: 1.93, 95% CI: 1.52–2.43), and uranium (OR: 7.36, 95% CI: 1.53–35.28), and an elevated risk of frailty. WQS and BKMR regression models identified cadmium, cobalt, and tungsten as main contributors to frailty. Cox regression analysis, after adjustment for covariates, suggested that the higher the exposure levels to cadmium and lead, the higher the risk of death in frail patients, with associated hazard ratios (HR) of 95% CI: 1.96 (1.53, 2.52) and 1.30 (1.13, 1.49), respectively. Our study revealed a significant positive correlation between exposure to heavy metal mixtures and frailty onset in middle-aged and older adults, along with increased mortality in frail patients. Cobalt, cadmium, and tungsten emerged as prominent contributors to frailty, with cobalt and cadmium directly impacting the long-term life expectancy of frail patients.

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Section: Introductionmentioning

confidence: 99%

The association of urinary heavy metal exposure with frailty susceptibility and mortality in middle-aged and older adults: a population-based study

Zheng,

Luo,

Xue

2024

Arch Public Health

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Associations between urinary phytoestrogen mixed metabolites and osteoarthritis risk

Huang,

Wang,

Wang

et al. 2024

PLoS ONE

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Background This study aims to explore the relationship between urinary phytoestrogen mixed metabolites and the risk of osteoarthritis (OA). Methods Using data from the National Health and Nutrition Examination Survey (NHANES), a Weighted Quantile Sum (WQS) regression analysis was conducted to determine the dominant metabolites. Additionally, a Bayesian kernel machine regression (BKMR) model was utilized to explore the combined effects of phytoestrogen mixed metabolites on OA. Results Compared to the lowest quartile group, the highest quartile group of Enterodiol showed a 46% increased risk of OA (OR = 1.46, 95% CI: 1.09–1.96), while the highest quartile group of Enterlactone showed a 30% decreased risk of OA (OR = 0.70, 95% CI: 0.52–0.96). The WQS regression model analysis revealed a positive relationship between urinary phytoestrogen mixed metabolites and OA risk, with Enterodiol found to have the highest weight in this association. The BKMR model indicated that the association between urinary phytoestrogens and OA increased with concentration but did not reach statistical significance. The univariate exposure-response function demonstrated a positive association between Enterodiol and OA. Conclusions There is a positive relationship between urinary phytoestrogen mixed metabolites and OA, with Enterodiol being an important factor influencing OA risk.

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Association between co-exposure to phenols, phthalates, and polycyclic aromatic hydrocarbons with the risk of frailty

Cited by 2 publications

References 51 publications

The association of urinary heavy metal exposure with frailty susceptibility and mortality in middle-aged and older adults: a population-based study

The association of urinary heavy metal exposure with frailty susceptibility and mortality in middle-aged and older adults: a population-based study

Associations between urinary phytoestrogen mixed metabolites and osteoarthritis risk

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