Association between co-inhibitory molecule gene tagging single nucleotide polymorphisms and the risk of colorectal cancer in Chinese

Ge, Jie; Zhu, Lin; Zhou, Jianqiu; Li, Guangxiao; Li, Ye; Li, Shuying; Wu, Zhiwei; Rong, Jiesheng; Yuan, Huiping; Liu, Yanhong; Chi, Qiang; Piao, Daxun; Zhao, Yong; Cui, Binbin

doi:10.1007/s00432-015-1915-4

Cited by 43 publications

(49 citation statements)

References 42 publications

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“…For rs231775, 64 studies involved a total of 23617 cases and 27261 controls [10-15, 17-73]. Moreover, there were 30 studies with 9675 cases and 9623 controls for rs3087243 [12-15, 17, 23-25, 27-29, 31, 32, 35, 37, 40, 41, 44, 45, 47, 53, 54, 61, 63, 65, 66, 73-75].…”

Section: Resultsmentioning

confidence: 99%

Association of Five Snps in Cytotoxic T-Lymphocyte Antigen 4 and Cancer Susceptibility: Evidence from 67 Studies

Fang

Huang

et al. 2018

Cell Physiol Biochem

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Background/Aims: CTLA-4 polymorphisms are associated with susceptibility to various cancers, but the results are often conflicting. Hence, we performed a comprehensive meta-analysis to quantitatively investigate the association between CTLA-4 polymorphisms (rs231775, rs4553808，rs5742909, rs3087243 or rs733618) and cancer risk. Methods: Data were collected from PubMed and Web of Science. A total of 67 case-control studies were selected for quantitative analysis. Stata (Version 12) software was used to calculate the odds ratio (OR) and 95% confidence interval (CI) to evaluate the strength of the associations. Subgroup meta-analysis was conducted based on ethnicity and cancer type. Heterogeneity tests, sensitivity analysis, and publication bias assessments were also performed. Results: rs231775, rs4553808 and rs5742909 but not rs3087243 and rs733618 were significantly related to cancer risk. In analyses stratified by ethnicity, both rs231775 and rs4553808 were significant susceptibility polymorphisms in an Asian population but not in a Caucasian population. Moreover, there were stronger associations between the rs231775 polymorphism and increased risk of bone, breast, liver, head and neck and pancreatic cancers. Additionally, rs4553808 was associated with significantly increased susceptibility to breast cancer and head and neck cancer. Conclusion: rs231775, rs4553808 and rs5742909 may be used as predictive genetic biomarkers for cancer predisposition. Combined detection of CTLA-4 SNPs could be a useful tool for prediction of cancer susceptibility in clinical practice.

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Section: Resultsmentioning

confidence: 99%

Association of Five Snps in Cytotoxic T-Lymphocyte Antigen 4 and Cancer Susceptibility: Evidence from 67 Studies

Fang

Huang

et al. 2018

Cell Physiol Biochem

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“…Previous research has found that BTLA gene polymorphisms are associated with susceptibility to autoimmune diseases and cancers, including rheumatoid arthritis (RA), breast cancer, renal cell carcinoma, and colorectal cancer [24-29]. However, few studies have focused on the association of BTLA SNPs with chronic viral infections.…”

Section: Discussionmentioning

confidence: 99%

The Influence of B and T Lymphocyte Attenuator Genetic Variants on Susceptibility to Chronic Hepatitis B Virus Infection

Tang

Fei

et al. 2018

Cell Physiol Biochem

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Background/Aims: B and T lymphocyte attenuator (BTLA) is an immune inhibitory receptor involved in the pathogenesis of chronic viral infections. Little is known about the effects of BTLA gene polymorphisms on chronic hepatitis B virus (HBV) infections. In this study, we investigated whether the polymorphisms of BTLA are associated with the progression of chronic HBV infection. Methods: A total of 382 chronic HBV carriers and 170 healthy individuals in the same region were recruited for this study. The chronic HBV carriers were divided into three groups: asymptomatic HBV carriers (ASC), moderate chronic hepatitis B group (MCHB), and severe chronic hepatitis B group (SCHB). Two BTLA functional single nucleotide polymorphisms (SNPs; rs76844316 and rs9288952) were genotyped by polymerase chain reaction and sequenced directly. Results: The results showed that the frequency of the G allele of rs76844316 was significantly lower in the SCHB group than in the other three groups. Subjects bearing at least one G allele (TG or GG genotype) at rs76844316 had decreased susceptibility to severe chronic hepatitis B compared with those bearing the TT genotype. Haplotype analysis of the two SNPs revealed that the frequency of the G-G haplotype was significantly lower in SCHB patients than in controls. Moreover, in the SCHB group, patients carrying the G allele of rs76844316 tended to have lower ALT levels than those without it. Conclusion: Our findings suggest that the genetic variants of rs76844316 in BTLA influence the susceptibility to severe chronic hepatitis B and might play a protective role against the progression of chronic hepatitis B.

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“…The study found the relation of single nucleotide polymorphisms with the predisposition to colon cancer for CTLA-4 gene like for PD-1 [34]. However, the first study of human anti-CTLA-4 monoclonal antibody (tremelimubab) in patents with chemotherapy-resistant types of colon cancer did not yield positive results [39].…”

Section: Monoclonal Antibodies In Of Colon Cancer Immunotherapymentioning

confidence: 99%

“…In particular, in literature there is contradictory information on ICP effect in colorectal cancer. On the one hand, according to the information on an increased underlying risk for reviews colon cancer in patients carrying single nucleotide polymorphisms in PD-1 gene, one might assume that the interaction between PD-1 and PD-L1 participates in colorectal carcinoma growth [34,35]. Moreover, immune histochemical study showed an increased level of PD-L1 expression in colorectal carcinoma tissues to be associated with the absence of tumor-infiltrating lymphocytes, which correlates with the poorest survival prognosis [36].…”

Section: Monoclonal Antibodies In Of Colon Cancer Immunotherapymentioning

confidence: 99%

Colorectal Cancer Immunotherapy: Current State and Prospects (Review)

Kirichenko¹,

Novikova²,

Maksimov³

et al. 2017

Sovrem Tehnol Med

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., Rostov-on-Don, 344006, Russian Federation Currently, new knowledge on immunotherapy in solid tumors is being intensively accumulated and new promising techniques are originating. The most advanced are those in the field of searching for new immune checkpoints, development of highly efficient immune adjuvants based on recombinant viruses to improve the effect of anticancer vaccines, as well as design engineering of chimeric receptors of T cells used for adoptive immunotherapy. We have presented some clinical trial results of immunotherapeutic approaches, as well as experimental studies on animal models, which offer new prospects for colon cancer treatment.

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Association between co-inhibitory molecule gene tagging single nucleotide polymorphisms and the risk of colorectal cancer in Chinese

Abstract: These data indicate potential associations between BTLA and PD-1 polymorphisms and CRC susceptibility. Additionally, the three co-inhibitory molecule gene SNPs have environmental interactions associated with CRC risk.

Cited by 43 publications

References 42 publications

Association of Five Snps in Cytotoxic T-Lymphocyte Antigen 4 and Cancer Susceptibility: Evidence from 67 Studies

Association of Five Snps in Cytotoxic T-Lymphocyte Antigen 4 and Cancer Susceptibility: Evidence from 67 Studies

The Influence of B and T Lymphocyte Attenuator Genetic Variants on Susceptibility to Chronic Hepatitis B Virus Infection

Colorectal Cancer Immunotherapy: Current State and Prospects (Review)

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