Association between coffee consumption and risk of bladder cancer in a meta-analysis of 16 prospective studies

Fujita

et al. 2020

IJMS

Bladder cancer is the most common cancer of the urinary tract. Although nonmuscle-invasive bladder cancers have a good prognosis, muscle-invasive bladder cancers promote metastases and have a poor prognosis. Comprehensive analyses using RNA sequence of clinical tumor samples in bladder cancer have been reported. These reports implicated the candidate genes and pathways that play important roles in carcinogenesis and/or progression of bladder cancer. Further investigations for the function of each mutation are warranted. There is suggestive evidence for several environmental factors as risk factors of bladder cancer. Environmental factors such as cigarette smoking, exposure to chemicals and gases, bladder inflammation due to microbial and parasitic infections, diet, and nutrition could induce several genetic mutations and alter the tumor microenvironment, such as immune cells and fibroblasts. The detailed mechanism of how these environmental factors induce carcinogenesis and/or progression of bladder cancer remains unclear. To identify the relationship between the mutations and the lifestyle could be useful for prevention and treatment of bladder cancer.

Section: Potential Effects Of Environmental Factors On Bladder Canmentioning

confidence: 99%

Mutational Landscape and Environmental Effects in Bladder Cancer

Fujita

et al. 2020

IJMS

“…Case-control study conducted by Yu et al reported the positive association between coffee consumption and bladder cancer among never smokers but not in current smokers [3]. Meta-analysis published by Dai et al reported that to date available evidence was insufficient to support an independent association between coffee consumption and bladder cancer risk [2]. Although, there was an increased risk of bladder cancer related to higher coffee consumption among studies with fewer cases (RR high vs low = 1.38, 95% CI 1.05-1.81), smoking was poorly adjusted among these studies.…”

Section: Introductionmentioning

confidence: 99%

“…In previous studies, several risk factors were identified for early diagnosis or prevention of this type of cancer. Smoking [ 1 ], coffee consumption [ 2 , 3 ], occupational exposure [ 4 ], and dietary factors [ 5 ] constitute the most important exogenous risk factors for bladder carcinogenesis [ 6 ]. Among these, smoking is the most well-known risk factor for bladder cancer [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Trajectory of smoking and early bladder cancer risk among Korean young adult men

Jee

Kim

Back³

et al. 2020

Cancer Causes Control

Objectives The aim of this study was to examine the risk of bladder cancer according to the trajectory pattern of amount of smoking among Korean young adult men. Methods Smoking status was assessed with a standardized questionnaire in the Korean Life Course Health Study (KLCHS). Trajectory analyses were performed among young adult men using seven repeated surveys of cigarette per day (CPD) every two years from 1992 to 2005. The occurrence of bladder cancer was tracked from 2006 to 2016. The Cox proportional models were used to calculate the hazard ratio (HR) (95% confidence interval) of smoking patterns on bladder cancer. Results The mean (standard deviation) age of the 161,069 participants was 34.0 (3.9) years, and 2,280,143 person-years (PY) were examined during the follow-up period of 14.2 (median 14.3) years. During this period, 263 new cases of bladder cancer occurred (11.5/100,000 PY). Among the six trajectory groups (low steady, lowering, rise and fall, high steady, rise and sharp fall, and very high steady), there was a higher risk of developing bladder cancer in the all the other groups compared to the low steady group. The highest risk group was the very high steady group, with HR 2.83 (95% CI 1.79-4.49). In addition, the risk of bladder cancer was 2.61 (95% CI 1.50-4.54) in the rise and sharp fall group. Conclusion The risk of bladder cancer did not show much difference according to trajectories, except for low steady group. Thus quitting smoking should be the priority to lower the risk of bladder cancer in smokers.

“…A cohort study and a meta-analysis found no association between coffee drinking and bladder cancer risk [ 72 ], which was confirmed in a recent meta-analysis of 16 prospective studies [ 135 ]. Likewise, meta-analyses suggest no association or a slightly reduced risk of kidney cancer in coffee drinkers [ 136 , 137 ].…”

Section: Impact Of Coffee On Cancer Risk In Humansmentioning

confidence: 82%

The Coffee–Acrylamide Apparent Paradox: An Example of Why the Health Impact of a Specific Compound in a Complex Mixture Should Not Be Evaluated in Isolation

Nehlig

Cunha

2020

Nutrients

The health implications of acrylamide in food are a matter of concern based on toxicological studies in rodents, which showed that doses of acrylamide more than 100 times higher than those estimated to result from dietary exposure in humans are carcinogenic; however, the cancer types reported in rodents are species-specific, and whether these results can be extrapolated to humans is still in question. In fact, human epidemiological studies revealed a general lack of association between dietary acrylamide exposure and the incidence of different cancer types. Even occupational exposure to acrylamide, resulting in acrylamide exposure nearly 10 times higher than dietary exposure, did not increase tumor occurrence. Furthermore, the consumption of coffee, which is a main contributor of dietary acrylamide exposure, actually decreases the overall incidence of cancer in humans and afford global health benefits, increasing both lifespan and healthspan on ageing. This paradox clearly illustrates the risk of evaluating an individual molecule independently of its complete food matrix, which may have other components that completely override the effects of the considered molecule.