Association between coffee consumption and all‐sites cancer incidence and mortality

Abstract

The preventive effect of coffee on cancer at different sites has been reported, but the effect on all‐sites cancer incidence has not been extensively investigated. We evaluated the association between frequency of coffee consumption and risk of all‐sites cancer incidence and mortality among 39 685 men and 43 124 women (age 40–79 years, at baseline), in the Three‐Prefecture Cohort Study. The association between frequency of coffee consumption and risk of all‐sites cancer incidence and mortality was assessed by a Cox proportional hazards regression model, adjusted for potential confounders. During 411 341 person‐years among men and 472 433 person‐years among women, a total of 4244 men and 2601 women developed cancer at different sites and a total of 3021 men and 1635 women died of cancer at different sites. We showed an inverse association between frequency of coffee consumption and all‐sites cancer incidence in both men and women. Comparing participants who consumed coffee with those who never drank coffee, the adjusted hazard ratios (95% confidential interval) for all‐sites cancer incidence was 0.74 (0.62–0.88) for coffee consumption of ≥5 cups/day in men (P for trend < 0.001) and 0.76 (0.58–1.02) in women (P for trend = 0.020). Coffee consumption frequency was inversely associated with mortality from all‐sites cancer. In this population, increasing coffee consumption resulted in a decreased risk of all‐sites cancer incidence and mortality.

Quantitative Proteomic Analysis Reveals Caffeine‐Perturbed Proteomic Profiles in Normal Bladder Epithelial Cells

“…Premature cleavage and polyadenylation in MAGI3, MAGI3pPA, was identified to result in an oncogenic protein in breast cancer [38] . Given that the overexpressed MAGI3 has a functional link to the suppressed oncogenic characteristics, our data support the hypothesis that caffeine might benefit to prevention of cancer development, which consistent with previous reports showing that coffee consumption inversely associated with a decreased risk of cancer including prostate cancer [39] .…”

Coffee Consumption and All-Cause, Cardiovascular, and Cancer Mortality in an Adult Mediterranean Population

“…Regarding cancer mortality, the inverse association we found is consistent with previous studies in different populations [ 35 , 37 , 38 ], although there are some studies showing no association [ 12 , 36 ]. Other studies have shown an inverse association with specific types of cancer [ 41 , 42 ]; however, two recently published meta-analyses provided evidence for an inverse association with cancer mortality [ 1 , 11 ]. Overall, the present evidence suggests that moderate coffee consumption may reduce cancer mortality, as shown in our study that the consumption of more than one cup per day was associated with a 59% decreased risk of cancer mortality.…”

Risk-Only Assessment of Genetically Engineered Crops Is Risky

“…Recently, under California's Safe Drinking Water and Toxic Enforcement Act, also known as Proposition 65, the Council for Education and Research on Toxics sued the coffee industry and won a court decision requiring coffee to be labeled with a cancer warning because it contains very low levels of acrylamide produced during roasting from the naturally occurring precursors sucrose and asparagine [86] (https://www.popsci.com/california-coffee-cancer-warning). By not considering the benefits of coffee, particularly in reducing cancer rates [87], this proposed cancer warning label could reduce coffee consumption and consequently result in increased rates of cancer (https://www.hsph.harvard.edu/nutritionsource/2018/04/02/ coffee-warning-label-conflicts-with-public-health-guidance/).…”