Association between Cognitive Frailty and Adverse Outcomes among Older Adults: A Meta-Analysis

Zhang, Xiao Ming; Wu, Xin Juan; Cao, Jianzhong; Jiao, Jing; Chen, W.

doi:10.1007/s12603-022-1833-5

Cited by 11 publications

(5 citation statements)

References 52 publications

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“…A substantial amount of research has found that association between cognitive frailty in communitydwelling older adults and various adverse outcomes [43][44][45]. Many communities have incorporated cognitive frailty into their assessments.…”

Section: Discussionmentioning

confidence: 99%

Association of preoperative cognitive frailty with postoperative complications in elderly patients under general anesthesia: a prospective cohort study

FANG,

LIANG,

CHEN

et al. 2024

Preprint

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Background Cognitive frailty is defined as the coexistence of physical frailty and mild cognitive impairment, which is associated with adverse outcomes. Due to various factors such as age-related changes in the brain and the presence of comorbidities, the elderly are more susceptible to cognitive frailty. Objective To investigate the effect of preoperative cognitive frailty on postoperative complications in elderly patients. Methods This prospective observational study was conducted among 253 patients aged 60–85 years, who underwent elective orthopedic and abdominal surgery (postoperative hospital stay ≥ 3 days ) in the Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from May 2023 to November 2023. Cognitive frailty was assessed using the MoCA for the cognitive status and the Fried criteria for five frailty scales. The participants were split into the following groups: group A, neither frail nor cognitive impairment; group B, only frailty ; group C, only cognitive impairment; group D, cognitive frailty. Primary outcome was the impact on postoperative complications. Secondary outcomes included mobility disability, prolonged hospital stay, re-operation and 90-day readmission. Results The median age ( interquartile range ) of participants was 69 (65–73) years, of which 40.3% were male. The prevalence of cognitive frailty was 17.8%. The incidence of postoperative complications was 18.2% in group A, 50.0% in group B, 37.4% in group C, and 75.6% in group D. The difference was significant (P < 0.001). In the multivariate analysis, cognitive frailty [odds ratio (OR), 16.84; 95% confidence interval (CI), 4.54–62.37], only frailty (OR, 7.86; 95%CI, 2.12-29. 12), only cognitive impairment (OR, 4.22; 95%CI, 1.62–11.02). Conclusions Cognitive frailty was associated with higher risks of postoperative complications in elderly patients undergoing general anesthesia. It indicates that clinicians should pay much attention to these elderly with cognitive frailty.

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Section: Discussionmentioning

confidence: 99%

Association of preoperative cognitive frailty with postoperative complications in elderly patients under general anesthesia: a prospective cohort study

FANG,

LIANG,

CHEN

et al. 2024

Preprint

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“…The association between disability and cognitive frailty has also been demonstrated in longitudinal studies [ 16 , 55 – 57 ]. In a meta-analysis study, Zhang et al [ 10 ] determined that older adults with cognitive frailty were three times more likely (OR 3.16) to have disability compared to those without cognitive frailty. Therefore, disability can be considered as both a risk factor and an adverse consequence of cognitive frailty.…”

Section: Discussionmentioning

confidence: 99%

“…GDS-15 consists of 15 yes/no questions with a score ranging from 0 to 15 and higher scores indicating higher probability of depression. We further categorized depression severity into four subgroups based on GDS-15 scores; normal (0-4), mild (5-8), moderate (9)(10)(11) and severe (12)(13)(14)(15). Subsequently, for the purposes of logistic regression analysis, individuals with mild or worse depression severity were classified as having depression.…”

Section: Methodsmentioning

confidence: 99%

“…A multitude of studies have demonstrated the detrimental effect of cognitive frailty on adverse health outcomes. Individuals with cognitive frailty are at increased risk of disability, hospitalisation, low quality of life, dementia and mortality [9][10][11][12][13][14][15]. Increased risk of mortality is particularly noteworthy because of its direct and indirect pathways.…”

Section: Introductionmentioning

confidence: 99%

“…Increased risk of mortality is particularly noteworthy because of its direct and indirect pathways. Cognitive frailty increases the risk of all-cause mortality not only directly [12,14,15], but also indirectly through diminished functional domains and disability [10,11], dementia [13,14] and increased risk of falls and its consequent injuries [16]. Additionally, those with cognitive frailty are more likely to be dependent on long term care, which in turn, can potentially increase the burden of this condition [17].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of cognitive frailty and its associated factors in a population of Iranian older adults

Ghanbarnia,

Hosseini,

Ahangar

et al. 2024

Aging Clin Exp Res

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Background In recent years cognitive frailty has emerged as an important predictor of adverse health outcomes in older adults. Herein, we aimed to investigate the prevalence and associated factors of cognitive frailty in a population of community-dwelling older adults in Iran. Method This cross-sectional study was conducted as part of the second cycle of the Amirkola Health and Aging Project (AHAP). Physical frailty and cognitive impairment were evaluated using the FRAIL questionnaire and the mini-mental state examination (MMSE) respectively. Cognitive frailty was defined as co-existence of frailty and cognitive impairment without presence of dementia. Depression and disability were assessed using the Persian version of geriatric depression scale (GDS) and instrumental activities of daily living (IADL) questionnaire. Results Overall 1775 individuals (47.1% female) with mean age of 69.7 ± 7.3 years were included in the final analysis. The prevalence of cognitive frailty was 12.0%. The prevalence of cognitive frailty among males and females was 4.3% and 20.7%, respectively. After adjusting for all possible confounders through binary logistic regression analysis, factors such as older age (OR 1.06, CI 1.03–1.09), female gender (OR 2.25, CI 1.42–3.57), illiteracy (OR 3.84, CI 2.03–8.29), more comorbidities (OR 1.21, CI 1.12–1.31), depression (OR 2.01, CI 1.40–2.86), and greater IADL disability (OR 1.68, CI 1.44–3.96), were independently and significantly associated with cognitive frailty. Conclusion In this population of Iranian older adults, prevalence of cognitive frailty was consistent with its estimated mean global prevalence. Age, gender, illiteracy, comorbidities, depression and IADL disability were associated with cognitive frailty. Further research is required to develop screening tools and prevention strategies.

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Construction and validation of a nomogram for predicting fear of falling related activity restrictions in community-dwelling older adults

Zhang,

Xue,

Zhou

et al. 2024

Geriatric Nursing

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Association between Cognitive Frailty and Adverse Outcomes among Older Adults: A Meta-Analysis

Cited by 11 publications

References 52 publications

Association of preoperative cognitive frailty with postoperative complications in elderly patients under general anesthesia: a prospective cohort study

Association of preoperative cognitive frailty with postoperative complications in elderly patients under general anesthesia: a prospective cohort study

Prevalence of cognitive frailty and its associated factors in a population of Iranian older adults

Construction and validation of a nomogram for predicting fear of falling related activity restrictions in community-dwelling older adults

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