Association between cognitive function and olfactory identification ability in community-dwelling older individuals

Abstract

[Purpose] We investigated whether olfactory identification ability may be useful for early detection of cognitive decline. [Participants and Methods] The study included 55 community-dwelling older individuals without a history of mild cognitive impairment or dementia, who were capable of living independently. Cognitive function was evaluated using the Japanese versions of the Mini-Mental State Examination and the Montreal Cognitive Assessment tools. The olfactory identification ability was evaluated using the Odor Stick Identification Test for the Japanese. We also investigated the association between olfactory identification ability and cognitive function. [Results] Based on the Japanese version of the Mini-Mental State Examination, all participants were categorized into the noncognitive decline group, and based on the Japanese version of the Montreal Cognitive Assessment tool, 21 participants were categorized into the cognitive decline group. With regard to olfactory discrimination ability, we observed a significant difference between participants with and without cognitive decline based on the Japanese version of the Montreal Cognitive Assessment scores. Furthermore, we observed a significant positive correlation between the Japanese version of the the Montreal Cognitive Assessment scores and the Odor Stick Identification Test for the Japanese scores, although no significant correlation was observed between the Japanese version of the Mini-Mental State Examination and the Odor Stick Identification Test for the Japanese scores. [Conclusion] Olfactory identification ability may be useful to detect early-stage cognitive decline in community-dwelling older individuals.

Parvalbumin interneuron ErbB4 controls ongoing network oscillations and olfactory behaviors in mice

“…The copyright holder for this preprint this version posted July 25, 2024. ; https://doi.org/10.1101/2024.07.25.604407 doi: bioRxiv preprint significant predictive valence for future cognitive decline in healthy aging individuals (Carnemolla et al, 2020;Sohrabi et al, 2012;Uchida et al, 2020;Yoshitake et al, 2022). ErbB4 has been independently identified as a susceptibility gene for Alzheimer's disease and schizophrenia (Mei and Nave, 2014;Swaminathan et al, 2012).…”

“…In recent decades, impaired odor discrimination has been found in the earliest stages of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease (Dan et al, 2021). Olfactory discrimination deficits develop prior to neuropsychological characteristics in patients with Alzheimer's disease and have 21 significant predictive valence for future cognitive decline in healthy aging individuals (Carnemolla et al, 2020;Sohrabi et al, 2012;Uchida et al, 2020;Yoshitake et al, 2022). ErbB4 has been independently identified as a susceptibility gene for Alzheimer's disease and schizophrenia (Mei and Nave, 2014;Swaminathan et al, 2012).…”

“…Dysfunction in olfactory discrimination has been observed in the earliest stages of several neurodegenerative disorders and psychiatric diseases (Carnemolla et al, 2020;Walker et al, 2021). Similarly, olfactory discrimination ability has significant predictive valence for future cognitive decline in healthy aging individuals (Sohrabi et al, 2012;Uchida et al, 2020;Yoshitake et al, 2022).…”