Association between cognitive impairment promoted by high-fat diet and increase in PTEN phosphorylation

Chen, Xiaoyi; Ma, Liang; Zhao, Jingyu; Pan, Xiaoyu; Chen, Shuchun

doi:10.1016/j.bbr.2023.114421

Behavioural Brain Research

2023

DOI: 10.1016/j.bbr.2023.114421

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Association between cognitive impairment promoted by high-fat diet and increase in PTEN phosphorylation

Xiaoyi Chen

Liang Ma

Jingyu Zhao

et al.

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2024

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Cited by 2 publications

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Exploring the impact of lipid stress on sperm cytoskeleton: insights and prospects

Saez Lancellotti,

Avena,

Funes

et al. 2024

Nat Rev Urol

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Exploring the impact of lipid stress on sperm cytoskeleton: insights and prospects

Saez Lancellotti,

Avena,

Funes

et al. 2024

Nat Rev Urol

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PCSK9 induces endothelial cell autophagy by regulating the PI3K/ATK pathway in atherosclerotic coronary heart disease

Li,

Guo,

Wang

et al. 2024

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OBJECTIVE: Atherosclerosis is a chronic inflammatory disease of the arteries, and its pathogenesis is related to endothelial dysfunction. It has been found that the protein convertase subtilin/kexin9 type (PCSK9) plays an important role in AS, but its specific mechanism is still unclear. METHODS: In this study, we first cultured human umbilical vein endothelial cells (HUVECs) with 50 or 100μg/ml oxidized low-density lipoprotein (ox-LDL) for 24 hours to establish a coronary atherosclerosis cell model. RESULTS: The results showed that ox-LDL induced HUVEC injury and autophagy and upregulated PCSK9 protein expression in HUVECs in a concentration-dependent manner. Silencing PCSK9 expression with siRNA inhibited ox-LDL-induced HUVEC endothelial dysfunction, inhibited the release of inflammatory factors, promoted HUVEC proliferation and inhibited apoptosis. In addition, ox-LDL increased the expression of LC3B-I and LC3B-II and decreased the expression of p62. However, these processes are reversed by sh-PCSK9. In addition, sh-PCSK9 can inhibit PI3K, AKT and mTOR phosphorylation and promote autophagy. CONCLUSION: Taken together, our research shows that silencing PCSK9 inhibits the PI3K/ATK/mTOR pathway to activate ox-LDL-induced autophagy in vascular endothelial cells, alleviating endothelial cell injury and inflammation.

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Association between cognitive impairment promoted by high-fat diet and increase in PTEN phosphorylation

Cited by 2 publications

References 30 publications

Exploring the impact of lipid stress on sperm cytoskeleton: insights and prospects

Exploring the impact of lipid stress on sperm cytoskeleton: insights and prospects

PCSK9 induces endothelial cell autophagy by regulating the PI3K/ATK pathway in atherosclerotic coronary heart disease

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