Association between Combined Structure Function Index and Glaucoma Severity

Ogawa, Shumpei; Tanabe, Yukitoshi; Itoh, Yoshinori; Noro, Takahiko; Gunji, Hisato; Nakano, Tadashi

doi:10.1155/2019/9414675

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…Previous studies showed the agreement between functional and structural examinations tends to decrease as glaucoma progresses. For example, consistency between combined structure function index (CSFI) and standard automated perimetry (SAP) indices in middle-stage glaucoma was reported to be low [32]. Further studies are warranted to examine the consistency between OCT and visual field parameters during progression in glaucoma patients with high myopia.…”

Section: Discussionmentioning

confidence: 99%

Consistency between optical coherence tomography and humphrey visual field for evaluating glaucomatous defects in high myopic eyes

Wen

Zhang

et al. 2020

BMC Ophthalmol

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Background The study is to investigate the influence of high myopia on the consistency between optical coherence tomography (OCT) and visual field in primary open-angle glaucoma (POAG). Methods We enrolled 37 patients with POAG with high myopia (POAG-HM group), 27 patients with POAG without high myopia (POAG group), and 29 controls with high myopia (HM group). All subjects underwent Humphrey perimetry (30–2 and 10–2 algorithms). The peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thicknesses were measured using Cirrus HD-OCT. Spearman’s rank correlation analysis was used to determine correlations between OCT and perimetric parameters. Agreement was analyzed by cross-classification and weighted κ statistics. Results In POAG group, the cross-classification analysis showed strong agreement between the inferior temporal GCIPL thickness and the mean sensitivity (MS) of 10–2 algorithms (κ = 0.5447, P = 0.0048), and good agreement between the superior and inferior RNFL thicknesses and 30–2 MS (κ = 0.4407 and 0.4815; P < 0.05). In the POAG-HM group, only the inferior temporal GCIPL thickness showed good agreement with 10–2 MS (κ = 0.3155, P = 0.0289) and none of the RNFL sectors were in good agreement with the corresponding MS. Conclusions In POAG patients with high myopia, changes in macular measurements were in accordance with visual field defects, and RNFL thickness did not consistently decline with visual field defects due to the effects of high myopia. This study suggests that during diagnosis and follow-up of glaucoma with high myopia, more attention need to be focused on structure and functional defects in macular areas.

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Section: Discussionmentioning

confidence: 99%

Consistency between optical coherence tomography and humphrey visual field for evaluating glaucomatous defects in high myopic eyes

Wen

Zhang

et al. 2020

BMC Ophthalmol

View full text Add to dashboard Cite

show abstract

“…Previous studies showed the agreement between functional and structural examinations tends to decrease as glaucoma progresses. For example, consistency between combined structure function index (CSFI) and standard automated perimetry (SAP) indices in middle-stage glaucoma was reported to be low 32 . Further studies are warranted to examine the consistency between OCT and visual eld parameters during progression in glaucoma patients with high myopia.…”

Section: Discussionmentioning

confidence: 99%

Consistency between Optical Coherence Tomography and Humphrey Visual Field for Evaluating Glaucomatous Defects in High Myopic Eyes

Wen¹,

Zhang

et al. 2020

Preprint

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Background. The study is to investigate the influence of high myopia on the consistency between optical coherence tomography (OCT) and visual field in primary open-angle glaucoma (POAG).Methods. We enrolled 37 patients with POAG with high myopia (POAG-HM group), 27 patients with POAG without high myopia (POAG group), and 29 controls with high myopia (HM group). All subjects underwent Humphrey perimetry (30-2 and 10-2 algorithms). The peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thicknesses were measured using Cirrus HD-OCT. Spearman’s rank correlation analysis was used to determine correlations between OCT and perimetric parameters. Agreement was analyzed by cross-classification and weighted κ statistics.Results. In POAG group, the cross-classification analysis showed strong agreement between the inferior temporal GCIPL thickness and the mean sensitivity (MS) of 10-2 algorithms (κ = 0.5447, P = 0.0048), and good agreement between the superior and inferior RNFL thicknesses and 30-2 MS (κ = 0.4407 and 0.4815; P < 0.05). In the POAG-HM group, only the inferior temporal GCIPL thickness showed good agreement with 10-2 MS (κ = 0.3155, P = 0.0289) and none of the RNFL sectors were in good agreement with the corresponding MS.Conclusions. In POAG patients with high myopia, changes in macular measurements were in accordance with visual field defects, and RNFL thickness did not consistently decline with visual field defects due to the effects of high myopia. This study suggests that during diagnosis and follow-up of glaucoma with high myopia, more attention need to be focused on structure and functional defects in macular areas.

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Does Retinal Ganglion Cell Loss Precede Visual Field Loss in Glaucoma?

Hood

2019

Journal of Glaucoma

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It is often said that substantial retinal ganglion cells are lost before glaucomatous damage is detected by standard automated perimetry. There are 4 key articles referenced to support this belief. To test the hypothesis that the 4 key articles are incorrectly cited, the publications in the first 6 months of 2019 that reference 1 or more of these 4 articles were examined. In particular, the degree to which the quotes from these 2019 publications accurately reflected the evidence in the 4 key articles was assessed. These quotes are inadequately supported by the data, and in some cases even by the conclusions found in the abstracts of the key articles. This is despite several review articles that have questioned the evidence in these key articles. Further, a case can be made that the evidence in the key articles better supports the opposite conclusion. That is, the data suggest that sensitivity loss can be seen on standard automated perimetry before retinal ganglion cells are missing.

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Association between Combined Structure Function Index and Glaucoma Severity

Cited by 3 publications

References 33 publications

Consistency between optical coherence tomography and humphrey visual field for evaluating glaucomatous defects in high myopic eyes

Consistency between optical coherence tomography and humphrey visual field for evaluating glaucomatous defects in high myopic eyes

Consistency between Optical Coherence Tomography and Humphrey Visual Field for Evaluating Glaucomatous Defects in High Myopic Eyes

Does Retinal Ganglion Cell Loss Precede Visual Field Loss in Glaucoma?

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